Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial
Wang, Michael, Rule, Simon, Zinzani, Pier Luigi, Goy, Andre, Casasnovas, Olivier, Smith, Stephen D, Damaj, Gandhi, Doorduijn, Jeanette, Lamy, Thierry, Morschhauser, Franck, Panizo, Carlos, Shah, Bijal, Davies, Andrew, Eek, Richard, Dupuis, Jehan, Jacobsen, Eric, Kater, Arnon P, Le Gouill, Steven, Oberic, Lucie, Robak, Taduesz, Covey, Todd, Dua, Richa, Hamdy, Ahmed, Huang, Xin, Izumi, Raquel, Patel, Priti, Rothbaum, Wayne, Slatter, J Greg, Jurczak, Wojciech
Published in The Lancet (British edition) (17.02.2018)
Published in The Lancet (British edition) (17.02.2018)
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Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans
Podoll, Terry, Pearson, Paul G, Evarts, Jerry, Ingallinera, Tim, Bibikova, Elena, Sun, Hao, Gohdes, Mark, Cardinal, Kristen, Sanghvi, Mitesh, Slatter, J Greg
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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Phase 1 Concentration‐QTc and Cardiac Safety Analysis of the MDM2 Antagonist KRT‐232 in Patients With Advanced Solid Tumors, Multiple Myeloma, or Acute Myeloid Leukemia
Taylor, Adekemi, Lee, Dana, Allard, Martine, Poland, Bill, Greg Slatter, J.
Published in Clinical pharmacology in drug development (01.08.2021)
Published in Clinical pharmacology in drug development (01.08.2021)
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Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
Yang, Xia, Zhang, Bin, Molony, Cliona, Chudin, Eugene, Hao, Ke, Zhu, Jun, Gaedigk, Andrea, Suver, Christine, Zhong, Hua, Leeder, J Steven, Guengerich, F Peter, Strom, Stephen C, Schuetz, Erin, Rushmore, Thomas H, Ulrich, Roger G, Slatter, J Greg, Schadt, Eric E, Kasarskis, Andrew, Lum, Pek Yee
Published in Genome research (01.08.2010)
Published in Genome research (01.08.2010)
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Evaluation of the Drug–Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP‐5862, Using a Physiologically‐Based Pharmacokinetic Modeling Approach
Zhou, Diansong, Podoll, Terry, Xu, Yan, Moorthy, Ganesh, Vishwanathan, Karthick, Ware, Joseph, Slatter, J. Greg, Al‐Huniti, Nidal
Published in CPT: pharmacometrics and systems pharmacology (01.07.2019)
Published in CPT: pharmacometrics and systems pharmacology (01.07.2019)
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Evaluation of Evolocumab (AMG 145), a Fully Human Anti‐PCSK9 IgG2 Monoclonal Antibody, in Subjects With Hepatic Impairment
Gibbs, John P., Slatter, J. Greg, Egbuna, Ogo, Geller, Michelle, Hamilton, Lisa, Dias, Clapton S., Xu, Ren Y., Johnson, Jessica, Wasserman, Scott M., Emery, Maurice G.
Published in Journal of clinical pharmacology (01.04.2017)
Published in Journal of clinical pharmacology (01.04.2017)
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PB2205: A MECHANISTIC ABSORPTION AND PHARMACOKINETIC MODEL OF COVALENT BTK INHIBITOR TL‐895: INFLUENCE OF FOOD AND ACID REDUCING AGENTS
Macwan, Joyce, Fraczkiewicz, Grace, Podoll, Terry, Allard, Martine, Krejsa, Cecile, Slatter, Greg
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Murine collagen antibody induced arthritis (CAIA) and primary mouse hepatocyte culture as models to study cytochrome P450 suppression
Dickmann, Leslie J., McBride, Helen J., Patel, Sonal K., Miner, Kent, Wienkers, Larry C., Slatter, J. Greg
Published in Biochemical pharmacology (15.06.2012)
Published in Biochemical pharmacology (15.06.2012)
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PROFILING THE HEPATIC EFFECTS OF FLUTAMIDE IN RATS: A MICROARRAY COMPARISON WITH CLASSICAL ARYL HYDROCARBON RECEPTOR LIGANDS AND ATYPICAL CYP1A INDUCERS
COE, Kevin J, NELSON, Sidney D, ULRICH, Roger G, YUDONG HE, XUDONG DAI, CHENG, Olivia, CAGUYONG, Michelle, ROBERTS, Chris J, GREG SLATTER, J
Published in Drug metabolism and disposition (01.07.2006)
Published in Drug metabolism and disposition (01.07.2006)
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Intestinal and hepatic first-pass extraction of the 11β-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters
Gao, Qiuxia, Kimura, Robert E., Zhang, Xiping, Nam, Joon, Amore, Benny M., Hickman, Dean, Slatter, J. Greg, Emery, Maurice G.
Published in Xenobiotica (01.03.2014)
Published in Xenobiotica (01.03.2014)
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In Vitro Metabolic Activation of Lumiracoxib in Rat and Human Liver Preparations
Li, Ying, Slatter, J Greg, Zhang, Zhoupeng, Li, Yan, Doss, George A, Braun, Matthew P, Stearns, Ralph A, Dean, Dennis C, Baillie, Thomas A, Tang, Wei
Published in Drug metabolism and disposition (01.02.2008)
Published in Drug metabolism and disposition (01.02.2008)
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PB2200: FOOD AND ACID REDUCING AGENT EFFECTS ON PHARMACOKINETICS (PK) AND PHARMACODYNAMICS (PD) OF THE COVALENT BRUTON TYROSINE KINASE INHIBITOR (BTKI) TL-895 IN HEALTHY SUBJECTS
Allard, Martine, Krejsa, Cecile, Williams, Isaiah, Podoll, Terry, Steinmann, Kim, Slatter, Greg
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Journal Article
Identification and Characterization of ACP-5862, the Major Circulating Active Metabolite of Acalabrutinib: Both Are Potent and Selective Covalent Bruton Tyrosine Kinase Inhibitors
Podoll, Terry, Pearson, Paul G, Kaptein, Allard, Evarts, Jerry, de Bruin, Gerjan, Emmelot-van Hoek, Maaike, de Jong, Anouk, van Lith, Bart, Sun, Hao, Byard, Stephen, Fretland, Adrian, Hoogenboom, Niels, Barf, Tjeerd, Slatter, J Greg
Published in The Journal of pharmacology and experimental therapeutics (01.01.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2023)
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P170 - Microtracer bioavailability, biotransformation mechanisms, and excretion of the covalent BTK inhibitor acalabrutinib in humans
Podoll, Terry, Pearson, Paul G., Evarts, Jerry, Ingallinera, Tim, Bibikova, Elena, Sun, Hao, Gohdes, Mark, Byard, Stephen, Cardinal, Kristen, Sanghvi, Mitesh, Slatter, J. Greg
Published in Drug metabolism and pharmacokinetics (2020)
Published in Drug metabolism and pharmacokinetics (2020)
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Population Pharmacokinetics of the BTK Inhibitor Acalabrutinib and its Active Metabolite in Healthy Volunteers and Patients with B-Cell Malignancies
Edlund, Helena, Lee, Sun Ku, Andrew, Marilee A., Slatter, J. Greg, Aksenov, Sergey, Al-Huniti, Nidal
Published in Clinical pharmacokinetics (01.05.2019)
Published in Clinical pharmacokinetics (01.05.2019)
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