Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie A, Waddell, Ian D, Ogilvie, Donald J
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
Get full text
Journal Article
Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II
Raoof, Ali, Depledge, Paul, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hopkins, Gemma V, Jordan, Allan M, Maguire, Laura A, McGonagle, Alison E, Mould, Daniel P, Rushbrooke, Mathew, Small, Helen F, Smith, Kate M, Thomson, Graeme J, Turlais, Fabrice, Waddell, Ian D, Waszkowycz, Bohdan, Watson, Amanda J, Ogilvie, Donald J
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
Get full text
Journal Article
Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1
Mould, Daniel P., Bremberg, Ulf, Jordan, Allan M., Geitmann, Matthis, Maiques-Diaz, Alba, McGonagle, Alison E., Small, Helen F., Somervaille, Tim C.P., Ogilvie, Donald
Published in Bioorganic & medicinal chemistry letters (15.07.2017)
Published in Bioorganic & medicinal chemistry letters (15.07.2017)
Get full text
Journal Article
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity
Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Published in European journal of medicinal chemistry (13.04.2016)
Published in European journal of medicinal chemistry (13.04.2016)
Get full text
Journal Article
Novel Steroid Inhibitors of Glucose 6-Phosphate Dehydrogenase
Hamilton, Niall M, Dawson, Martin, Fairweather, Emma E, Hamilton, Nicola S, Hitchin, James R, James, Dominic I, Jones, Stuart D, Jordan, Allan M, Lyons, Amanda J, Small, Helen F, Thomson, Graeme J, Waddell, Ian D, Ogilvie, Donald J
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
Get full text
Journal Article
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure
Acton, Ben, Small, Helen F., Smith, Kate M., McGonagle, Alison, Stowell, Alexandra I.J., James, Dominic I., Hamilton, Niall M., Hamilton, Nicola, Hitchin, James R., Hutton, Colin P., Waddell, Ian D., Ogilvie, Donald J., Jordan, Allan M.
Published in Bioorganic & medicinal chemistry letters (15.02.2019)
Published in Bioorganic & medicinal chemistry letters (15.02.2019)
Get full text
Journal Article
Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position
Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Get full text
Journal Article
Elevated plasma 2‐hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment
Wiseman, Daniel H., Small, Helen F., Wilks, Deepti P., Waddell, Ian D., Dennis, Michael W., Ogilvie, Donald J., Somervaille, Tim C. P.
Published in British journal of haematology (01.07.2014)
Published in British journal of haematology (01.07.2014)
Get full text
Journal Article
Elevated plasma 2‐hydroxyglutarate in acute myeloid leukaemia: association with the IDH 1 SNP rs11554137 and severe renal impairment
Wiseman, Daniel H., Small, Helen F., Wilks, Deepti P., Waddell, Ian D., Dennis, Michael W., Ogilvie, Donald J., Somervaille, Tim C. P.
Published in British journal of haematology (01.07.2014)
Published in British journal of haematology (01.07.2014)
Get full text
Journal Article