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How May GIP Enhance the Therapeutic Efficacy of GLP-1?
Samms, Ricardo J., Coghlan, Matthew P., Sloop, Kyle W.
Published in Trends in endocrinology and metabolism (01.06.2020)
Published in Trends in endocrinology and metabolism (01.06.2020)
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Orforglipron (LY3502970), a novel, oral non‐peptide glucagon‐like peptide‐1 receptor agonist: A Phase 1b, multicentre, blinded, placebo‐controlled, randomized, multiple‐ascending‐dose study in people with type 2 diabetes
Pratt, Edward, Ma, Xiaosu, Liu, Rong, Robins, Deborah, Coskun, Tamer, Sloop, Kyle W., Haupt, Axel, Benson, Charles
Published in Diabetes, obesity & metabolism (01.09.2023)
Published in Diabetes, obesity & metabolism (01.09.2023)
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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept
Coskun, Tamer, Urva, Shweta, Roell, William C., Qu, Hongchang, Loghin, Corina, Moyers, Julie S., O’Farrell, Libbey S., Briere, Daniel A., Sloop, Kyle W., Thomas, Melissa K., Pirro, Valentina, Wainscott, David B., Willard, Francis S., Abernathy, Matthew, Morford, LaRonda, Du, Yu, Benson, Charles, Gimeno, Ruth E., Haupt, Axel, Milicevic, Zvonko
Published in Cell metabolism (06.09.2022)
Published in Cell metabolism (06.09.2022)
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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
Coskun, Tamer, Sloop, Kyle W., Loghin, Corina, Alsina-Fernandez, Jorge, Urva, Shweta, Bokvist, Krister B., Cui, Xuewei, Briere, Daniel A., Cabrera, Over, Roell, William C., Kuchibhotla, Uma, Moyers, Julie S., Benson, Charles T., Gimeno, Ruth E., D'Alessio, David A., Haupt, Axel
Published in Molecular metabolism (Germany) (01.12.2018)
Published in Molecular metabolism (Germany) (01.12.2018)
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Activation of the GLP-1 receptor by a non-peptidic agonist
Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Nature (London) (16.01.2020)
Published in Nature (London) (16.01.2020)
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GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior
Samms, Ricardo J., Cosgrove, Richard, Snider, Brandy M., Furber, Ellen C., Droz, Brian A., Briere, Daniel A., Dunbar, James, Dogra, Mridula, Alsina-Fernandez, Jorge, Borner, Tito, De Jonghe, Bart C., Hayes, Matthew R., Coskun, Tamer, Sloop, Kyle W., Emmerson, Paul J., Ai, Minrong
Published in Diabetes (New York, N.Y.) (01.07.2022)
Published in Diabetes (New York, N.Y.) (01.07.2022)
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The current state of GPCR‐based drug discovery to treat metabolic disease
Sloop, Kyle W, Emmerson, Paul J, Statnick, Michael A, Willard, Francis S
Published in British journal of pharmacology (01.11.2018)
Published in British journal of pharmacology (01.11.2018)
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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
Willard, Francis S., Douros, Jonathan D., Gabe, Maria B.N., Showalter, Aaron D., Wainscott, David B., Suter, Todd M., Capozzi, Megan E., van der Velden, Wijnand J.C., Stutsman, Cynthia, Cardona, Guemalli R., Urva, Shweta, Emmerson, Paul J., Holst, Jens J., D’Alessio, David A., Coghlan, Matthew P., Rosenkilde, Mette M., Campbell, Jonathan E., Sloop, Kyle W.
Published in JCI insight (03.09.2020)
Published in JCI insight (03.09.2020)
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GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders
Samms, Ricardo J., Sloop, Kyle W., Gribble, Fiona M., Reimann, Frank, Adriaenssens, Alice E.
Published in Diabetes (New York, N.Y.) (01.09.2021)
Published in Diabetes (New York, N.Y.) (01.09.2021)
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The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition
Capozzi, Megan E., Coch, Reilly W., Koech, Jepchumba, Astapova, Inna I., Wait, Jacob B., Encisco, Sara E., Douros, Jonathan D., El, Kimberly, Finan, Brian, Sloop, Kyle W., Herman, Mark A., D’Alessio, David A., Campbell, Jonathan E.
