Widespread seasonal gene expression reveals annual differences in human immunity and physiology
Dopico, Xaquin Castro, Evangelou, Marina, Ferreira, Ricardo C., Guo, Hui, Pekalski, Marcin L., Smyth, Deborah J., Cooper, Nicholas, Burren, Oliver S., Fulford, Anthony J., Hennig, Branwen J., Prentice, Andrew M., Ziegler, Anette-G., Bonifacio, Ezio, Wallace, Chris, Todd, John A.
Published in Nature communications (12.05.2015)
Published in Nature communications (12.05.2015)
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Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases
Plagnol, Vincent, Howson, Joanna M M, Smyth, Deborah J, Walker, Neil, Hafler, Jason P, Wallace, Chris, Stevens, Helen, Jackson, Laura, Simmonds, Matthew J, Bingley, Polly J, Gough, Stephen C, Todd, John A
Published in PLoS genetics (01.08.2011)
Published in PLoS genetics (01.08.2011)
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Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Cano-Gamez, Eddie, Soskic, Blagoje, Roumeliotis, Theodoros I., So, Ernest, Smyth, Deborah J., Baldrighi, Marta, Willé, David, Nakic, Nikolina, Esparza-Gordillo, Jorge, Larminie, Christopher G. C., Bronson, Paola G., Tough, David F., Rowan, Wendy C., Choudhary, Jyoti S., Trynka, Gosia
Published in Nature communications (14.04.2020)
Published in Nature communications (14.04.2020)
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Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
Ferreira, Ricardo C, Freitag, Daniel F, Cutler, Antony J, Howson, Joanna M M, Rainbow, Daniel B, Smyth, Deborah J, Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M, Pekalski, Marcin L, Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S, Butterworth, Adam S, Malarstig, Anders, Danesh, John, Todd, John A
Published in PLoS genetics (01.04.2013)
Published in PLoS genetics (01.04.2013)
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Journal Article
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Ambridge, Kirsty, Ke, Ziying, Matte, Julie C., Bossini-Castillo, Lara, Kaplanis, Joanna, Ramirez-Navarro, Lucia, Lorenc, Anna, Nakic, Nikolina, Esparza-Gordillo, Jorge, Rowan, Wendy, Wille, David, Tough, David F., Bronson, Paola G., Trynka, Gosia
Published in Nature genetics (01.06.2022)
Published in Nature genetics (01.06.2022)
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Journal Article
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Rowan, Wendy C., Nakic, Nikolina, Esparza-Gordillo, Jorge, Bossini-Castillo, Lara, Tough, David F., Larminie, Christopher G. C., Bronson, Paola G., Willé, David, Trynka, Gosia
Published in Nature genetics (01.10.2019)
Published in Nature genetics (01.10.2019)
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A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
FERREIRA, Ricardo C, HUI GUO, LYONS, Paul A, SMITH, Kenneth G. C, ACHENBACH, Peter, BEYERLEIN, Andreas, DUNGER, David B, CLAYTON, David G, WICKER, Linda S, TODD, John A, BONIFACIO, Ezio, WALLACE, Chris, COULSON, Richard M. R, ZIEGLER, Anette-G, SMYTH, Deborah J, PEKALSKI, Marcin L, BURREN, Oliver S, CUTLER, Antony J, DOECKE, James D, FLINT, Shaun, MCKINNEY, Eoin F
Published in Diabetes (New York, N.Y.) (01.07.2014)
Published in Diabetes (New York, N.Y.) (01.07.2014)
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Journal Article
Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease
Smyth, Deborah J, Plagnol, Vincent, Walker, Neil M, Cooper, Jason D, Downes, Kate, Yang, Jennie H.M, Howson, Joanna M.M, Stevens, Helen, McManus, Ross, Wijmenga, Cisca, Heap, Graham A, Dubois, Patrick C, Clayton, David G, Hunt, Karen A, van Heel, David A, Todd, John A
Published in The New England journal of medicine (25.12.2008)
Published in The New England journal of medicine (25.12.2008)
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Journal Article
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
Cooper, Jason D, Smyth, Deborah J, Smiles, Adam M, Plagnol, Vincent, Walker, Neil M, Allen, James E, Downes, Kate, Barrett, Jeffrey C, Healy, Barry C, Mychaleckyj, Josyf C, Warram, James H, Todd, John A
Published in Nature genetics (01.12.2008)
Published in Nature genetics (01.12.2008)
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Journal Article
Reduced expression of IFIH1 is protective for type 1 diabetes
