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Liu, Sophia, Yan, Yuetian, Secor, Cody M, Oberholtzer, Zachary R, Skow, Donna J, Sheikh, Mushhood, Moon, Youmi, Fu, Yue, Sandu, Cristinel, Wang, Shunhai, Li, Ning, Nguyen, Jennifer B, Rosconi, Michael P, Pyles, Erica A
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A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo
Lewis, Nuruddeen D, Patnaude, Lori A, Pelletier, Josephine, Souza, Donald J, Lukas, Susan M, King, F James, Hill, Jonathan D, Stefanopoulos, Dimitria E, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christian, Hickey, Eugene R, Modis, Louise K
Published in PloS one (26.06.2014)
Published in PloS one (26.06.2014)
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Antibacterial Activity and Mechanism of Action of a Novel Anilinouracil-Fluoroquinolone Hybrid Compound
BUTLER, Michelle M, LAMARR, William A, BOWLIN, Terry L, FOSTER, Kimberly A, BARNES, Marjorie H, SKOW, Donna J, LYDEN, Patrick T, KUSTIGIAN, Lauren M, CHENGXIN ZHI, BROWN, Neal C, WRIGHT, George E
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A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay
Kashem, Mohammed A, Kennedy, Charles A, Fogarty, Kylie E, Dimock, Janice R, Zhang, Yunlong, Sanville-Ross, Mary L, Skow, Donna J, Brunette, Steven R, Swantek, Jennifer L, Hummel, Heidi S, Swindle, John, Nelson, Richard M
Published in Assay and drug development technologies (01.01.2016)
Published in Assay and drug development technologies (01.01.2016)
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Synthesis and Antibacterial Activity of 3-Substituted-6-(3-ethyl-4-methylanilino)uracils
Zhi, Chengxin, Long, Zheng-yu, Manikowski, Andrzej, Brown, Neal C, Tarantino, Paul M, Holm, Karsten, Dix, Edward J, Wright, George E, Foster, Kim A, Butler, Michelle M, LaMarr, William A, Skow, Donna J, Motorina, Irina, Lamothe, Serge, Storer, Richard
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Low frequencies of resistance among Staphylococcus and Enterococcus species to the bactericidal DNA polymerase inhibitor N(3)-hydroxybutyl 6-(3'-ethyl-4'-methylanilino) uracil
Butler, Michelle M, Skow, Donna J, Stephenson, Ryan O, Lyden, Patrick T, LaMarr, William A, Foster, Kimberly A
Published in Antimicrobial agents and chemotherapy (01.12.2002)
Published in Antimicrobial agents and chemotherapy (01.12.2002)
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Low Frequencies of Resistance among Staphylococcus and Enterococcus Species to the Bactericidal DNA Polymerase Inhibitor N3-Hydroxybutyl 6-(3′-Ethyl-4′-Methylanilino) Uracil
BUTLER, Michelle M, SKOW, Donna J, STEPHENSON, Ryan O, LYDEN, Patrick T, LAMARR, William A, FOSTER, Kimberly A
Published in Antimicrobial Agents and Chemotherapy (01.12.2002)
Published in Antimicrobial Agents and Chemotherapy (01.12.2002)
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DNA polymerase III of Enterococcus faecalis: expression and characterization of recombinant enzymes encoded by the polC and dnaE genes
Foster, Kimberly A, Barnes, Marjorie H, Stephenson, Ryan O, Butler, Michelle M, Skow, Donna J, LaMarr, William A, Brown, Neal C
Published in Protein expression and purification (01.01.2003)
Published in Protein expression and purification (01.01.2003)
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Identification of novel azaindazole CCR1 antagonist clinical candidates
Harcken, Christian, Kuzmich, Daniel, Cook, Brain, Mao, Can, Disalvo, Darren, Razavi, Hossein, Swinamer, Alan, Liu, Pingrong, Zhang, Qiang, Kukulka, Alison, Skow, Donna, Patel, Mita, Patel, Monica, Fletcher, Kimberly, Sherry, Tara, Joseph, David, Smith, Dustin, Canfield, Melissa, Souza, Donald, Bogdanffy, Matthew, Berg, Karen, Brown, Maryanne
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
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N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity
Abeywardane, Asitha, Caviness, Gary, Choi, Younggi, Cogan, Derek, Gao, Amy, Goldberg, Daniel, Heim-Riether, Alexander, Jeanfavre, Debra, Klein, Elliott, Kowalski, Jennifer A., Mao, Wang, Miller, Craig, Moss, Neil, Ramsden, Philip, Raymond, Ernest, Skow, Donna, Smith-Keenan, Lana, Snow, Roger J., Wu, Frank, Wu, Jiang-Ping, Yu, Yang
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
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A GPBAR1
Lewis, Nuruddeen D, Patnaude, Lori A, Pelletier, Josephine, Souza, Donald J, Lukas, Susan M, King, F. James, Hill, Jonathan D, Stefanopoulos, Dimitria E, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christian, Hickey, Eugene R, Modis, Louise K
Published in PloS one (26.06.2014)
Published in PloS one (26.06.2014)
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A GPBAR1 In Vivo
Lewis, Nuruddeen D, Patnaude, Lori A, Pelletier, Josephine, Souza, Donald J, Lukas, Susan M, King, F. James, Hill, Jonathan D, Stefanopoulos, Dimitria E, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christian, Hickey, Eugene R, Modis, Louise K
Published in PloS one (26.06.2014)
Published in PloS one (26.06.2014)
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G Protein–Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a K Ca 1.1 (BK Ca )–Dependent Mechanism
Fryer, Ryan M., Ng, Khing Jow, Nodop Mazurek, Suzanne G., Patnaude, Lori, Skow, Donna J., Muthukumarana, Akalushi, Gilpin, Kyle E., Dinallo, Roger M., Kuzmich, Daniel, Lord, John, Sanyal, Sulagna, Yu, Hui, Harcken, Christian, Cerny, Matthew A., Hickey, Eugene R., Modis, Louise K.
