Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides
Smith, Mark E. B, Schumacher, Felix F, Ryan, Chris P, Tedaldi, Lauren M, Papaioannou, Danai, Waksman, Gabriel, Caddick, Stephen, Baker, James R
Published in Journal of the American Chemical Society (17.02.2010)
Published in Journal of the American Chemical Society (17.02.2010)
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Journal Article
Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment
Bryden, Francesca, Maruani, Antoine, Savoie, Huguette, Chudasama, Vijay, Smith, Mark E. B, Caddick, Stephen, Boyle, Ross W
Published in Bioconjugate chemistry (19.03.2014)
Published in Bioconjugate chemistry (19.03.2014)
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Journal Article
Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation
Castaneda, Lourdes, Maruani, Antoine, Schumacher, Felix F., Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A., Baker, James R., Smith, Mark E. B., Caddick, Stephen
Published in Chemical communications (Cambridge, England) (01.01.2013)
Published in Chemical communications (Cambridge, England) (01.01.2013)
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Journal Article
Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)
Nunes, João P M, Morais, Maurício, Vassileva, Vessela, Robinson, Eifion, Rajkumar, Vineeth S, Smith, Mark E B, Pedley, R Barbara, Caddick, Stephen, Baker, James R, Chudasama, Vijay
Published in Chemical communications (Cambridge, England) (07.07.2015)
Published in Chemical communications (Cambridge, England) (07.07.2015)
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Journal Article
Directed evolution to re-adapt a co-evolved network within an enzyme
Strafford, John, Payongsri, Panwajee, Hibbert, Edward G., Morris, Phattaraporn, Batth, Sukhjeet S., Steadman, David, Smith, Mark E.B., Ward, John M., Hailes, Helen C., Dalby, Paul A.
Published in Journal of biotechnology (01.01.2012)
Published in Journal of biotechnology (01.01.2012)
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Journal Article
Homogeneous Bispecifics by Disulfide Bridging
Hull, Elizabeth A, Livanos, Maria, Miranda, Enrique, Smith, Mark E. B, Chester, Kerry A, Baker, James R
Published in Bioconjugate chemistry (20.08.2014)
Published in Bioconjugate chemistry (20.08.2014)
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Journal Article
Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis
Ryan, Chris P., Smith, Mark E. B., Schumacher, Felix F., Grohmann, Dina, Papaioannou, Danai, Waksman, Gabriel, Werner, Finn, Baker, James R., Caddick, Stephen
Published in Chemical communications (Cambridge, England) (21.05.2011)
Published in Chemical communications (Cambridge, England) (21.05.2011)
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Journal Article
Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis
Morais, Mauricio, Nunes, Joao P. M., Karu, Kersti, Forte, Nafsika, Benni, Irene, Smith, Mark E. B., Caddick, Stephen, Chudasama, Vijay, Baker, James R.
Published in Organic & biomolecular chemistry (05.04.2017)
Published in Organic & biomolecular chemistry (05.04.2017)
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Journal Article
Correction: Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis
Morais, Maurício, Nunes, João P. M, Karu, Kersti, Forte, Nafsika, Benni, Irene, Smith, Mark E. B, Caddick, Stephen, Chudasama, Vijay, Baker, James R
Published in Organic & biomolecular chemistry (08.04.2021)
Published in Organic & biomolecular chemistry (08.04.2021)
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Journal Article
A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
Morgan, Rachel E, Chudasama, Vijay, Moody, Paul, Smith, Mark E B, Caddick, Stephen
Published in Organic & biomolecular chemistry (14.04.2015)
Published in Organic & biomolecular chemistry (14.04.2015)
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Journal Article
A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine
Smith, Mark E B, Caspersen, Mikael B, Robinson, Eifion, Morais, Maurício, Maruani, Antoine, Nunes, João P M, Nicholls, Karl, Saxton, Malcolm J, Caddick, Stephen, Baker, James R, Chudasama, Vijay
Published in Organic & biomolecular chemistry (07.08.2015)
Published in Organic & biomolecular chemistry (07.08.2015)
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Journal Article
Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody
Robinson, Eifion, Nunes, João P. M., Vassileva, Vessela, Maruani, Antoine, Nogueira, João C. F., Smith, Mark E. B., Pedley, R. Barbara, Caddick, Stephen, Baker, James R., Chudasama, Vijay
Published in RSC advances (01.01.2017)
Published in RSC advances (01.01.2017)
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Journal Article
In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation
Schumacher, Felix F, Nobles, Muriel, Ryan, Chris P, Smith, Mark E. B, Tinker, Andrew, Caddick, Stephen, Baker, James R
Published in Bioconjugate chemistry (16.02.2011)
Published in Bioconjugate chemistry (16.02.2011)
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Journal Article