Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma
Napolitano, Valeria, Softley, Charlotte A, Blat, Artur, Kalel, Vishal C, Schorpp, Kenji, Siebenmorgen, Till, Hadian, Kamyar, Erdmann, Ralf, Sattler, Michael, Popowicz, Grzegorz M, Dubin, Grzegorz
Published in Scientific reports (29.08.2022)
Published in Scientific reports (29.08.2022)
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Paramagnetic NMR in drug discovery
Softley, Charlotte A., Bostock, Mark J., Popowicz, Grzegorz M., Sattler, Michael
Published in Journal of biomolecular NMR (01.07.2020)
Published in Journal of biomolecular NMR (01.07.2020)
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Deep learning model predicts water interaction sites on the surface of proteins using limited-resolution data
Zaucha, Jan, Softley, Charlotte A, Sattler, Michael, Frishman, Dmitrij, Popowicz, Grzegorz M
Published in Chemical communications (Cambridge, England) (21.12.2020)
Published in Chemical communications (Cambridge, England) (21.12.2020)
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Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents
Fino, Roberto, Lenhart, Dominik, Kalel, Vishal C, Softley, Charlotte A, Napolitano, Valeria, Byrne, Ryan, Schliebs, Wolfgang, Dawidowski, Maciej, Erdmann, Ralf, Sattler, Michael, Schneider, Gisbert, Plettenburg, Oliver, Popowicz, Grzegorz M
Published in Journal of chemical information and modeling (25.10.2021)
Published in Journal of chemical information and modeling (25.10.2021)
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Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase
Softley, Charlotte A, Zak, Krzysztof M, Bostock, Mark J, Fino, Roberto, Zhou, Richard Xu, Kolonko, Marta, Mejdi-Nitiu, Ramona, Meyer, Hannelore, Sattler, Michael, Popowicz, Grzegorz M
Published in Antimicrobial agents and chemotherapy (21.05.2020)
Published in Antimicrobial agents and chemotherapy (21.05.2020)
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Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma
Napolitano, Valeria, Mróz, Piotr, Marciniak, Monika, Kalel, Vishal C., Softley, Charlotte A., Janna Olmos, Julian D., Tippler, Bettina G., Schorpp, Kenji, Rioton, Sarah, Fröhlich, Tony, Plettenburg, Oliver, Hadian, Kamyar, Erdmann, Ralf, Sattler, Michael, Popowicz, Grzegorz M., Dawidowski, Maciej, Dubin, Grzegorz
Published in European journal of medicinal chemistry (05.12.2022)
Published in European journal of medicinal chemistry (05.12.2022)
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19F‑NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA–Guanine Transglycosylase
Nguyen, Andreas, Gemmecker, Gerd, Softley, Charlotte A., Movsisyan, Levon D., Pfaffeneder, Toni, Heine, Andreas, Reuter, Klaus, Diederich, François, Sattler, Michael, Klebe, Gerhard
Published in ACS chemical biology (15.07.2022)
Published in ACS chemical biology (15.07.2022)
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Journal Article
19 F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA–Guanine Transglycosylase
Nguyen, Andreas, Gemmecker, Gerd, Softley, Charlotte A., Movsisyan, Levon D., Pfaffeneder, Toni, Heine, Andreas, Reuter, Klaus, Diederich, François, Sattler, Michael, Klebe, Gerhard
Published in ACS chemical biology (15.07.2022)
Published in ACS chemical biology (15.07.2022)
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