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
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Synthesis and SAR studies of indole-based MK2 inhibitors
Xiong, Zhaoming, Gao, Donghong Amy, Cogan, Derek A., Goldberg, Daniel R., Hao, Ming-Hong, Moss, Neil, Pack, Edward, Pargellis, Chris, Skow, Donna, Trieselmann, Thomas, Werneburg, Brian, White, Andre
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
Wu, Jiang-Ping, Wang, Ji, Abeywardane, Asitha, Andersen, Denise, Emmanuel, Michel, Gautschi, Elda, Goldberg, Daniel R., Kashem, Mohammed A., Lukas, Susan, Mao, Wang, Martin, Leslie, Morwick, Tina, Moss, Neil, Pargellis, Christopher, Patel, Usha R., Patnaude, Lori, Peet, Gregory W., Skow, Donna, Snow, Roger J., Ward, Yancey, Werneburg, Brian, White, Andre
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties
MOSS, Neil, CHOI, Younggi, PETERSON, J. Thomas, RAMSDEN, Philip, SARKO, Christopher, SKOW, Donna, TOMLINSON, Josh, TYE, Heather, WHITAKER, Mark, COGAN, Derek, FLEGG, Adam, KAHRS, Andreas, LOKE, Pui, MEYN, Orietta, NAGARAJA, Raj, NAPIER, Spencer, PARKER, Ashley
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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5-Aminomethylbenzimidazoles as potent ITK antagonists
RIETHER, Doris, ZINDELL, Renée, RAYMOND, Ernest L, KHINE, Hnin Hnin, O'SHEA, Kathy, WOSKA, Joseph R, JEANFAVRE, Deborah, SELLATI, Rosemarie, RALPH, Kerry L. M, AHLBERG, Jennifer, LABISSIERE, Gabriel, KASHEM, Mohammed A, KOWALSKI, Jennifer A, PULLEN, Steven S, TAKAHASHI, Hidenori, COOK, Brian N, BENTZIEN, Jörg, DE LOMBAERT, Stéphane, THOMSON, David, KUGLER, Stanley Z, SKOW, Donna, MARTIN, Leslie S
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design
Goldberg, Daniel R, Hao, Ming-Hong, Qian, Kevin C, Swinamer, Alan D, Gao, Donghong A, Xiong, Zhaoming, Sarko, Chris, Berry, Angela, Lord, John, Magolda, Ronald L, Fadra, Tazmeen, Kroe, Rachel R, Kukulka, Alison, Madwed, Jeffrey B, Martin, Leslie, Pargellis, Christopher, Skow, Donna, Song, Jinhua J, Tan, Zhulin, Torcellini, Carol A, Zimmitti, Clare S, Yee, Nathan K, Moss, Neil
Published in Journal of medicinal chemistry (23.08.2007)
Published in Journal of medicinal chemistry (23.08.2007)
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Journal Article
A new class of 5-HT 2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties
Moss, Neil, Choi, Younggi, Cogan, Derek, Flegg, Adam, Kahrs, Andreas, Loke, Pui, Meyn, Orietta, Nagaraja, Raj, Napier, Spencer, Parker, Ashley, Thomas Peterson, J., Ramsden, Philip, Sarko, Christopher, Skow, Donna, Tomlinson, Josh, Tye, Heather, Whitaker, Mark
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism
Fryer, Ryan M, Ng, Khing Jow, Nodop Mazurek, Suzanne G, Patnaude, Lori, Skow, Donna J, Muthukumarana, Akalushi, Gilpin, Kyle E, Dinallo, Roger M, Kuzmich, Daniel, Lord, John, Sanyal, Sulagna, Yu, Hui, Harcken, Christian, Cerny, Matthew A, Cerny, Matthew C, Hickey, Eugene R, Modis, Louise K
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
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