Published in Diabetes (New York, N.Y.) (01.05.2020)
Published in Diabetes (New York, N.Y.) (01.05.2020)
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The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction
Prentice, Kacey J., Luu, Lemieux, Allister, Emma M., Liu, Ying, Jun, Lucy S., Sloop, Kyle W., Hardy, Alexandre B., Wei, Li, Jia, Weiping, Fantus, I. George, Sweet, Douglas H., Sweeney, Gary, Retnakaran, Ravi, Dai, Feihan F., Wheeler, Michael B.
Published in Cell metabolism (01.04.2014)
Published in Cell metabolism (01.04.2014)
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Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells
Gray, Sarah M., Xin, Yurong, Ross, Elizabeth C., Chazotte, Bryanna M., Capozzi, Megan E., El, Kimberley, Svendsen, Berit, Ravn, Peter, Sloop, Kyle W., Tong, Jenny, Gromada, Jesper, Campbell, Jonathan E., D'Alessio, David A.
Published in The Journal of biological chemistry (14.08.2020)
Published in The Journal of biological chemistry (14.08.2020)
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Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue
Samms, Ricardo J., Zhang, GuoFang, He, Wentao, Ilkayeva, Olga, Droz, Brian A., Bauer, Steven M., Stutsman, Cynthia, Pirro, Valentina, Collins, Kyla A., Furber, Ellen C., Coskun, Tamer, Sloop, Kyle W., Brozinick, Joseph T., Newgard, Christopher B.
Published in Molecular metabolism (Germany) (01.10.2022)
Published in Molecular metabolism (Germany) (01.10.2022)
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Is Glucagon Receptor Activation the Thermogenic Solution for Treating Obesity?
Conceição-Furber, Ellen, Coskun, Tamer, Sloop, Kyle W., Samms, Ricardo J.
Published in Frontiers in endocrinology (Lausanne) (25.04.2022)
Published in Frontiers in endocrinology (Lausanne) (25.04.2022)
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Differential Activation and Modulation of the Glucagon-Like Peptide-1 Receptor by Small Molecule Ligands
Wootten, Denise, Savage, Emilia E., Willard, Francis S., Bueno, Ana B., Sloop, Kyle W., Christopoulos, Arthur, Sexton, Patrick M.
Published in Molecular pharmacology (01.04.2013)
Published in Molecular pharmacology (01.04.2013)
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Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production
Jun, Lucy S., Millican, Rohn L., Hawkins, Eric D., Konkol, Debra L., Showalter, Aaron D., Christe, Michael E., Michael, M. Dodson, Sloop, Kyle W.
Published in Diabetes (New York, N.Y.) (01.03.2015)
Published in Diabetes (New York, N.Y.) (01.03.2015)
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Characterization of LY3324954 a long-acting glucagon-receptor agonist
Roell, William, Coskun, Tamer, Kim, Teayoun, O’Farrell, Libbey, Martin, Jennifer A., Nason, Shelly, Hernandez-Alamillo, Jasmin, Dhantu, Saidharshana, Drucker, Daniel J., Sloop, Kyle W., Steele, James P., Alsina-Fernandez, Jorge, Habegger, Kirk M.
Published in Molecular metabolism (Germany) (01.01.2025)
Published in Molecular metabolism (Germany) (01.01.2025)
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Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets
Sloop, Kyle W., Willard, Francis S., Brenner, Martin B., Ficorilli, James, Valasek, Kathleen, Showalter, Aaron D., Farb, Thomas B., Cao, Julia X.C., Cox, Amy L., Michael, M. Dodson, Gutierrez Sanfeliciano, Sonia Maria, Tebbe, Mark J., Coghlan, Michael J.
Published in Diabetes (New York, N.Y.) (01.12.2010)
Published in Diabetes (New York, N.Y.) (01.12.2010)
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GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells
Saikia, Mridusmita, Holter, Marlena M., Donahue, Leanne R., Lee, Isaac S., Zheng, Qiaonan C., Wise, Journey L., Todero, Jenna E., Phuong, Daryl J., Garibay, Darline, Coch, Reilly, Sloop, Kyle W., Garcia-Ocana, Adolfo, Danko, Charles G., Cummings, Bethany P.
Published in JCI insight (08.02.2021)
Published in JCI insight (08.02.2021)
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β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice
Garibay, Darline, Lou, Jon, Lee, Seon A., Zaborska, Karolina E., Weissman, Margot H., Sloma, Erica, Donahue, Leanne, Miller, Andrew D., White, Andrew C., Michael, M. Dodson, Sloop, Kyle W., Cummings, Bethany P.
Published in Cell reports (Cambridge) (24.04.2018)
Published in Cell reports (Cambridge) (24.04.2018)
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