Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
Ornik-Cha, Alina, Wilhelm, Julia, Kobylka, Jessica, Sjuts, Hanno, Vargiu, Attilio V., Malloci, Giuliano, Reitz, Julian, Seybert, Anja, Frangakis, Achilleas S., Pos, Klaas M.
Published in Nature communications (25.11.2021)
Published in Nature communications (25.11.2021)
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Journal Article
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
Sjuts, Hanno, Vargiu, Attilio V., Kwasny, Steven M., Nguyen, Son T., Kim, Hong-Suk, Ding, Xiaoyuan, Ornik, Alina R., Ruggerone, Paolo, Bowlin, Terry L., Nikaido, Hiroshi, Pos, Klaas M., Opperman, Timothy J.
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
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Journal Article
Direct Comparison of Label-Free Biosensor Binding Kinetics Obtained on the Biacore 8K and the Carterra LSA
Knowling, Stuart, Clark, Jennifer, Sjuts, Hanno, Abdiche, Yasmina Noubia
Published in SLAS discovery (01.10.2020)
Published in SLAS discovery (01.10.2020)
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Journal Article
Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin
Meyer, Danilo, Neumann, Piotr, Koers, Eline, Sjuts, Hanno, Lüdtke, Stefan, Sheldrick, George M, Ficner, Ralf, Tittmann, Kai
Published in Proceedings of the National Academy of Sciences - PNAS (03.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (03.07.2012)
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Journal Article
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation
Payne, Karl A. P., Quezada, Carolina P., Fisher, Karl, Dunstan, Mark S., Collins, Fraser A., Sjuts, Hanno, Levy, Colin, Hay, Sam, Rigby, Stephen E. J., Leys, David
Published in Nature (London) (22.01.2015)
Published in Nature (London) (22.01.2015)
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Journal Article
Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria
Klingler, Franca-M, Wichelhaus, Thomas A, Frank, Denia, Cuesta-Bernal, Jenifer, El-Delik, Jasmin, Müller, H. Florian, Sjuts, Hanno, Göttig, Stephan, Koenigs, Arno, Pos, Klaas M, Pogoryelov, Denys, Proschak, Ewgenij
Published in Journal of medicinal chemistry (23.04.2015)
Published in Journal of medicinal chemistry (23.04.2015)
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Journal Article
A multivalent antibody assembled from different building blocks using tag/catcher systems: a case study
Schindler, Christof, Faust, Christine, Sjuts, Hanno, Lange, Christian, Kühn, Jennifer, Dittrich, Werner, Leuschner, Wulf Dirk, Schiebler, Werner, Hofmann, Joachim, Rao, Ercole, Langer, Thomas
Published in Protein engineering, design and selection (17.02.2022)
Published in Protein engineering, design and selection (17.02.2022)
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Journal Article
Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs
Sjuts, Hanno, Schreuder, Herman, Engel, Christian K., Bussemer, Till, Gokarn, Yatin
Published in Drug development research (01.05.2020)
Published in Drug development research (01.05.2020)
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Journal Article
Unexpected tautomeric equilibria of the carbanionenamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin
Meyer, Danilo, Neumann, Piotr, Koers, Eline, Sjuts, Hanno, Lüdtke, Stefan, Sheldrick, George M., Ficner, Ralf, Tittmann, Kai
Published in Proceedings of the National Academy of Sciences - PNAS (03.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (03.07.2012)
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Journal Article
Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification
Payne, Karl A.P., Fisher, Karl, Sjuts, Hanno, Dunstan, Mark S., Bellina, Bruno, Johannissen, Linus, Barran, Perdita, Hay, Sam, Rigby, Stephen E.J., Leys, David
Published in The Journal of biological chemistry (13.11.2015)
Published in The Journal of biological chemistry (13.11.2015)
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Journal Article
Engineered Technologies and Bioanalysis of multispecific Antibody Formats
Amaral, Marta, Hölper, Soraya, Lange, Christian, Jung, Jennifer, Sjuts, Hanno, Weil, Sandra, Fischer, Melanie, Radoevic, Katarina, Rao, Ercole
Published in Journal of applied bioanalysis (15.01.2020)
Published in Journal of applied bioanalysis (15.01.2020)
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Journal Article
Molecular Insights into Compound-Transporter Interactions: The Case of Inhibitors of Gram-Negative Bacteria Efflux Pumps
Sjuts, Hanno, Vargiu, Attilio V., Kwasny, Steven M., Nguyen, Son T., Kim, Hong-Suk, Ding, Xiaoyuan, Ornik, Alina R., Ruggerone, Paolo, Bowlin, Terry L., Nikaido, Hiroshi, Pos, Klaas M., Opperman, Timothy J.
Published in Biophysical journal (03.02.2017)
Published in Biophysical journal (03.02.2017)
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Journal Article
Correction to Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria
Klingler, Franca-M, Wichelhaus, Thomas A, Frank, Denia, Cuesta-Bernal, Jenifer, El-Delik, Jasmin, Müller, H. Florian, Sjuts, Hanno, Göttig, Stephan, Koenigs, Arno, Pos, Klaas M, Pogoryelov, Denys, Proschak, Ewgenij
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
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Journal Article
Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation
Sjuts, Hanno, Dunstan, Mark S., Fisher, Karl, Leys, David
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2015)
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2015)
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Journal Article
Humanized anti-IL-1R3 antibody and methods of use
Lange, Christian, Li, Ziyu, Weil, Sandra, Steinmann, Björn, Sjuts, Hanno
Year of Publication 06.08.2024
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Year of Publication 06.08.2024
Patent
HUMANIZED ANTI-IL-1R3 ANTIBODY AND METHODS OF USE
LANGE, Christian, STEINMANN, Björn, WEIL, Sandra, LI, Ziyu, SJUTS, Hanno
Year of Publication 28.03.2024
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Year of Publication 28.03.2024
Patent
HUMANIZED ANTI-IL-1R3 ANTIBODY AND METHODS OF USE
LANGE, Christian, STEINMANN, Björn, COOLBAUGH, Michael, WEIL, Sandra, LI, Ziyu, SJUTS, Hanno
Year of Publication 28.03.2024
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Year of Publication 28.03.2024
Patent