Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na(V)1.7 Inhibitors for the Treatment of Pain
Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G., Knox, Ronald J., Matchett, Michele, Pieschl, Rick L., Post-Munson, Debra J., Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V., Senapati, Arun, Bristow, Linda J., Meanwell, Nicholas A., Thompson, Lorin A., Dzierba, Carolyn
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
Get full text
Journal Article
Fluorine Substitution Can Block CYP3A4 Metabolism-Dependent Inhibition: Identification of (S)-N-[1-(4-Fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an Orally Bioavailable KCNQ2 Opener Devoid of CYP3A4 Metabolism-Dependent Inhibition
Wu, Yong-Jin, Davis, Carl D, Dworetzky, Steven, Fitzpatrick, William C, Harden, David, He, Huan, Knox, Ronald J, Newton, Amy E, Philip, Thomas, Polson, Craig, Sivarao, Digavalli V, Sun, Li-Qiang, Tertyshnikova, Svetlana, Weaver, David, Yeola, Suresh, Zoeckler, Mary, Sinz, Michael W
Published in Journal of medicinal chemistry (28.08.2003)
Published in Journal of medicinal chemistry (28.08.2003)
Get full text
Journal Article
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3phenylacrylamide: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine
Wu, YJ, Boissard, CG, Greco, C, Gribkoff, VK, Harden, DG, He, H, L'Heureux, A, Kang, SH, Kinney, GG, Knox, RJ, Natale, J, Newton, AE, Lehtinen-Oboma, S, Sinz, MW, Sivarao, DV, Starrett, JE, Sun, LQ, Tertyshnikova, S, Thompson, MW, Weaver, D, Wong, HS, Zhang, L, Dworetzky, SL
Published in Journal of medicinal chemistry (17.07.2003)
Published in Journal of medicinal chemistry (17.07.2003)
Get full text
Journal Article
Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca2+-Activated K+ (Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception
Sivarao, Digavalli V, Newberry, Kimberly, Langdon, Shaun, Lee, Alicia V, Hewawasam, Piyasena, Plym, Mary Jane, Signor, Laura, Myers, Robert, Lodge, Nicholas J
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Get full text
Journal Article