ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment
Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P, Bondke, Alexander, Slafer, Brian W, Kroll, Sebastian H B, Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O, Buluwela, Laki, Fuchter, Matthew J, Barrett, Anthony G M, Coombes, R Charles, Ali, Simak
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
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Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach
de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Ferreira, Rafaela S, Espinoza Chávez, Rocio Marisol, Ferreira, Leonardo L. G, Slafer, Brian W, Magalhães, Luma G, Krogh, Renata, Oliva, Glaucius, Cruz, Fabio Cardoso, Dias, Luiz Carlos, Andricopulo, Adriano D
Published in Journal of chemical information and modeling (24.02.2020)
Published in Journal of chemical information and modeling (24.02.2020)
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Brønsted Acid-Catalyzed Highly Stereoselective Arene-Ynamide Cyclizations. A Novel Keteniminium Pictet−Spengler Cyclization in Total Syntheses of (±)-Desbromoarborescidines A and C
Zhang, Yanshi, Hsung, Richard P, Zhang, Xuejun, Huang, Jian, Slafer, Brian W, Davis, Allison
Published in Organic letters (17.03.2005)
Published in Organic letters (17.03.2005)
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Total Synthesis of Lepadiformine Alkaloids using N-Boc α-Amino Nitriles as Trianion Synthons
Perry, Matthew A, Morin, Matthew D, Slafer, Brian W, Rychnovsky, Scott D
Published in Journal of organic chemistry (06.04.2012)
Published in Journal of organic chemistry (06.04.2012)
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Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics
Pauli, Ivani, Rezende, Jr, Celso de O, Slafer, Brian W, Dessoy, Marco A, de Souza, Mariana L, Ferreira, Leonardo L G, Adjanohun, Abraham L M, Ferreira, Rafaela S, Magalhães, Luma G, Krogh, Renata, Michelan-Duarte, Simone, Del Pintor, Ricardo Vaz, da Silva, Fernando B R, Cruz, Fabio C, Dias, Luiz C, Andricopulo, Adriano D
Published in Frontiers in pharmacology (05.01.2022)
Published in Frontiers in pharmacology (05.01.2022)
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Synthesis and Anti-Trypanosoma cruzi Activity of 3‑Cyanopyridine Derivatives
Slafer, Brian W., Dessoy, Marco A., de Oliveira, Ramon G., Mollo, Maria C., Lee, Eun, Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G., Krogh, Renata, Andricopulo, Adriano D., Cruz, Luiza R., Mowbray, Charles E., Kratz, Jadel M., Dias, Luiz C.
Published in ACS omega (21.05.2024)
Published in ACS omega (21.05.2024)
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Fully Substituted Carbon Centers by Diastereoselective Spirocyclization: Stereoselective Synthesis of (+)-Lepadiformine C
Perry, Matthew A, Morin, Matthew D, Slafer, Brian W, Wolckenhauer, Scott A, Rychnovsky, Scott D
Published in Journal of the American Chemical Society (21.07.2010)
Published in Journal of the American Chemical Society (21.07.2010)
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Journal Article
Total Synthesis of (+)-Lepadin F
Li, Gang, Hsung, Richard P, Slafer, Brian W, Sagamanova, Irina K
Published in Organic letters (06.11.2008)
Published in Organic letters (06.11.2008)
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A Formal [3 + 3] Cycloaddition Reaction. 5. An Enantioselective Intramolecular Formal Aza-[3 + 3] Cycloaddition Reaction Promoted by Chiral Amine Salts
Gerasyuto, Aleksey I, Hsung, Richard P, Sydorenko, Nadiya, Slafer, Brian
Published in Journal of organic chemistry (27.05.2005)
Published in Journal of organic chemistry (27.05.2005)
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Asymmetric Carbon−Carbon Bond Formations in Conjugate Additions of Lithiated N-Boc Allylic and Benzylic Amines to Nitroalkenes: Enantioselective Synthesis of Substituted Piperidines, Pyrrolidines, and Pyrimidinones
Johnson, Timothy A, Jang, Doo Ok, Slafer, Brian W, Curtis, Michael D, Beak, Peter
Published in Journal of the American Chemical Society (02.10.2002)
Published in Journal of the American Chemical Society (02.10.2002)
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Stereodivergent Approach to Both C2,8a-syn and C2,8a-anti Relative Stereochemical Manifolds in the Lepadin Family via a TiCl4-Promoted Aza-[3+3] Annulation
Li, Gang, Carlson, Lauren J., Sagamanova, Irina K., Slafer, Brian W., Hsung, Richard P., Gilardi, Claudio, Sklenicka, Heather M., Sydorenko, Nadiya
Published in Synthesis (Stuttgart) (01.09.2009)
Published in Synthesis (Stuttgart) (01.09.2009)
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Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells
Ottaviani, Silvia, Delaney, Sean, Patel, Hetal, Periyasamy, Manikandan, Bondke, Alexander, Slafer, Brian, Starkey, Richard, Kroll, Sebastian H.B., Fuchter, Matthew J., Barrett, Anthony G.M., Coombes, R. Charles, Ali, Simak
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Abstract 694: Development of selective and potent CDK7 inhibitors for breast cancer therapy
Patel, Hetal, Ottaviani, Silvia, Periyasamy, Manikandan, Bondke, Alexander, Slafer, Brian, Starkey, Richard, Kroll, Sebastian H.B, Delaney, Sean, Zahoor, Zahida, Fuchter, Matthew J., Barrett, Anthony G.M, Coombes, R. Charles, Ali, Simak
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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A Stereodivergent Approach for Accessing Both C2,8a-Syn and C2,8a-Anti Relative Stereochemical Manifolds in the Lepadin Family via a TiCL(4)-Promoted Aza-[3 + 3] Annulation
Li, Gang, Carlson, Lauren J, Sagamanova, Irina K, Slafer, Brian W, Hsung, Richard P, Gilardi, Claudio, Sklenicka, Heather M, Sydroenko, Nadiya
Published in Synthesis (Stuttgart) (01.09.2009)
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Published in Synthesis (Stuttgart) (01.09.2009)
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