Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
Hirani, Nikhil, MacKinnon, Alison C, Nicol, Lisa, Ford, Paul, Schambye, Hans, Pedersen, Anders, Nilsson, Ulf J, Leffler, Hakon, Sethi, Tariq, Tantawi, Susan, Gravelle, Lise, Slack, Robert J, Mills, Ross, Karmakar, Utsa, Humphries, Duncan, Zetterberg, Fredrik, Keeling, Lucy, Paul, Lyn, Molyneaux, Philip L, Li, Feng, Funston, Wendy, Forrest, Ian A, Simpson, A John, Gibbons, Michael A, Maher, Toby M
Published in The European respiratory journal (01.05.2021)
Published in The European respiratory journal (01.05.2021)
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Discovery and Optimization of the First Highly Effective and Orally Available Galectin‑3 Inhibitors for Treatment of Fibrotic Disease
Zetterberg, Fredrik R., MacKinnon, Alison, Brimert, Thomas, Gravelle, Lise, Johnsson, Richard E., Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Pedersen, Anders, Peterson, Kristoffer, Roper, James A., Schambye, Hans, Slack, Robert J., Tantawi, Susan
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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An αv‐RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities
Hatley, Richard J. D., Macdonald, Simon J. F., Slack, Robert J., Le, Joelle, Ludbrook, Steven B., Lukey, Pauline T.
Published in Angewandte Chemie International Edition (19.03.2018)
Published in Angewandte Chemie International Edition (19.03.2018)
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Discovery of Selective and Orally Available Galectin‑1 Inhibitors
Zetterberg, Fredrik R., Diehl, Carl, Håkansson, Maria, Kahl-Knutson, Barbro, Leffler, Hakon, Nilsson, Ulf J., Peterson, Kristoffer, Roper, James A., Slack, Robert J.
Published in Journal of medicinal chemistry (28.12.2023)
Published in Journal of medicinal chemistry (28.12.2023)
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Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1
Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.
Published in Frontiers in immunology (28.08.2023)
Published in Frontiers in immunology (28.08.2023)
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Discovery of the Selective and Orally Available Galectin‑1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Zetterberg, Fredrik R., Peterson, Kristoffer, Nilsson, Ulf J., Andréasson Dahlgren, Kajsa, Diehl, Carl, Holyer, Ian, Håkansson, Maria, Khabut, Areej, Kahl-Knutson, Barbro, Leffler, Hakon, MacKinnon, Alison C., Roper, James A., Slack, Robert J., Zarrizi, Reihaneh, Pedersen, Anders
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor
Maher, Toby M, Simpson, Juliet K, Porter, Joanna C, Wilson, Frederick J, Chan, Robert, Eames, Rhena, Cui, Yi, Siederer, Sarah, Parry, Simon, Kenny, Julia, Slack, Robert J, Sahota, Jagdeep, Paul, Lyn, Saunders, Peter, Molyneaux, Philip L, Lukey, Pauline T, Rizzo, Gaia, Searle, Graham E, Marshall, Richard P, Saleem, Azeem, Kang'ombe, Arthur R, Fairman, David, Fahy, William A, Vahdati-Bolouri, Mitra
Published in Respiratory research (26.03.2020)
Published in Respiratory research (26.03.2020)
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Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance
Kim, Henry, Kretz, Louis, Ronin, Céline, Starck, Christina, Roper, James A, Kahl-Knutson, Barbro, Peterson, Kristoffer, Leffler, Hakon, Nilsson, Ulf J, Pedersen, Anders, Zetterberg, Fredrik R, Slack, Robert J
Published in International journal of molecular sciences (18.06.2024)
Published in International journal of molecular sciences (18.06.2024)
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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE)
Gaughan, Erin E, Quinn, Tom M, Mills, Andrew, Bruce, Annya M, Antonelli, Jean, MacKinnon, Alison C, Aslanis, Vassilios, Li, Feng, O'Connor, Richard, Boz, Cecilia, Mills, Ross, Emanuel, Philip, Burgess, Matthew, Rinaldi, Giulia, Valanciute, Asta, Mills, Bethany, Scholefield, Emma, Hardisty, Gareth, Findlay, Emily Gwyer, Parker, Richard A, Norrie, John, Dear, James W, Akram, Ahsan R, Koch, Oliver, Templeton, Kate, Dockrell, David H, Walsh, Timothy S, Partridge, Stephen, Humphries, Duncan, Wang-Jairaj, Jie, Slack, Robert J, Schambye, Hans, Phung, De, Gravelle, Lise, Lindmark, Bertil, Shankar-Hari, Manu, Hirani, Nikhil, Sethi, Tariq, Dhaliwal, Kevin
Published in American journal of respiratory and critical care medicine (15.01.2023)
Published in American journal of respiratory and critical care medicine (15.01.2023)
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Characterisation of a novel, high affinity and selective αvβ6 integrin RGD-mimetic radioligand
Hall, Eleanor R., Bibby, Lloyd I., Slack, Robert J.
Published in Biochemical pharmacology (01.10.2016)
Published in Biochemical pharmacology (01.10.2016)
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Pharmacological characterisation of a tool αvβ1 integrin small molecule RGD-mimetic inhibitor
Wilkinson, Alex L., Barrett, John W., Slack, Robert J.
Published in European journal of pharmacology (05.01.2019)
Published in European journal of pharmacology (05.01.2019)
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Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants
Aslanis, Vassilios, Slack, Robert J., MacKinnon, Alison C., McClinton, Catherine, Tantawi, Susan, Gravelle, Lise, Nilsson, Ulf J., Leffler, Hakon, Brooks, Ashley, Khindri, Sanjeev K., Marshall, Richard P., Pedersen, Anders, Schambye, Hans, Zetterberg, Fredrik
Published in Cancer chemotherapy and pharmacology (01.03.2023)
Published in Cancer chemotherapy and pharmacology (01.03.2023)
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Core Modifications of GSK3335103 toward Orally Bioavailable α v β 6 Inhibitors with Improved Synthetic Tractability
Hryczanek, Heather F, Barrett, John, Barrett, Tim N, Burley, Glenn A, Cookson, Rosa E, Hatley, Richard J D, Measom, Nicholas D, Roper, James A, Rowedder, James E, Slack, Robert J, Śmieja, Connor B, Macdonald, Simon J F
Published in Journal of medicinal chemistry (17.10.2024)
Published in Journal of medicinal chemistry (17.10.2024)
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Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis
Calver, Jessica F., Parmar, Nimesh R., Harris, Gemma, Lithgo, Ryan M., Stylianou, Panayiota, Zetterberg, Fredrik R., Gooptu, Bibek, Mackinnon, Alison C., Carr, Stephen B., Borthwick, Lee A., Scott, David J., Stewart, Iain D., Slack, Robert J., Jenkins, R. Gisli, John, Alison E.
Published in The Journal of biological chemistry (01.06.2024)
Published in The Journal of biological chemistry (01.06.2024)
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The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis
Comeglio, Paolo, Guarnieri, Giulia, Filippi, Sandra, Cellai, Ilaria, Acciai, Gabriele, Holyer, Ian, Zetterberg, Fredrik, Leffler, Hakon, Kahl-Knutson, Barbro, Sarchielli, Erica, Morelli, Annamaria, Maggi, Mario, Slack, Robert J, Vignozzi, Linda
Published in Frontiers in pharmacology (31.07.2024)
Published in Frontiers in pharmacology (31.07.2024)
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