Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump
Rodrigues, A David, Lai, Yurong, Cvijic, Mary Ellen, Elkin, Lisa L, Zvyaga, Tatyana, Soars, Matthew G
Published in Drug metabolism and disposition (01.04.2014)
Published in Drug metabolism and disposition (01.04.2014)
Get full text
Journal Article
Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor
Mosure, Kathleen W., Knipe, Jay O., Browning, Marc, Arora, Vinod, Shu, Yue-Zhong, Phillip, Thomas, Mcphee, Fiona, Scola, Paul, Balakrishnan, Anand, Soars, Matthew G., Santone, Kenneth, Sinz, Michael
Published in Journal of pharmaceutical sciences (01.09.2015)
Published in Journal of pharmaceutical sciences (01.09.2015)
Get full text
Journal Article
Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
SOARS, Matthew G, GRIME, Ken, SPROSTON, Joanne L, WEBBORN, Peter J. H, RILEY, Robert J
Published in Drug metabolism and disposition (01.06.2007)
Published in Drug metabolism and disposition (01.06.2007)
Get full text
Journal Article
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
Salphati, Laurent, Chu, Xiaoyan, Chen, Liangfu, Prasad, Bhagwat, Dallas, Shannon, Evers, Raymond, Mamaril-Fishman, Donna, Geier, Ethan G, Kehler, Jonathan, Kunta, Jeevan, Mezler, Mario, Laplanche, Loic, Pang, Jodie, Rode, Anja, Soars, Matthew G, Unadkat, Jashvant D, van Waterschoot, Robert A B, Yabut, Jocelyn, Schinkel, Alfred H, Scheer, Nico
Published in Drug metabolism and disposition (01.08.2014)
Published in Drug metabolism and disposition (01.08.2014)
Get full text
Journal Article
The pivotal role of hepatocytes in drug discovery
Soars, Matthew G., McGinnity, Dermot F., Grime, Ken, Riley, Robert J.
Published in Chemico-biological interactions (20.05.2007)
Published in Chemico-biological interactions (20.05.2007)
Get full text
Journal Article
THE EFFECT OF INCUBATION CONDITIONS ON THE ENZYME KINETICS OF UDP-GLUCURONOSYLTRANSFERASES
SOARS, Matthew G, RING, Barbara J, WRIGHTON, Steven A
Published in Drug metabolism and disposition (01.06.2003)
Published in Drug metabolism and disposition (01.06.2003)
Get full text
Journal Article
Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis
Nara, Susheel J., Jogi, Srinivas, Cheruku, Srinivas, Kandhasamy, Sarkunam, Jaipuri, Firoz, Kathi, Pavan Kalyan, Reddy, Subba, Sarodaya, Sanket, Cook, Erica M., Wang, Tao, Sitkoff, Doree, Rossi, Karen A., Ruzanov, Max, Kiefer, Susan E., Khan, Javed A., Gao, Mian, Reddy, Satyanarayana, Sivaprasad LVJ, Sankara, Sane, Ramola, Mosure, Kathy, Zhuo, Xiaoliang, Cao, Gary G., Ziegler, Milinda, Azzara, Anthony, Krupinski, John, Soars, Matthew G., Ellsworth, Bruce A., Wacker, Dean A.
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
Get full text
Journal Article
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases
Cheng, Peter T. W, Zhang, Hao, Shi, Jun, Tao, Shiwei, Li, Jun, Kennedy, Lawrence J, Walker, Steven J, Shi, Yan, Wang, Ying, Dhanusu, Suresh, Reddigunta, Ramesh, Kumaravel, Selvakumar, Jusuf, Sutjano, Smith, Daniel, Krishnananthan, Subramaniam, Li, Jianqing, Wang, Tao, Heiry, Rebekah, Sum, Chi Shing, Kalinowski, Stephen S, Hung, Chen-Pin, Chu, Ching-Hsuen, Azzara, Anthony V, Ziegler, Milinda, Burns, Lisa, Zinker, Bradley A, Boehm, Stephanie, Taylor, Joseph, Sapuppo, Julia, Mosure, Kathy, Everlof, Gerry, Guarino, Victor, Zhang, Lisa, Yang, Yanou, Ruan, Qian, Xu, Carrie, Apedo, Atsu, Traeger, Sarah C, Cvijic, Mary Ellen, Lentz, Kimberley A, Tirucherai, Giridhar, Sivaraman, Lakshmi, Robl, Jeffrey, Ellsworth, Bruce A, Rosen, Glenn, Gordon, David A, Soars, Matthew G, Gill, Michael, Murphy, Brian J
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
Get full text
Journal Article
The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement
Donnelly, David J., Kim, Joonyoung, Tran, Tritin, Scola, Paul M., Tenney, Daniel, Pena, Adrienne, Petrone, Thomas, Zhang, Yunhui, Boy, Kenneth M., Poss, Michael A., Cole, Erin L., Soars, Matthew G., Johnson, Benjamin M., Cohen, Daniel, Batalla, Daniel, Chow, Patrick L., Shorts, Andrea Olga, Du, Shuyan, Meanwell, Nicholas A., Bonacorsi, Samuel J.
