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Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
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New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
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Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer
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Published in Nature communications (29.03.2022)
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MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy
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Published in Cancer research (Chicago, Ill.) (01.11.2017)
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Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport
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Published in Molecular cancer therapeutics (01.12.2014)
Published in Molecular cancer therapeutics (01.12.2014)
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Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers
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Published in Nature communications (19.03.2021)
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Basal and Treatment-Induced Activation of AKT Mediates Resistance to Cell Death by AZD6244 (ARRY-142886) in Braf-Mutant Human Cutaneous Melanoma Cells
VASHISHT GOPAL, Y. N, WANLENG DENG, WOODMAN, Scott E, KOMUROV, Kakajan, RAM, Prahlad, SMITH, Paul D, DAVIES, Michael A
Published in Cancer research (Chicago, Ill.) (01.11.2010)
Published in Cancer research (Chicago, Ill.) (01.11.2010)
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Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity
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Published in Oncotarget (19.09.2017)
Published in Oncotarget (19.09.2017)
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Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations
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Published in Cancer research (Chicago, Ill.) (15.05.2020)
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Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
Sale, Matthew J., Minihane, Emma, Monks, Noel R., Gilley, Rebecca, Richards, Frances M., Schifferli, Kevin P., Andersen, Courtney L., Davies, Emma J., Vicente, Mario Aladren, Ozono, Eiko, Markovets, Aleksandra, Dry, Jonathan R., Drew, Lisa, Flemington, Vikki, Proia, Theresa, Jodrell, Duncan I., Smith, Paul D., Cook, Simon J.
Published in Nature communications (14.11.2019)
Published in Nature communications (14.11.2019)
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Health Literacy and Health-Related Quality of Life Among a Population-Based Sample of Cancer Patients
Halverson, Julie L., Martinez-Donate, Ana P., Palta, Mari, Leal, Ticiana, Lubner, Sam, Walsh, Matthew C., Schaaf Strickland, Jeanne, Smith, Paul D., Trentham-Dietz, Amy
Published in Journal of health communication (02.11.2015)
Published in Journal of health communication (02.11.2015)
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Antitumor activity in RAS-driven tumors by blocking AKT and MEK
Tolcher, Anthony W, Khan, Khurum, Ong, Michael, Banerji, Udai, Papadimitrakopoulou, Vassiliki, Gandara, David R, Patnaik, Amita, Baird, Richard D, Olmos, David, Garrett, Christopher R, Skolnik, Jeffrey M, Rubin, Eric H, Smith, Paul D, Huang, Pearl, Learoyd, Maria, Shannon, Keith A, Morosky, Anne, Tetteh, Ernestina, Jou, Ying-Ming, Papadopoulos, Kyriakos P, Moreno, Victor, Kaiser, Brianne, Yap, Timothy A, Yan, Li, de Bono, Johann S
Published in Clinical cancer research (15.02.2015)
Published in Clinical cancer research (15.02.2015)
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Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non―Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models
JINGCHUAN ZHANG, LIN ZHANG, ZHENGWEI DONG, GUANSHAN ZHU, ZILIANG QIAN, LILI TANG, PING ZHAN, QUNSHENG JI, KILGOUR, Elaine, SMITH, Paul D, NIGEL BROOKS, A, THOMAS, Roman K, XINYING SU, GAVINE, Paul R, MING LI, LIANG XIE, MALCHERS, Florian, SHUQIONG FAN, XIAOLU YIN, YANPING XU, KUNJI LIU
Published in Clinical cancer research (15.12.2012)
Published in Clinical cancer research (15.12.2012)
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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer
Choi, Hyejin, Deng, Jiehui, Li, Shuai, Silk, Tarik, Dong, Lauren, Brea, Elliott J., Houghton, Sean, Redmond, David, Zhong, Hong, Boiarsky, Jonathan, Akbay, Esra A., Smith, Paul D., Merghoub, Taha, Wong, Kwok-Kin, Wolchok, Jedd D.
Published in Cell reports (Cambridge) (16.04.2019)
Published in Cell reports (Cambridge) (16.04.2019)
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MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model
Bartholomeusz, Chandra, Xie, Xuemei, Pitner, Mary Kathryn, Kondo, Kimie, Dadbin, Ali, Lee, Jangsoon, Saso, Hitomi, Smith, Paul D, Dalby, Kevin N, Ueno, Naoto T
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models
Davies, Barry R, Logie, Armelle, McKay, Jennifer S, Martin, Paul, Steele, Samantha, Jenkins, Richard, Cockerill, Mark, Cartlidge, Sue, Smith, Paul D
Published in Molecular cancer therapeutics (01.08.2007)
Published in Molecular cancer therapeutics (01.08.2007)
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