TLR3 agonism augments CD47 inhibition in acute myeloid leukemia
Ramsey, Haley E, Gorska, Agnieszka E, Smith, Brianna N, Monteith, Andrew J, Fuller, Londa, Arrate, Maria P, Savona, Michael R
Published in Haematologica (Roma) (28.12.2023)
Published in Haematologica (Roma) (28.12.2023)
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Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia
Cojocari, Dan, Smith, Brianna N, Purkal, Julie J, Arrate, Maria P, Huska, Jason D, Xiao, Yu, Gorska, Agnieszka, Hogdal, Leah J, Ramsey, Haley E, Boghaert, Erwin R, Phillips, Darren C, Savona, Michael R
Published in Haematologica (Roma) (01.04.2022)
Published in Haematologica (Roma) (01.04.2022)
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Selective inhibition of MCL1 overcomes venetoclax resistance in a murine model of myelodysplastic syndromes
Fischer, Melissa A, Song, Yuanbin, Arrate, Maria P, Gbyli, Rana, Villaume, Matthew T, Smith, Brianna N, Childress, Merrida A, Stricker, Thomas P, Halene, Stephanie, Savona, Michael R
Published in Haematologica (Roma) (01.02.2023)
Published in Haematologica (Roma) (01.02.2023)
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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
Howard, Gregory Caleb, Wang, Jing, Rose, Kristie L, Jones, Camden, Patel, Purvi, Tsui, Tina, Florian, Andrea C, Vlach, Logan, Lorey, Shelly L, Grieb, Brian C, Smith, Brianna N, Slota, Macey J, Reynolds, Elizabeth M, Goswami, Soumita, Savona, Michael R, Mason, Frank M, Lee, Taekyu, Fesik, Stephen, Liu, Qi, Tansey, William P
Published in eLife (29.04.2024)
Published in eLife (29.04.2024)
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Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
Monteith, Andrew J, Ramsey, Haley E, Silver, Alexander J, Brown, Donovan, Greenwood, Dalton, Smith, Brianna N, Wise, Ashley D, Liu, Juan, Olmstead, Sarah D, Watke, Jackson, Arrate, Maria P, Gorska, Agnieszka E, Fuller, Londa, Locasale, Jason W, Stubbs, Matthew C, Rathmell, Jeffrey C, Savona, Michael R
Published in Cancer research (Chicago, Ill.) (01.04.2024)
Published in Cancer research (Chicago, Ill.) (01.04.2024)
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Challenges in Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)
Smith, Brianna N., Savona, Michael, Komrokji, Rami S.
Published in Clinical lymphoma, myeloma and leukemia (01.01.2019)
Published in Clinical lymphoma, myeloma and leukemia (01.01.2019)
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The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib
Villaume, Matthew T., Arrate, M. Pia, Ramsey, Haley E., Sunthankar, Kathryn I., Jenkins, Matthew T., Moyo, Tamara K., Smith, Brianna N., Fischer, Melissa A., Childress, Merrida A., Gorska, Agnieszka E., Ferrell, P. Brent, Savona, Michael R.