Published in European journal of nuclear medicine and molecular imaging (01.03.2024)
Published in European journal of nuclear medicine and molecular imaging (01.03.2024)
Get full text
Journal Article
A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology
Soars, Matthew G., Gelboin, Harry V., Krausz, Kristopher W., Riley, Robert J.
Published in British journal of clinical pharmacology (01.02.2003)
Published in British journal of clinical pharmacology (01.02.2003)
Get full text
Journal Article
Late Intervention with a Myeloperoxidase Inhibitor Stops Progression of Experimental Chronic Obstructive Pulmonary Disease
CHURG, Andrew, MARSHALL, Caroline V, WRIGHT, Joanne L, SIN, Don D, BOLTON, Sarah, ZHOU, Steven, THAIN, Katherine, CADOGAN, Elaine B, MALTBY, Justine, SOARS, Matthew G, MALLINDER, Philip R
Published in American journal of respiratory and critical care medicine (2012)
Published in American journal of respiratory and critical care medicine (2012)
Get full text
Journal Article
Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer
Kim, Joonyoung, Donnelly, David J., Tran, Tritin, Pena, Adrienne, Shorts, Andrea Olga, Petrone, Thomas V., Zhang, Yunhui, Boy, Kenneth M., Scola, Paul M., Tenney, Daniel J., Poss, Michael A., Soars, Matthew G., Bonacorsi, Samuel J., Cole, Erin L., Grootendorst, Diederik J., Chow, Patrick L., Meanwell, Nicholas A., Du, Shuyan
Published in Molecular imaging and biology (01.04.2024)
Published in Molecular imaging and biology (01.04.2024)
Get full text
Journal Article
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain
Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V, Senapati, Arun, Bristow, Linda J, Meanwell, Nicholas A, Thompson, Lorin A, Dzierba, Carolyn
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
Get full text
Journal Article
Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis
Carpenter, Joseph, Wu, Gang, Wang, Ying, Cook, Erica M, Wang, Tao, Sitkoff, Doree, Rossi, Karen A, Mosure, Kathy, Zhuo, Xiaoliang, Cao, Gary G, Ziegler, Milinda, Azzara, Anthony V, Krupinski, Jack, Soars, Matthew G, Ellsworth, Bruce Alan, Wacker, Dean A
Published in ACS medicinal chemistry letters (09.09.2021)
Published in ACS medicinal chemistry letters (09.09.2021)
Get full text
Journal Article
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain
Wu, Yong-Jin, Guernon, Jason, Shi, Jianliang, Ditta, Jonathan, Robbins, Kevin J, Rajamani, Ramkumar, Easton, Amy, Newton, Amy, Bourin, Clotilde, Mosure, Kathleen, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Bristow, Linda J, Meanwell, Nicholas A, Olson, Richard, Thompson, Lorin A, Dzierba, Carolyn
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
Get full text
Journal Article
Development of a high-throughput mass spectrometry based analytical method to support an in vitro OATP1B1 inhibition screening assay
Wagner, Andrew D., Elkin, Lisa, Mosure, Kathy, Gallagher, Lizbeth, Stavola, Lindsey K., Soars, Matthew G., Shou, Wilson
Published in Rapid communications in mass spectrometry (15.08.2016)
Published in Rapid communications in mass spectrometry (15.08.2016)
Get full text
Journal Article