Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
Shaw, Alice T, Friboulet, Luc, Leshchiner, Ignaty, Gainor, Justin F, Bergqvist, Simon, Brooun, Alexei, Burke, Benjamin J, Deng, Ya-Li, Liu, Wei, Dardaei, Leila, Frias, Rosa L, Schultz, Kate R, Logan, Jennifer, James, Leonard P, Smeal, Tod, Timofeevski, Sergei, Katayama, Ryohei, Iafrate, A. John, Le, Long, McTigue, Michele, Getz, Gad, Johnson, Ted W, Engelman, Jeffrey A
Published in The New England journal of medicine (07.01.2016)
Published in The New England journal of medicine (07.01.2016)
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PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models
Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod
Published in Cancer cell (13.07.2015)
Published in Cancer cell (13.07.2015)
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PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
Zou, Helen Y., Li, Qiuhua, Engstrom, Lars D., West, Melissa, Appleman, Vicky, Wong, Katy A., McTigue, Michele, Deng, Ya-Li, Liu, Wei, Brooun, Alexei, Timofeevski, Sergei, McDonnell, Scott R. P., Jiang, Ping, Falk, Matthew D., Lappin, Patrick B., Affolter, Timothy, Nichols, Tim, Hu, Wenyue, Lam, Justine, Johnson, Ted W., Smeal, Tod, Charest, Al, Fantin, Valeria R.
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2015)
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The ALK/ROS1 Inhibitor PF-06463922 Overcomes Primary Resistance to Crizotinib in ALK-Driven Neuroblastoma
Infarinato, Nicole R, Park, Jin H, Krytska, Kateryna, Ryles, Hannah T, Sano, Renata, Szigety, Katherine M, Li, Yimei, Zou, Helen Y, Lee, Nathan V, Smeal, Tod, Lemmon, Mark A, Mossé, Yael P
Published in Cancer discovery (01.01.2016)
Published in Cancer discovery (01.01.2016)
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Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
Murray, Brion W, Guo, Chuangxing, Piraino, Joseph, Westwick, John K, Zhang, Cathy, Lamerdin, Jane, Dagostino, Eleanor, Knighton, Daniel, Loi, Cho-Ming, Zager, Michael, Kraynov, Eugenia, Popoff, Ian, Christensen, James G, Martinez, Ricardo, Kephart, Susan E, Marakovits, Joseph, Karlicek, Shannon, Bergqvist, Simon, Smeal, Tod
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2010)
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Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)
Zhang, Yanyan, Saavedra, Erika, Tang, Ruoping, Gu, Yin, Lappin, Patrick, Trajkovic, Dusko, Liu, Shu-Hui, Smeal, Tod, Fantin, Valeria, De Botton, Stephane, Legrand, Ollivier, Delhommeau, Francois, Pernasetti, Flavia, Louache, Fawzia
Published in Scientific reports (04.08.2017)
Published in Scientific reports (04.08.2017)
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Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies
Bagrodia, Shubha, Smeal, Tod, Abraham, Robert T.
Published in Pigment cell and melanoma research (01.11.2012)
Published in Pigment cell and melanoma research (01.11.2012)
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Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of anaplastic lymphoma kinase and c-Ros oncogene 1
Yamazaki, Shinji, Lam, Justine L, Zou, Helen Y, Wang, Hui, Smeal, Tod, Vicini, Paolo
Published in The Journal of pharmacology and experimental therapeutics (01.10.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2014)
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Mechanistic understanding of translational pharmacokinetic-pharmacodynamic relationships in nonclinical tumor models: a case study of orally available novel inhibitors of anaplastic lymphoma kinase
Yamazaki, Shinji, Lam, Justine L, Zou, Helen Y, Wang, Hui, Smeal, Tod, Vicini, Paolo
Published in Drug metabolism and disposition (01.01.2015)
Published in Drug metabolism and disposition (01.01.2015)
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Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia
Kashyap, Manoj K, Amaya-Chanaga, Carlos I, Kumar, Deepak, Simmons, Brett, Huser, Nanni, Gu, Yin, Hallin, Max, Lindquist, Kevin, Yafawi, Rolla, Choi, Michael Y, Amine, Ale-Ali, Rassenti, Laura Z, Zhang, Cathy, Liu, Shu-Hui, Smeal, Tod, Fantin, Valeria R, Kipps, Thomas J, Pernasetti, Flavia, Castro, Januario E
Published in Journal of hematology and oncology (19.05.2017)
Published in Journal of hematology and oncology (19.05.2017)
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Sensitivity of selected human tumor models to PF-04217903, a novel selective c-Met kinase inhibitor
Zou, Helen Y, Li, Qiuhua, Lee, Joseph H, Arango, Maria E, Burgess, Kristina, Qiu, Ming, Engstrom, Lars D, Yamazaki, Shinji, Parker, Max, Timofeevski, Sergei, Cui, Jingrong Jean, McTigue, Michele, Los, Gerrit, Bender, Steven L, Smeal, Tod, Christensen, James G
Published in Molecular cancer therapeutics (01.04.2012)
Published in Molecular cancer therapeutics (01.04.2012)
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Discovery of Pyrroloaminopyrazoles as Novel PAK Inhibitors
Guo, Chuangxing, McAlpine, Indrawan, Zhang, Junhu, Knighton, Daniel D, Kephart, Susan, Johnson, M. Catherine, Li, Haitao, Bouzida, Djamal, Yang, Anle, Dong, Liming, Marakovits, Joseph, Tikhe, Jayashree, Richardson, Paul, Guo, Lisa C, Kania, Robert, Edwards, Martin P, Kraynov, Eugenia, Christensen, James, Piraino, Joseph, Lee, Joseph, Dagostino, Eleanor, Del-Carmen, Christine, Deng, Ya-Li, Smeal, Tod, Murray, Brion W
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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PAK4 mediates morphological changes through the regulation of GEF-H1
Callow, Marinella G, Zozulya, Sergey, Gishizky, Mikhail L, Jallal, Bahija, Smeal, Tod
Published in Journal of cell science (01.05.2005)
Published in Journal of cell science (01.05.2005)
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Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines
Callow, Marinella G., Clairvoyant, Felix, Zhu, Shirley, Schryver, Brian, Whyte, David B., Bischoff, James R., Jallal, Bahija, Smeal, Tod
Published in The Journal of biological chemistry (04.01.2002)
Published in The Journal of biological chemistry (04.01.2002)
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A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies
Liu, Shu-Hui, Gu, Yin, Pascual, Bernadette, Yan, Zhengming, Hallin, Max, Zhang, Cathy, Fan, Conglin, Wang, Wenlian, Lam, Justine, Spilker, Mary E., Yafawi, Rolla, Blasi, Eileen, Simmons, Brett, Huser, Nanni, Ho, Wei-Hsien, Lindquist, Kevin, Tran, Thomas-Toan, Kudaravalli, Jyothirmayee, Ma, Jing-Tyan, Jimenez, Gretchen, Barman, Ishita, Brown, Colleen, Chin, Sherman Michael, Costa, Maria J., Shelton, David, Smeal, Tod, Fantin, Valeria R., Pernasetti, Flavia
Published in Blood advances (27.06.2017)
Published in Blood advances (27.06.2017)
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The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis
Yin, Min-Jean, Shao, Lihua, Voehringer, David, Smeal, Tod, Jallal, Bahija
Published in The Journal of biological chemistry (26.12.2003)
Published in The Journal of biological chemistry (26.12.2003)
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Control of transcription factors by signal transduction pathways: the beginning of the end
Karin, Michael, Smeal, Tod
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.10.1992)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.10.1992)
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