Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage
Bollen, Yannik, Hageman, Joris H, van Leenen, Petra, Derks, Lucca L M, Ponsioen, Bas, Buissant des Amorie, Julian R, Verlaan-Klink, Ingrid, van den Bos, Myrna, Terstappen, Leon W M M, van Boxtel, Ruben, Snippert, Hugo J G
Published in PLoS biology (28.01.2022)
Published in PLoS biology (28.01.2022)
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High-resolution 3D imaging of fixed and cleared organoids
Dekkers, Johanna F., Alieva, Maria, Wellens, Lianne M., Ariese, Hendrikus C. R., Jamieson, Paul R., Vonk, Annelotte M., Amatngalim, Gimano D., Hu, Huili, Oost, Koen C., Snippert, Hugo J. G., Beekman, Jeffrey M., Wehrens, Ellen J., Visvader, Jane E., Clevers, Hans, Rios, Anne C.
Published in Nature protocols (01.06.2019)
Published in Nature protocols (01.06.2019)
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Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
Bolhaqueiro, Ana C. F., Ponsioen, Bas, Bakker, Bjorn, Klaasen, Sjoerd J., Kucukkose, Emre, van Jaarsveld, Richard H., Vivié, Judith, Verlaan-Klink, Ingrid, Hami, Nizar, Spierings, Diana C. J., Sasaki, Nobuo, Dutta, Devanjali, Boj, Sylvia F., Vries, Robert G. J., Lansdorp, Peter M., van de Wetering, Marc, van Oudenaarden, Alexander, Clevers, Hans, Kranenburg, Onno, Foijer, Floris, Snippert, Hugo J. G., Kops, Geert J. P. L.
Published in Nature genetics (01.05.2019)
Published in Nature genetics (01.05.2019)
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Chromosomal copy number heterogeneity predicts survival rates across cancers
van Dijk, Erik, van den Bosch, Tom, Lenos, Kristiaan J., El Makrini, Khalid, Nijman, Lisanne E., van Essen, Hendrik F. B., Lansu, Nico, Boekhout, Michiel, Hageman, Joris H., Fitzgerald, Rebecca C., Punt, Cornelis J. A., Tuynman, Jurriaan B., Snippert, Hugo J. G., Kops, Geert J. P. L., Medema, Jan Paul, Ylstra, Bauke, Vermeulen, Louis, Miedema, Daniël M.
Published in Nature communications (27.05.2021)
Published in Nature communications (27.05.2021)
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Intestinal Regeneration: Regulation by the Microenvironment
Hageman, Joris H., Heinz, Maria C., Kretzschmar, Kai, van der Vaart, Jelte, Clevers, Hans, Snippert, Hugo J.G.
Published in Developmental cell (24.08.2020)
Published in Developmental cell (24.08.2020)
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Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Ponsioen, Bas, Post, Jasmin B., Buissant des Amorie, Julian R., Laskaris, Dimitrios, van Ineveld, Ravian L., Kersten, Simone, Bertotti, Andrea, Sassi, Francesco, Sipieter, François, Cappe, Benjamin, Mertens, Sander, Verlaan-Klink, Ingrid, Boj, Sylvia F., Vries, Rob G. J., Rehmann, Holger, Vandenabeele, Peter, Riquet, Franck B., Trusolino, Livio, Bos, Johannes L., Snippert, Hugo J. G.
Published in Nature cell biology (01.04.2021)
Published in Nature cell biology (01.04.2021)
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Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage
Heinz, Maria C, Peters, Niek A, Oost, Koen C, Lindeboom, Rik G H, van Voorthuijsen, Lisa, Fumagalli, Arianna, van der Net, Mirjam C, de Medeiros, Gustavo, Hageman, Joris H, Verlaan-Klink, Ingrid, Borel Rinkes, Inne H M, Liberali, Prisca, Gloerich, Martijn, van Rheenen, Jacco, Vermeulen, Michiel, Kranenburg, Onno, Snippert, Hugo J G
Published in Cancer research (Chicago, Ill.) (16.05.2022)
Published in Cancer research (Chicago, Ill.) (16.05.2022)
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Snake Venom Gland Organoids
Post, Yorick, Puschhof, Jens, Beumer, Joep, Kerkkamp, Harald M., de Bakker, Merijn A.G., Slagboom, Julien, de Barbanson, Buys, Wevers, Nienke R., Spijkers, Xandor M., Olivier, Thomas, Kazandjian, Taline D., Ainsworth, Stuart, Iglesias, Carmen Lopez, van de Wetering, Willine J., Heinz, Maria C., van Ineveld, Ravian L., van Kleef, Regina G.D.M., Begthel, Harry, Korving, Jeroen, Bar-Ephraim, Yotam E., Getreuer, Walter, Rios, Anne C., Westerink, Remco H.S., Snippert, Hugo J.G., van Oudenaarden, Alexander, Peters, Peter J., Vonk, Freek J., Kool, Jeroen, Richardson, Michael K., Casewell, Nicholas R., Clevers, Hans
Published in Cell (23.01.2020)
Published in Cell (23.01.2020)
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Efficacy and safety in early-phase clinical trials for refractory colorectal cancer: A meta-analysis
Smabers, Lidwien P., Huismans, Maarten A., van Nieuwenhuijzen, Niels, Minnema, Monique C., Kranenburg, Onno, Koopman, Miriam, Snippert, Hugo J.G., May, Anne M., Roodhart, Jeanine M.L.
