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SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition
Kim, Eunhee, Ilagan, Janine O., Liang, Yang, Daubner, Gerrit M., Lee, Stanley C.-W., Ramakrishnan, Aravind, Li, Yue, Chung, Young Rock, Micol, Jean-Baptiste, Murphy, Michele E., Cho, Hana, Kim, Min-Kyung, Zebari, Ahmad S., Aumann, Shlomzion, Park, Christopher Y., Buonamici, Silvia, Smith, Peter G., Deeg, H. Joachim, Lobry, Camille, Aifantis, Iannis, Modis, Yorgo, Allain, Frederic H.-T., Halene, Stephanie, Bradley, Robert K., Abdel-Wahab, Omar
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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
Seiler, Michael, Yoshimi, Akihide, Darman, Rachel, Chan, Betty, Keaney, Gregg, Thomas, Michael, Agrawal, Anant A, Caleb, Benjamin, Csibi, Alfredo, Sean, Eckley, Fekkes, Peter, Karr, Craig, Klimek, Virginia, Lai, George, Lee, Linda, Kumar, Pavan, Lee, Stanley Chun-Wei, Liu, Xiang, Mackenzie, Crystal, Meeske, Carol, Mizui, Yoshiharu, Padron, Eric, Park, Eunice, Pazolli, Ermira, Peng, Shouyong, Prajapati, Sudeep, Taylor, Justin, Teng, Teng, Wang, John, Warmuth, Markus, Yao, Huilan, Yu, Lihua, Zhu, Ping, Abdel-Wahab, Omar, Smith, Peter G, Buonamici, Silvia
Published in Nature medicine (01.04.2018)
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Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials
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Cretu, Constantin, Agrawal, Anant A., Cook, Andrew, Will, Cindy L., Fekkes, Peter, Smith, Peter G., Lührmann, Reinhard, Larsen, Nicholas, Buonamici, Silvia, Pena, Vladimir
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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point
Darman, Rachel B., Seiler, Michael, Agrawal, Anant A., Lim, Kian H., Peng, Shouyong, Aird, Daniel, Bailey, Suzanna L., Bhavsar, Erica B., Chan, Betty, Colla, Simona, Corson, Laura, Feala, Jacob, Fekkes, Peter, Ichikawa, Kana, Keaney, Gregg F., Lee, Linda, Kumar, Pavan, Kunii, Kaiko, MacKenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eun Sun, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael P., Tsai, Jennifer, Wang, John Y., Warmuth, Markus, Yang, Hui, Zhu, Ping, Garcia-Manero, Guillermo, Furman, Richard R., Yu, Lihua, Smith, Peter G., Buonamici, Silvia
Published in Cell reports (Cambridge) (03.11.2015)
Published in Cell reports (Cambridge) (03.11.2015)
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Patel, Minal K., Bergeri, Isabel, Bresee, Joseph S., Cowling, Benjamin J., Crowcroft, Natasha S., Fahmy, Kamal, Hirve, Siddhivinayak, Kang, Gagandeep, Katz, Mark A., Lanata, Claudio F., L'Azou Jackson, Maïna, Joshi, Sudhir, Lipsitch, Marc, Mwenda, Jason M., Nogareda, Francisco, Orenstein, Walter A., Ortiz, Justin R., Pebody, Richard, Schrag, Stephanie J., Smith, Peter G., Srikantiah, Padmini, Subissi, Lorenzo, Valenciano, Marta, Vaughn, David W., Verani, Jennifer R., Wilder-Smith, Annelies, Feikin, Daniel R.
Published in Vaccine (05.07.2021)
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Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations
Lee, Stanley Chun-Wei, North, Khrystyna, Kim, Eunhee, Jang, Eunjung, Obeng, Esther, Lu, Sydney X., Liu, Bo, Inoue, Daichi, Yoshimi, Akihide, Ki, Michelle, Yeo, Mirae, Zhang, Xiao Jing, Kim, Min Kyung, Cho, Hana, Chung, Young Rock, Taylor, Justin, Durham, Benjamin H., Kim, Young Joon, Pastore, Alessandro, Monette, Sebastien, Palacino, James, Seiler, Michael, Buonamici, Silvia, Smith, Peter G., Ebert, Benjamin L., Bradley, Robert K., Abdel-Wahab, Omar
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Published in PLoS medicine (07.08.2018)
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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action
Finci, Lorenzo I, Zhang, Xiaofeng, Huang, Xiuliang, Zhou, Qiang, Tsai, Jennifer, Teng, Teng, Agrawal, Anant, Chan, Betty, Irwin, Sean, Karr, Craig, Cook, Andrew, Zhu, Ping, Reynolds, Dominic, Smith, Peter G, Fekkes, Peter, Buonamici, Silvia, Larsen, Nicholas A
Published in Genes & development (01.02.2018)
Published in Genes & development (01.02.2018)
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Vekemans, Johan, Moorthy, Vasee, Giersing, Brigitta, Friede, Martin, Hombach, Joachim, Arora, Narendra, Modjarrad, Kayvon, Smith, Peter G., Karron, Ruth, Graham, Barney, Kaslow, David C.
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Joshi, Jaya Julie, Coffey, Heather, Corcoran, Erik, Tsai, Jennifer, Huang, Chia-Ling, Ichikawa, Kana, Prajapati, Sudeep, Hao, Ming-Hong, Bailey, Suzanna, Wu, Jeremy, Rimkunas, Victoria, Karr, Craig, Subramanian, Vanitha, Kumar, Pavan, MacKenzie, Crystal, Hurley, Raelene, Satoh, Takashi, Yu, Kun, Park, Eunice, Rioux, Nathalie, Kim, Amy, Lai, Weidong G, Yu, Lihua, Zhu, Ping, Buonamici, Silvia, Larsen, Nicholas, Fekkes, Peter, Wang, John, Warmuth, Markus, Reynolds, Dominic J, Smith, Peter G, Selvaraj, Anand
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Published in Cancer research (Chicago, Ill.) (15.12.2017)
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Wang, Lili, Brooks, Angela N., Fan, Jean, Wan, Youzhong, Gambe, Rutendo, Li, Shuqiang, Hergert, Sarah, Yin, Shanye, Freeman, Samuel S., Levin, Joshua Z., Fan, Lin, Seiler, Michael, Buonamici, Silvia, Smith, Peter G., Chau, Kevin F., Cibulskis, Carrie L., Zhang, Wandi, Rassenti, Laura Z., Ghia, Emanuela M., Kipps, Thomas J., Fernandes, Stacey, Bloch, Donald B., Kotliar, Dylan, Landau, Dan A., Shukla, Sachet A., Aster, Jon C., Reed, Robin, DeLuca, David S., Brown, Jennifer R., Neuberg, Donna, Getz, Gad, Livak, Kenneth J., Meyerson, Matthew M., Kharchenko, Peter V., Wu, Catherine J.
Published in Cancer cell (14.11.2016)
Published in Cancer cell (14.11.2016)
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Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Zhenhua Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter G., Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping
Published in Nature communications (11.01.2019)
Published in Nature communications (11.01.2019)
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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
Teng, Teng, Tsai, Jennifer HC, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Prajapati, Sudeep, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Gerard, Baudouin, Karr, Craig, Korpal, Manav, Liu, Xiang, T. Lowe, Jason, Mizui, Yoshiharu, Palacino, James, Park, Eunice, Smith, Peter G., Subramanian, Vanitha, Wu, Zhenhua Jeremy, Zou, Jian, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping
Published in Nature communications (25.05.2017)
Published in Nature communications (25.05.2017)
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