Development of Potent Mcl‑1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen
Hekking, Koen F. W., Maroto, Sergio, van Kekem, Kees, Haasjes, Frank S., Slootweg, Jack C., Oude Alink, Patrick G. B., Dirks, Ron, Sardana, Malvika, Bolster, Marjon G., Kuijpers, Brian, Smith, Dennis, Doodeman, Robin, Scheepstra, Marcel, Zech, Birgit, Mulvihill, Mark, Renzetti, Louis M., Babiss, Lee, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Guié, Marie-Aude, Sigel, Eric, Habeshian, Sevan, Hupp, Christopher D., Liu, Julie, Thomson, Heather A., Zhang, Ying, Keefe, Anthony D., Müller, Gerhard, Gremmen, Stijn
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
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Main Phenolic Compounds of the Melanin Biosynthesis Pathway in Bruising-Tolerant and Bruising-Sensitive Button Mushroom (Agaricus bisporus) Strains
Weijn, Amrah, van den Berg-Somhorst, Dianne B. P. M, Slootweg, Jack C, Vincken, Jean-Paul, Gruppen, Harry, Wichers, Harry J, Mes, Jurriaan J
Published in Journal of agricultural and food chemistry (28.08.2013)
Published in Journal of agricultural and food chemistry (28.08.2013)
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Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp(3) versus sp(2) hybridization of the alpha-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity
Slootweg, Jack C., van Herwerden, Eric. F., van Doremalen, Mark. F. M., Breukink, Eefjan, Liskamp, Rob M. J., Rijkers, Dirk T. S.
Published in Organic & biomolecular chemistry (07.06.2015)
Published in Organic & biomolecular chemistry (07.06.2015)
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Journal Article
Synthesis, Antimicrobial Activity, and Membrane Permeabilizing Properties of C‑Terminally Modified Nisin Conjugates Accessed by CuAAC
Slootweg, Jack C, van der Wal, Steffen, Quarles van Ufford, H. C, Breukink, Eefjan, Liskamp, Rob M. J, Rijkers, Dirk T. S
Published in Bioconjugate chemistry (18.12.2013)
Published in Bioconjugate chemistry (18.12.2013)
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Journal Article
Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment
Slootweg, Jack C., Peters, Nienke, Quarles van Ufford, H. (Linda) C., Breukink, Eefjan, Liskamp, Rob M.J., Rijkers, Dirk T.S.
Published in Bioorganic & medicinal chemistry (01.10.2014)
Published in Bioorganic & medicinal chemistry (01.10.2014)
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Journal Article
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative
Slootweg, Jack C., van Schaik, Timo B., Quarles van Ufford, H. (Linda) C., Breukink, Eefjan, Liskamp, Rob M.J., Rijkers, Dirk T.S.
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Journal Article
Synthesis and structural characterization of the individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimicElectronic supplementary information (ESI) available: Experimental details of the membrane permeabilization studies as well as the bacterial growth inhibition assay; copies of HPLC and LCMS data of 2; 1H, TOCSY, ROESY and HSQC NMR spectra of 2a-d; 1H, 1H-COSY and 13C NMR spectra of 7, 9-11; ESI-MS and HPLC data of peptides 1, 2a-d, 3-5, 13. See DOI: 10.1039/c3ob41359d
Slootweg, Jack C, Kemmink, Johan, Liskamp, Rob M. J, Rijkers, Dirk T. S
Year of Publication 16.10.2013
Year of Publication 16.10.2013
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Journal Article
Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp3versus sp2 hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinityElectronic supplementary information (ESI) available: Copies of 1H and 13C NMR spectra, ESI-MS spectra, HPLC chromatograms and LC-MS data. See DOI: 10.1039/c5ob00336a
Slootweg, Jack C, van Herwerden, Eric. F, van Doremalen, Mark. F. M, Breukink, Eefjan, Liskamp, Rob M. J, Rijkers, Dirk T. S
Year of Publication 19.05.2015
Year of Publication 19.05.2015
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Journal Article
Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp 3 versus sp 2 hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity
Slootweg, Jack C., van Herwerden, Eric. F., van Doremalen, Mark. F. M., Breukink, Eefjan, Liskamp, Rob M. J., Rijkers, Dirk T. S.
Published in Organic & biomolecular chemistry (2015)
Published in Organic & biomolecular chemistry (2015)
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