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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
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Published in Nature medicine (01.02.2013)
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Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity
Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in Journal of medicinal chemistry (12.03.2015)
Published in Journal of medicinal chemistry (12.03.2015)
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Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors
Phillips, Darren C, Buchanan, Fritz G, Cheng, Dong, Solomon, Larry R, Xiao, Yu, Xue, John, Tahir, Stephen K, Smith, Morey L, Zhang, Haichao, Widomski, Deborah, Abraham, Vivek C, Xu, Nan, Liu, Zhihong, Zhou, Li, DiGiammarino, Enrico, Lu, Xin, Rudra-Ganguly, Nandini, Trela, Bruce, Morgan-Lappe, Susan E
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Published in Cancer research (Chicago, Ill.) (15.06.2021)
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Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity
Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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Development of a flow cytometric method for quantification of BCL‐2 family members in chronic lymphocytic leukemia and correlation with sensitivity to BCL‐2 family inhibitors
Smith, Morey L., Chyla, Brenda, McKeegan, Evelyn, Tahir, Stephen K.
Published in Cytometry. Part B, Clinical cytometry (01.09.2017)
Published in Cytometry. Part B, Clinical cytometry (01.09.2017)
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Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors
Tong, Yunsong, Florjancic, Alan S, Clark, Rick F, Lai, Chunqiu, Mastracchio, Anthony, Zhu, Gui-dong, Smith, Morey L, Kovar, Peter J, Shaw, Bailin, Albert, Daniel H, Qiu, Wei, Longenecker, Kenton L, Liu, Xiaoqin, Olson, Amanda M, Osterling, Donald J, Tahir, Stephen K, Phillips, Darren C, Leverson, Joel D, Souers, Andrew J, Penning, Thomas D
Published in ACS medicinal chemistry letters (08.07.2021)
Published in ACS medicinal chemistry letters (08.07.2021)
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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity
Sleebs, Brad E, Czabotar, Peter E, Fairbrother, Wayne J, Fairlie, W. Douglas, Flygare, John A, Huang, David C. S, Kersten, Wilhelmus J. A, Koehler, Michael F. T, Lessene, Guillaume, Lowes, Kym, Parisot, John P, Smith, Brian J, Smith, Morey L, Souers, Andrew J, Street, Ian P, Yang, Hong, Baell, Jonathan B
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor
Wang, Le, Doherty, George A, Judd, Andrew S, Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R, Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R, Wang, Xilu, Wendt, Michael D, Flygare, John A, Catron, Nathaniel D, Judge, Russell A, Park, Chang H, Shekhar, Shashank, Phillips, Darren C, Nimmer, Paul, Smith, Morey L, Tahir, Stephen K, Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N, Mitten, Michael J, Boghaert, Erwin R, Gao, Wenqing, Kovar, Peter, Choo, Edna F, Diaz, Dolores, Fairbrother, Wayne J, Elmore, Steven W, Sampath, Deepak, Leverson, Joel D, Souers, Andrew James
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Correction to Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity
Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in Journal of medicinal chemistry (14.05.2015)
Published in Journal of medicinal chemistry (14.05.2015)
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Clearance of systemic hematologic tumors by venetoclax (Abt‐199) and navitoclax
Ackler, Scott, Oleksijew, Anatol, Chen, Jun, Chyla, Brenda J., Clarin, Jerry, Foster, Kelly, McGonigal, Thomas, Mishra, Sasmita, Schlessinger, Sally, Smith, Morey L., Tahir, Stephen K., Leverson, Joel D., Souers, Andrew J., Boghaert, Erwin R., Hickson, Jonathan
Published in Pharmacology research & perspectives (01.10.2015)
Published in Pharmacology research & perspectives (01.10.2015)
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Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression
Chen, Yung-Wu, Smith, Morey L, Sheets, Michael, Ballaron, Steve, Trevillyan, James M, Burke, Sandra E, Rosenberg, Teresa, Henry, Cindy, Wagner, Rolf, Bauch, Joy, Marsh, Kennan, Fey, Thomas A, Hsieh, Gin, Gauvin, Donna, Mollison, Karl W, Carter, George W, Djuric, Stevan W
Published in Journal of cardiovascular pharmacology (01.04.2007)
Published in Journal of cardiovascular pharmacology (01.04.2007)
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Comptes rendus. Sam White
Morey Smith, Sean, Vannini, Laurent
Published in Annales : histoire, sciences sociales (French ed.) (2022)
Published in Annales : histoire, sciences sociales (French ed.) (2022)
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T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC
Haasch, Deanna, Chen, Yung-Wu, Reilly, Regina M, Grace Chiou, X, Koterski, Sandra, Smith, Morey L, Kroeger, Paul, McWeeny, Kerri, Halbert, Donald N, Mollison, Karl W, Djuric, Stevan W, Trevillyan, James M
Published in Cellular immunology (01.05.2002)
Published in Cellular immunology (01.05.2002)
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The Bcl-2/Bcl-XL/Bcl-w Inhibitor, Navitoclax, Enhances the Activity of Chemotherapeutic Agents In Vitro and In Vivo
Chen, Jun, Jin, Sha, Abraham, Vivek, Huang, Xiaoli, Liu, Bernard, Mitten, Michael J., Nimmer, Paul, Lin, Xiaoyu, Smith, Morey, Shen, Yu, Shoemaker, Alexander R., Tahir, Stephen K., Zhang, Haichao, Ackler, Scott L., Rosenberg, Saul H., Maecker, Heather, Sampath, Deepak, Leverson, Joel D., Tse, Chris, Elmore, Steven W.
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
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Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds
Trevillyan, James M., Chiou, X. Grace, Chen, Yung-Wu, Ballaron, Stephen J., Sheets, Michael P., Smith, Morey L., Wiedeman, Paul E., Warrior, Usha, Wilkins, Julie, Gubbins, Earl J., Gagne, Gerard D., Fagerland, Jane, Carter, George W., Luly, Jay R., Mollison, Karl W., Djuric, Stevan W.
Published in The Journal of biological chemistry (21.12.2001)
Published in The Journal of biological chemistry (21.12.2001)
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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Leverson, Joel D, Phillips, Darren C, Mitten, Michael J, Boghaert, Erwin R, Diaz, Dolores, Tahir, Stephen K, Belmont, Lisa D, Nimmer, Paul, Xiao, Yu, Ma, Xiaoju Max, Lowes, Kym N, Kovar, Peter, Chen, Jun, Jin, Sha, Smith, Morey, Xue, John, Zhang, Haichao, Oleksijew, Anatol, Magoc, Terrance J, Vaidya, Kedar S, Albert, Daniel H, Tarrant, Jacqueline M, La, Nghi, Wang, Le, Tao, Zhi-Fu, Wendt, Michael D, Sampath, Deepak, Rosenberg, Saul H, Tse, Chris, Huang, David C S, Fairbrother, Wayne J, Elmore, Steven W, Souers, Andrew J
Published in Science translational medicine (18.03.2015)
Published in Science translational medicine (18.03.2015)
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