Published in European journal of cancer (1990) (01.11.2024)
Published in European journal of cancer (1990) (01.11.2024)
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Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
Bollen, Yannik, Stelloo, Ellen, van Leenen, Petra, van den Bos, Myrna, Ponsioen, Bas, Lu, Bingxin, van Roosmalen, Markus J., Bolhaqueiro, Ana C. F., Kimberley, Christopher, Mossner, Maximilian, Cross, William C. H., Besselink, Nicolle J. M., van der Roest, Bastiaan, Boymans, Sander, Oost, Koen C., de Vries, Sippe G., Rehmann, Holger, Cuppen, Edwin, Lens, Susanne M. A., Kops, Geert J. P. L., Kloosterman, Wigard P., Terstappen, Leon W. M. M., Barnes, Chris P., Sottoriva, Andrea, Graham, Trevor A., Snippert, Hugo J. G.
Published in Nature genetics (01.08.2021)
Published in Nature genetics (01.08.2021)
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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
Mertens, Sander, Huismans, Maarten A., Verissimo, Carla S., Ponsioen, Bas, Overmeer, Rene, Proost, Natalie, van Tellingen, Olaf, van de Ven, Marieke, Begthel, Harry, Boj, Sylvia F., Clevers, Hans, Roodhart, Jeanine M.L., Bos, Johannes L., Snippert, Hugo J.G.
Published in Cell reports (Cambridge) (25.04.2023)
Published in Cell reports (Cambridge) (25.04.2023)
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Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction
Chen, Jia-Yun, Hug, Clemens, Reyes, José, Tian, Chengzhe, Gerosa, Luca, Fröhlich, Fabian, Ponsioen, Bas, Snippert, Hugo J.G., Spencer, Sabrina L., Jambhekar, Ashwini, Sorger, Peter K., Lahav, Galit
Published in Cell reports (Cambridge) (28.03.2023)
Published in Cell reports (Cambridge) (28.03.2023)
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Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
Kayhanian, Hamzeh, Cross, William, van der Horst, Suzanne E. M., Barmpoutis, Panagiotis, Lakatos, Eszter, Caravagna, Giulio, Zapata, Luis, Van Hoeck, Arne, Middelkamp, Sjors, Litchfield, Kevin, Steele, Christopher, Waddingham, William, Patel, Dominic, Milite, Salvatore, Jin, Chen, Baker, Ann-Marie, Alexander, Daniel C., Khan, Khurum, Hochhauser, Daniel, Novelli, Marco, Werner, Benjamin, van Boxtel, Ruben, Hageman, Joris H., Buissant des Amorie, Julian R., Linares, Josep, Ligtenberg, Marjolijn J. L., Nagtegaal, Iris D., Laclé, Miangela M., Moons, Leon M. G., Brosens, Lodewijk A. A., Pillay, Nischalan, Sottoriva, Andrea, Graham, Trevor A., Rodriguez-Justo, Manuel, Shiu, Kai-Keen, Snippert, Hugo J. G., Jansen, Marnix
Published in Nature genetics (01.07.2024)
Published in Nature genetics (01.07.2024)
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Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity
Stangl, Christina, Post, Jasmin B, van Roosmalen, Markus J, Hami, Nizar, Verlaan-Klink, Ingrid, Vos, Harmjan R, van Es, Robert M, Koudijs, Marco J, Voest, Emile E, Snippert, Hugo J G, Kloosterman, W P
Published in Molecular cancer research (01.04.2020)
Published in Molecular cancer research (01.04.2020)
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Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants
Post, Jasmin B, Roodhart, Jeanine M L, Snippert, Hugo J G
Published in Trends in cancer (01.02.2020)
Published in Trends in cancer (01.02.2020)
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Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene
Oost, Koen C., van Voorthuijsen, Lisa, Fumagalli, Arianna, Lindeboom, Rik G.H., Sprangers, Joep, Omerzu, Manja, Rodriguez-Colman, Maria J., Heinz, Maria C., Verlaan-Klink, Ingrid, Maurice, Madelon M., Burgering, Boudewijn M.T., van Rheenen, Jacco, Vermeulen, Michiel, Snippert, Hugo J.G.
Published in Cell reports (Cambridge) (06.02.2018)
Published in Cell reports (Cambridge) (06.02.2018)
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