Downes, Kate, Pekalski, Marcin, Angus, Karen L, Hardy, Matthew, Nutland, Sarah, Smyth, Deborah J, Walker, Neil M, Wallace, Chris, Todd, John A
Published in PloS one (09.09.2010)
Published in PloS one (09.09.2010)
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Journal Article
Detecting acute distress and risk of future psychological morbidity in critically ill patients: validation of the intensive care psychological assessment tool
Wade, Dorothy M, Hankins, Matthew, Smyth, Deborah A, Rhone, Elijah E, Mythen, Michael G, Howell, David C J, Weinman, John A
Published in Critical care (London, England) (24.09.2014)
Published in Critical care (London, England) (24.09.2014)
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Journal Article
Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping
Wallace, Chris, Cutler, Antony J, Pontikos, Nikolas, Pekalski, Marcin L, Burren, Oliver S, Cooper, Jason D, García, Arcadio Rubio, Ferreira, Ricardo C, Guo, Hui, Walker, Neil M, Smyth, Deborah J, Rich, Stephen S, Onengut-Gumuscu, Suna, Sawcer, Stephen J, Ban, Maria, Richardson, Sylvia, Todd, John A, Wicker, Linda S
Published in PLoS genetics (01.06.2015)
Published in PLoS genetics (01.06.2015)
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IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients
Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Cutler, Antony J., Dopico, Xaquin Castro, Smyth, Deborah J., Mashar, Meghavi, Schuilenburg, Helen, Walker, Neil M., Dunger, David B., Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.
Published in Diabetologia (01.04.2015)
Published in Diabetologia (01.04.2015)
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Journal Article
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase ( IFIH1 ) region
Todd, John A, Smyth, Deborah J, Cooper, Jason D, Bailey, Rebecca, Field, Sarah, Burren, Oliver, Smink, Luc J, Guja, Cristian, Ionescu-Tirgoviste, Constantin, Widmer, Barry, Dunger, David B, Savage, David A, Walker, Neil M, Clayton, David G
Published in Nature genetics (01.06.2006)
Published in Nature genetics (01.06.2006)
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Journal Article
Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes
COOPER, Jason D, SMYTH, Deborah J, SPECTOR, Timothy D, OUWEHAND, Willem H, WANG, Thomas J, BADENHOOP, Klaus, TODD, John A, WALKER, Neil M, STEVENS, Helen, BURREN, Oliver S, WALLACE, Chris, GREISSL, Christopher, RAMOS-LOPEZ, Elizabeth, HYPPÖNEN, Elina, DUNGER, David B
Published in Diabetes (New York, N.Y.) (01.05.2011)
Published in Diabetes (New York, N.Y.) (01.05.2011)
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Journal Article
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Bailey, Rebecca, Smyth, Deborah J, Atkinson, Mark, Plagnol, Vincent, Brusko, Todd, Lowe, Christopher E, Field, Sarah, Wicker, Linda S, Bourget, Kirsi, Walker, Neil M, Todd, John A, Clayton, David G, Cooper, Jason D
Published in Nature genetics (01.09.2007)
Published in Nature genetics (01.09.2007)
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Journal Article
FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection
Smyth, Deborah J, Cooper, Jason D, Howson, Joanna M M, Clarke, Pamela, Downes, Kate, Mistry, Trupti, Stevens, Helen, Walker, Neil M, Todd, John A
Published in Diabetes (New York, N.Y.) (01.11.2011)
Published in Diabetes (New York, N.Y.) (01.11.2011)
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Journal Article
Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity
Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Rainbow, Daniel B., Yang, Xin, Cutler, Antony J., Oliveira, Joao, Castro Dopico, Xaquin, Smyth, Deborah J., Savinykh, Natalia, Mashar, Meghavi, Vyse, Tim J., Dunger, David B., Baxendale, Helen, Chandra, Anita, Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.
Published in Journal of autoimmunity (01.11.2017)
Published in Journal of autoimmunity (01.11.2017)
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Journal Article
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes
WALLACE, Chris, ROTIVAL, Maxime, TODD, John A, CLAYTON, David G, BLANKENBERG, Stefan, COOPER, Jason D, RICE, Catherine M, YANG, Jennie H. M, MCNEILL, Mhairi, SMYTH, Deborah J, NIBLETT, David, CAMBIEN, François, TIRET, Laurence
Published in Human molecular genetics (15.06.2012)
Published in Human molecular genetics (15.06.2012)
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