Brønsted Acid-Catalyzed Highly Stereoselective Arene-Ynamide Cyclizations. A Novel Keteniminium Pictet−Spengler Cyclization in Total Syntheses of (±)-Desbromoarborescidines A and C
Zhang, Yanshi, Hsung, Richard P, Zhang, Xuejun, Huang, Jian, Slafer, Brian W, Davis, Allison
Published in Organic letters (17.03.2005)
Published in Organic letters (17.03.2005)
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Journal Article
Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics
Pauli, Ivani, Rezende, Jr, Celso de O, Slafer, Brian W, Dessoy, Marco A, de Souza, Mariana L, Ferreira, Leonardo L G, Adjanohun, Abraham L M, Ferreira, Rafaela S, Magalhães, Luma G, Krogh, Renata, Michelan-Duarte, Simone, Del Pintor, Ricardo Vaz, da Silva, Fernando B R, Cruz, Fabio C, Dias, Luiz C, Andricopulo, Adriano D
Published in Frontiers in pharmacology (05.01.2022)
Published in Frontiers in pharmacology (05.01.2022)
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Synthesis and Anti-Trypanosoma cruzi Activity of 3‑Cyanopyridine Derivatives
Slafer, Brian W., Dessoy, Marco A., de Oliveira, Ramon G., Mollo, Maria C., Lee, Eun, Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G., Krogh, Renata, Andricopulo, Adriano D., Cruz, Luiza R., Mowbray, Charles E., Kratz, Jadel M., Dias, Luiz C.
Published in ACS omega (21.05.2024)
Published in ACS omega (21.05.2024)
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Journal Article
Fully Substituted Carbon Centers by Diastereoselective Spirocyclization: Stereoselective Synthesis of (+)-Lepadiformine C
Perry, Matthew A, Morin, Matthew D, Slafer, Brian W, Wolckenhauer, Scott A, Rychnovsky, Scott D
Published in Journal of the American Chemical Society (21.07.2010)
Published in Journal of the American Chemical Society (21.07.2010)
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Journal Article
Asymmetric Carbon−Carbon Bond Formations in Conjugate Additions of Lithiated N-Boc Allylic and Benzylic Amines to Nitroalkenes: Enantioselective Synthesis of Substituted Piperidines, Pyrrolidines, and Pyrimidinones
Johnson, Timothy A, Jang, Doo Ok, Slafer, Brian W, Curtis, Michael D, Beak, Peter
Published in Journal of the American Chemical Society (02.10.2002)
Published in Journal of the American Chemical Society (02.10.2002)
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Journal Article
ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment
Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P, Bondke, Alexander, Slafer, Brian W, Kroll, Sebastian H B, Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O, Buluwela, Laki, Fuchter, Matthew J, Barrett, Anthony G M, Coombes, R Charles, Ali, Simak
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
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Journal Article
Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach
de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Ferreira, Rafaela S, Espinoza Chávez, Rocio Marisol, Ferreira, Leonardo L. G, Slafer, Brian W, Magalhães, Luma G, Krogh, Renata, Oliva, Glaucius, Cruz, Fabio Cardoso, Dias, Luiz Carlos, Andricopulo, Adriano D
Published in Journal of chemical information and modeling (24.02.2020)
Published in Journal of chemical information and modeling (24.02.2020)
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Journal Article
Total Synthesis of Lepadiformine Alkaloids using N-Boc α-Amino Nitriles as Trianion Synthons
Perry, Matthew A, Morin, Matthew D, Slafer, Brian W, Rychnovsky, Scott D
Published in Journal of organic chemistry (06.04.2012)
Published in Journal of organic chemistry (06.04.2012)
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Journal Article
Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors
Pauli, Ivani, Ferreira, Leonardo G, de Souza, Mariana L, Oliva, Glaucius, Ferreira, Rafaela S, Dessoy, Marco A, Slafer, Brian W, Dias, Luiz C, Andricopulo, Adriano D
Published in Future medicinal chemistry (01.05.2017)
Published in Future medicinal chemistry (01.05.2017)
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Journal Article
Total Synthesis of (+)-Lepadin F
Li, Gang, Hsung, Richard P, Slafer, Brian W, Sagamanova, Irina K
Published in Organic letters (06.11.2008)
Published in Organic letters (06.11.2008)
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Journal Article
Stereodivergent Approach to Both C2,8a-syn and C2,8a-anti Relative Stereochemical Manifolds in the Lepadin Family via a TiCl4-Promoted Aza-[3+3] Annulation
Li, Gang, Carlson, Lauren J., Sagamanova, Irina K., Slafer, Brian W., Hsung, Richard P., Gilardi, Claudio, Sklenicka, Heather M., Sydorenko, Nadiya
Published in Synthesis (Stuttgart) (01.09.2009)
Published in Synthesis (Stuttgart) (01.09.2009)
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Journal Article
A Stereodivergent Approach for Accessing Both C2,8a-Syn and C2,8a-Anti Relative Stereochemical Manifolds in the Lepadin Family via a TiCL(4)-Promoted Aza-[3 + 3] Annulation
Li, Gang, Carlson, Lauren J, Sagamanova, Irina K, Slafer, Brian W, Hsung, Richard P, Gilardi, Claudio, Sklenicka, Heather M, Sydroenko, Nadiya
Published in Synthesis (Stuttgart) (01.09.2009)
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Published in Synthesis (Stuttgart) (01.09.2009)
Journal Article
ChemInform Abstract: Total Synthesis of (+)-Lepadin F
Li, Gang, Hsung, Richard P., Slafer, Brian W., Sagamanova, Irina K.
Published in ChemInform (24.03.2009)
Published in ChemInform (24.03.2009)
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Journal Article
Broensted Acid Catalyzed Highly Stereoselective Arene-Ynamide Cyclizations. A Novel Keteniminium Pictet-Spengler Cyclization in Total Syntheses of (.+-.)-Desbromoarborescidines A and C
Zhang, Yanshi, Hsung, Richard P., Zhang, Xuejun, Huang, Jian, Slafer, Brian W., Davis, Allison
Published in ChemInform (09.08.2005)
Published in ChemInform (09.08.2005)
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Journal Article
Asymmetric Carbon-Carbon Bond Formations in Conjugate Additions of Lithiated N-Boc Allylic and Benzylic Amines to Nitroalkenes: Enantioselective Synthesis of Substituted Piperidines, Pyrrolidines, and Pyrimidinones
Johnson, Timothy A., Jang, Doo Ok, Slafer, Brian W., Curtis, Michael D., Beak, Peter
Published in ChemInform (11.02.2003)
Published in ChemInform (11.02.2003)
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Journal Article