Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase
Guengerich, F Peter, Martin, Martha V, Sohl, Christal D, Cheng, Qian
Published in Nature protocols (01.09.2009)
Published in Nature protocols (01.09.2009)
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Journal Article
Kinetic Analysis of the Three-step Steroid Aromatase Reaction of Human Cytochrome P450 19A1
Sohl, Christal D., Guengerich, F. Peter
Published in The Journal of biological chemistry (04.06.2010)
Published in The Journal of biological chemistry (04.06.2010)
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Journal Article
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms
Mealka, Matthew, Sierra, Nicole A, Avellaneda Matteo, Diego, Albekioni, Elene, Khoury, Rachel, Mai, Timothy, Conley, Brittany M, Coleman, Nalani J, Sabo, Kaitlyn A, Komives, Elizabeth A, Bobkov, Andrey A, Cooksy, Andrew L, Silletti, Steve, Schiffer, Jamie M, Huxford, Tom, Sohl, Christal D
Published in Nature communications (06.05.2024)
Published in Nature communications (06.05.2024)
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Journal Article
Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles’ Heel of Targeted Therapy
Sohl, Christal D, Ryan, Molly R, Luo, BeiBei, Frey, Kathleen M, Anderson, Karen S
Published in ACS chemical biology (15.05.2015)
Published in ACS chemical biology (15.05.2015)
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Journal Article
Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymeraseγ
Sohl, Christal D., Szymanski, Michal R., Mislak, Andrea C., Shumate, Christie K., Amiralaei, Sheida, Schinazi, Raymond F., Anderson, Karen S., Yin, Y. Whitney
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2015)
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Journal Article
Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms
Guengerich, F. Peter, Sohl, Christal D., Chowdhury, Goutam
Published in Archives of biochemistry and biophysics (01.03.2011)
Published in Archives of biochemistry and biophysics (01.03.2011)
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Journal Article
Pools and Pols: Mechanism of a mutator phenotype
Sohl, Christal D., Ray, Sreerupa, Sweasy, Joann B.
Published in Proceedings of the National Academy of Sciences - PNAS (12.05.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (12.05.2015)
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Journal Article
Oxidation of Dihydrotestosterone by Human Cytochromes P450 19A1 and 3A4
Cheng, Qian, Sohl, Christal D., Yoshimoto, Francis K., Guengerich, F.Peter
Published in The Journal of biological chemistry (24.08.2012)
Published in The Journal of biological chemistry (24.08.2012)
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Journal Article
Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics
Weeks, Joi, Strom, Alexandra I, Widjaja, Vinnie, Alexander, Sati, Pucher, Dahra K, Sohl, Christal D
Published in Biomolecules (Basel, Switzerland) (16.05.2021)
Published in Biomolecules (Basel, Switzerland) (16.05.2021)
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Journal Article
Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1
Wu, Zhong-Liu, Sohl, Christal D, Shimada, Tsutomu, Guengerich, F Peter
Published in Molecular pharmacology (01.06.2006)
Published in Molecular pharmacology (01.06.2006)
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Journal Article
Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells
Bernatchez, Jean A, Coste, Michael, Beck, Sungjun, Wells, Grace A, Luna, Lucas A, Clark, Alex E, Zhu, Zhe, Hecht, David, Rich, Jeremy N, Sohl, Christal D, Purse, Byron W, Siqueira-Neto, Jair L
Published in Viruses (20.04.2019)
Published in Viruses (20.04.2019)
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Journal Article
Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) using pre-steady-state kinetics
Muftuoglu, Yagmur, Sohl, Christal D., Mislak, Andrea C., Mitsuya, Hiroaki, Sarafianos, Stefan G., Anderson, Karen S.
Published in Antiviral research (01.06.2014)
Published in Antiviral research (01.06.2014)
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Journal Article
Mechanism of Interaction of Human Mitochondrial DNA Polymerase γ with the Novel Nucleoside Reverse Transcriptase Inhibitor 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine Indicates a Low Potential for Host Toxicity
SOHL, Christal D, SINGH, Kamlendra, KASIVISWANATHAN, Rajesh, COPELAND, William C, MITSUYA, Hiroaki, SARAFIANOS, Stefan G, ANDERSON, Karen S
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
Published in Antimicrobial Agents and Chemotherapy (01.03.2012)
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Journal Article
The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT
Ryan, Molly R, Sohl, Christal D, Luo, BeiBei, Anderson, Karen S
Published in Molecular cancer research (01.02.2019)
Published in Molecular cancer research (01.02.2019)
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Journal Article
Undergraduate research data crucial to equity
Thoman, Dustin B, Smith, Jessi L, Hernandez, Ivan A, Sohl, Christal D, Villodas, Miguel T
Published in Science (American Association for the Advancement of Science) (17.05.2024)
Published in Science (American Association for the Advancement of Science) (17.05.2024)
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Journal Article
Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen–Deuterium Exchange Mass Spectrometry
Sabo, Kaitlyn A., Albekioni, Elene, Caliger, Danielle, Coleman, Nalani J., Thornberg, Ella, Avellaneda Matteo, Diego, Komives, Elizabeth A., Silletti, Steve, Sohl, Christal D.
Published in Biochemistry (Easton) (21.03.2023)
Published in Biochemistry (Easton) (21.03.2023)
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Journal Article