Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease
Hallett, Penelope J., Deleidi, Michela, Astradsson, Arnar, Smith, Gaynor A., Cooper, Oliver, Osborn, Teresia M., Sundberg, Maria, Moore, Michele A., Perez-Torres, Eduardo, Brownell, Anna-Liisa, Schumacher, James M., Spealman, Roger D., Isacson, Ole
Published in Cell stem cell (05.03.2015)
Published in Cell stem cell (05.03.2015)
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Journal Article
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
Malik, Bilal R, Maddison, Daniel C, Smith, Gaynor A, Peters, Owen M
Published in Molecular brain (29.11.2019)
Published in Molecular brain (29.11.2019)
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Journal Article
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
Rocha, Emily M, Smith, Gaynor A, Park, Eric, Cao, Hongmei, Brown, Eilish, Hayes, Melissa A, Beagan, Jonathan, McLean, Jesse R, Izen, Sarah C, Perez-Torres, Eduardo, Hallett, Penelope J, Isacson, Ole
Published in Neurobiology of disease (01.10.2015)
Published in Neurobiology of disease (01.10.2015)
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Journal Article
A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C)
Smith, Gaynor A, Rocha, Emily M, Rooney, Thomas, Barneoud, Pascal, McLean, Jesse R, Beagan, Jonathan, Osborn, Teresia, Coimbra, Madeleine, Luo, Yongyi, Hallett, Penelope J, Isacson, Ole
Published in PloS one (27.03.2015)
Published in PloS one (27.03.2015)
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Journal Article
Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease
Peters, Owen M., Weiss, Alexandra, Metterville, Jake, Song, Lina, Logan, Robert, Smith, Gaynor A., Schwarzschild, Michael A., Mueller, Christian, Brown, Robert H., Freeman, Marc
Published in Neurobiology of disease (01.07.2021)
Published in Neurobiology of disease (01.07.2021)
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Journal Article
Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC‐, hiPSC‐, and Non‐Human Primate iPSC‐Derived Dopaminergic Neurons
Sundberg, Maria, Bogetofte, Helle, Lawson, Tristan, Jansson, Johan, Smith, Gaynor, Astradsson, Arnar, Moore, Michele, Osborn, Teresia, Cooper, Oliver, Spealman, Roger, Hallett, Penelope, Isacson, Ole
Published in Stem cells (Dayton, Ohio) (01.08.2013)
Published in Stem cells (Dayton, Ohio) (01.08.2013)
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Journal Article
Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation
Smith, Gaynor A., Lin, Tzu-Huai, Sheehan, Amy E., Van der Goes van Naters, Wynand, Neukomm, Lukas J., Graves, Hillary K., Bis-Brewer, Dana M., Züchner, Stephan, Freeman, Marc R.
Published in Neuron (Cambridge, Mass.) (03.07.2019)
Published in Neuron (Cambridge, Mass.) (03.07.2019)
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Journal Article
New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms
Kors, Suzan, Schuster, Martin, Maddison, Daniel C., Kilaru, Sreedhar, Schrader, Tina A., Costello, Joseph L., Islinger, Markus, Smith, Gaynor A., Schrader, Michael
Published in Biochimica et biophysica acta. Molecular cell research (01.12.2024)
Published in Biochimica et biophysica acta. Molecular cell research (01.12.2024)
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Journal Article
Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice
Rocha, Emily M, Smith, Gaynor A, Park, Eric, Cao, Hongmei, Graham, Anne-Renee, Brown, Eilish, McLean, Jesse R, Hayes, Melissa A, Beagan, Jonathan, Izen, Sarah C, Perez-Torres, Eduardo, Hallett, Penelope J, Isacson, Ole
Published in Antioxidants & redox signaling (20.08.2015)
Published in Antioxidants & redox signaling (20.08.2015)
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Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites
Heuer, Andreas, Smith, Gaynor A., Lelos, Mariah J., Lane, Emma L., Dunnett, Stephen B.
Published in Behavioural brain research (01.03.2012)
Published in Behavioural brain research (01.03.2012)
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Journal Article
Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection
McLean, Jesse R., Smith, Gaynor A., Rocha, Emily M., Hayes, Melissa A., Beagan, Jonathan A., Hallett, Penelope J., Isacson, Ole
Published in Neuroscience letters (25.07.2014)
Published in Neuroscience letters (25.07.2014)
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Journal Article
TSG101 negatively regulates mitochondrial biogenesis in axons
Lin, Tzu-Huai, Bis-Brewer, Dana M., Sheehan, Amy E., Townsend, Louise N., Maddison, Daniel C., Züchner, Stephan, Smith, Gaynor A., Freeman, Marc R.
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2021)
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Journal Article
Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease
Smith, Gaynor A, Rocha, Emily M, McLean, Jesse R, Hayes, Melissa A, Izen, Sarah C, Isacson, Ole, Hallett, Penelope J
Published in Human molecular genetics (01.09.2014)
Published in Human molecular genetics (01.09.2014)
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Journal Article
How neurons maintain their axons long-term: an integrated view of axon biology and pathology
Smith, Gaynor, Sweeney, Sean T, O'Kane, Cahir J, Prokop, Andreas
Published in Frontiers in neuroscience (26.07.2023)
Published in Frontiers in neuroscience (26.07.2023)
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Journal Article
Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
Rees, Daniel, Beynon, Amy L., Lelos, Mariah J., Smith, Gaynor A., Roberts, Luke D., Phelps, Lyndsey, Dunnett, Stephen B., Morgan, Alwena H., Brown, Rowan M., Wells, Timothy, Davies, Jeffrey S.
Published in Cellular and molecular neurobiology (01.07.2023)
Published in Cellular and molecular neurobiology (01.07.2023)
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Journal Article
Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease
Davies, Sian E, Hallett, Penelope J, Moens, Thomas, Smith, Gaynor, Mangano, Emily, Kim, Hyoung Tae, Goldberg, Alfred L, Liu, Ji-Long, Isacson, Ole, Tofaris, George K
Published in Neurobiology of disease (01.04.2014)
Published in Neurobiology of disease (01.04.2014)
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