Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit
Published in Journal of medicinal chemistry (27.08.1998)
Published in Journal of medicinal chemistry (27.08.1998)
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Synthesis and pharmacological evaluation of sulfone substituted HIV protease inhibitors
Schwartz, Theresa M., Bundy, Gordon L., Strohbach, Joseph W., Thaisrivongs, Suvit, Johnson, Paul D., Skulnick, Harvey I., Tomich, Paul K., Lynn, Janet C., Chong, Kong Teck, Hinshaw, Roger R., Raub, Thomas J., Padbury, Guy E., Toth, Lisa N.
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
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Pyrimidinones. 3. N-Substituted 6-phenylpyrimidinones and pyrimidinediones with diuretic/hypotensive and antiinflammatory activity
Skulnick, Harvey I, Ludens, James H, Wendling, Michael G, Glenn, E. Myles, Rohloff, Norman A, Smith, Robert J, Wierenga, Wendell
Published in Journal of medicinal chemistry (01.08.1986)
Published in Journal of medicinal chemistry (01.08.1986)
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Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors
Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (25.10.1996)
Published in Journal of medicinal chemistry (25.10.1996)
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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors: The Sulfonamide-Substituted Cyclooctylpyranones
Skulnick, Harvey I, Johnson, Paul D, Aristoff, Paul A, Morris, Jeanette K, Lovasz, Kristine D, Howe, W. Jeffrey, Watenpaugh, Keith D, Janakiraman, Musiri N, Anderson, David J, Reischer, Robert J, Schwartz, Theresa M, Banitt, Lee S, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Dolak, Lester A, Seest, Eric P, Schwende, Francis J, Rush, Bob D, Howard, Gina M, Toth, Lisa N, Wilkinson, Karen R, Kakuk, Thomas J, Johnson, Carol W, Cole, Serena L, Zaya, Renee M, Zipp, Gail L, Possert, Peggy L, Dalga, Robert J, Zhong, Wei-Zhu, Williams, Marta G, Romines, Karen R
Published in Journal of medicinal chemistry (28.03.1997)
Published in Journal of medicinal chemistry (28.03.1997)
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Journal Article
Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors
Skulnick, Harvey I, Johnson, Paul D, Howe, W. Jeffrey, Tomich, Paul K, Chong, Kong-Teck, Watenpaugh, Keith D, Janakiraman, Musiri N, Dolak, Lester A, McGrath, James P
Published in Journal of medicinal chemistry (01.12.1995)
Published in Journal of medicinal chemistry (01.12.1995)
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Antitumor activity of pyrimidinones, a class of small-molecule biological response modifiers
Li, L H, Wallace, T L, Wierenga, W, Skulnick, H I, DeKoning, T F
Published in Journal of biological response modifiers (01.02.1987)
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Published in Journal of biological response modifiers (01.02.1987)
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Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones
Skulnick, H I, Johnson, P D, Aristoff, P A, Morris, J K, Lovasz, K D, Howe, W J, Watenpaugh, K D, Janakiraman, M N, Anderson, D J, Reischer, R J, Schwartz, T M, Banitt, L S, Tomich, P K, Lynn, J C, Horng, M M, Chong, K T, Hinshaw, R R, Dolak, L A, Seest, E P, Schwende, F J, Rush, B D, Howard, G M, Toth, L N, Wilkinson, K R, Romines, K R
Published in Journal of medicinal chemistry (28.03.1997)
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Published in Journal of medicinal chemistry (28.03.1997)
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Pyrimidinones. III: N-Substituted 6-phenylpyrimidinones and pyrimidinediones with diuretic/hypotensive and antiinflammatory activity
SKULNICK, H. I, LUDENS, J. H, WENDLING, M. G, GLENN, E. M, ROHLOFF, N. A, SMITH, R. J, WIERENGA, W
Published in Journal of medicinal chemistry (1986)
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Published in Journal of medicinal chemistry (1986)
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