Published in Experimental hematology (01.05.2021)
Published in Experimental hematology (01.05.2021)
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Journal Article
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
Howard, Gregory C, Wang, Jing, Rose, Kristie L, Jones, Camden, Patel, Purvi, Tsui, Tina, Florian, Andrea C, Vlach, Logan, Lorey, Shelly L, Grieb, Brian C, Smith, Brianna N, Slota, Macey J, Reynolds, Elizabeth M, Goswami, Soumita, Savona, Michael R, Mason, Frank M, Lee, Taekyu, Fesik, Stephen W, Liu, Qi, Tansey, William P
Published in bioRxiv (10.01.2024)
Published in bioRxiv (10.01.2024)
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Journal Article
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies
Meyer, Christian T, Smith, Brianna N, Wang, Jing, Teuscher, Kevin B, Grieb, Brian C, Howard, Gregory C, Silver, Alexander J, Lorey, Shelly L, Stott, Gordon M, Moore, William J, Lee, Taekyu, Savona, Michael R, Weissmiller, April M, Liu, Qi, Quaranta, Vito, Fesik, Stephen W, Tansey, William P
Published in Proceedings of the National Academy of Sciences - PNAS (27.08.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (27.08.2024)
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Journal Article
Variable Response to BCL2 Inhibition in MDS Is Enhanced across MDS Subtypes with Synergistic Combination of BCL2+MCL1 Inhibition
Fischer, Melissa A., Arrate, Maria, Childress, Merrida A, Smith, Brianna N, Song, Yuanbin, Gbyli, Rana, Stricker, Thomas, Halene, Stephanie, Savona, Michael R.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Pevonedistat, a Nedd-8 Activating Enzyme Inhibitor, Upregulates NOXA to Increase Effectiveness of Azacitidine and Venetoclax in Preclinical Models of Acute Myelogenous Leukemia
Smith, Brianna N, Cojocari, Dan, Purkal, Julie J, Arrate, Maria, Ramsey, Haley E., Leverson, Joel D., Boghaert, Erwin, Phillips, Darren C., Savona, Michael R.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
Howard, Gregory Caleb, Wang, Jing, Rose, Kristie L, Jones, Camden, Patel, Purvi, Tsui, Tina, Florian, Andrea C, Vlach, Logan, Lorey, Shelly L, Grieb, Brian C, Smith, Brianna N, Slota, Macey J, Reynolds, Elizabeth M, Goswami, Soumita, Savona, Michael R, Mason, Frank M, Lee, Taekyu, Fesik, Stephen, Liu, Qi, Tansey, William P
Published in eLife (29.04.2024)
Published in eLife (29.04.2024)
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Journal Article
The delta isoform of PI3K predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib
Villaume, Matthew T., Arrate, M. Pia, Ramsey, Haley E., Sunthankar, Kathryn I., Jenkins, Matthew T., Moyo, Tamara K., Smith, Brianna N., Fischer, Melissa A., Childress, Merrida A., Gorska, Agnieszka E., Ferrell, P. Brent, Savona, Michael R.
Published in Experimental hematology (19.02.2021)
Published in Experimental hematology (19.02.2021)
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Geno-Clinical Model for the Diagnosis of Bone Marrow Myeloid Neoplasms
Hilton, Cameron Beau, Meggendorfer, Manja, Sekeres, Mikkael A., Shreve, Jacob, Radakovich, Nathan, Rouphail, Yazan, Walter, Wencke, Hutter, Stephan, Padron, Eric, Savona, Michael R., Gerds, Aaron T., Mukherjee, Sudipto, Smith, Brianna N, Nagata, Yasunobu, Hirsch, Cassandra M., Komrokji, Rami S., Jha, Babal K., Haferlach, Claudia, Maciejewski, Jaroslaw P., Haferlach, Torsten, Nazha, Aziz
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
Howard, Gregory C, Wang, Jing, Rose, Kristie Lindsey, Jones, Camden, Patel, Purvi, Tsui, Tina, Florian, Andrea C, Vlach, Logan, Lorey, Shelly L, Grieb, Brian C, Smith, Brianna N, Slota, Macey J, Reynolds, Elizabeth M, Goswami, Soumita, Savona, Michael R, Mason, Frank M, Lee, Taekyu, Fesik, Stephen W, Liu, Qi, Tansey, William P
Published in bioRxiv : the preprint server for biology (10.01.2024)
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Published in bioRxiv : the preprint server for biology (10.01.2024)
Journal Article
MCL1 dependence across MDS subtypes and dual inhibition of MCL1 and BCL2 in MISTRG6 mice
Fischer, Melissa A, Song, Yuanbin, Rana Gbyli, Arrate, Maria P, Villaume, Matthew T, Childress, Merrida A, Smith, Brianna N, Stricker, Thomas P, Halene, Stephanie, Savona, Michael R
Published in bioRxiv (06.06.2020)
Published in bioRxiv (06.06.2020)
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