Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Luo, Guanglin, Rajamani, Ramkumar, Ng, Alicia, Easton, Amy, Newton, Amy, Bourin, Clotilde, Parker, Dawn, Mosure, Kathleen, Barnaby, Omar, Soars, Matthew G., Knox, Ronald J., Matchett, Michele, Pieschl, Rick, Herrington, James, Chen, Ping, Sivarao, D.V., Bristow, Linda J., Meanwell, Nicholas A., Bronson, Joanne, Olson, Richard, Thompson, Lorin A., Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry (15.10.2017)
Published in Bioorganic & medicinal chemistry (15.10.2017)
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Journal Article
Discovery of non-zwitterionic aryl sulfonamides as Na(v)1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Luo, Guanglin, Rajamani, Ramkumar, Ng, Alicia, Easton, Amy, Newton, Amy, Bourin, Clotilde, Parker, Dawn, Mosure, Kathleen, Barnaby, Omar, Soars, Matthew G., Knox, Ronald J., Matchett, Michele, Pieschl, Rick, Herrington, James, Chen, Ping, Sivarao, D. V., Bristow, Linda J., Meanwell, Nicholas A., Bronson, Joanne, Olson, Richard, Thompson, Lorin A., Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry (15.10.2017)
Published in Bioorganic & medicinal chemistry (15.10.2017)
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Journal Article
Excitation of dorsal motor vagal neurons evokes non-nicotinic receptor-mediated gastric relaxation
Krowicki, Z.K, Sivarao, D.V, Abrahams, T.P, Hornby, P.J
Published in Journal of the autonomic nervous system (24.09.1999)
Published in Journal of the autonomic nervous system (24.09.1999)
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Journal Article
Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice
Sivarao, D V, Mashimo, H L, Thatte, H S, Goyal, R K
Published in Gastroenterology (New York, N.Y. 1943) (01.07.2001)
Published in Gastroenterology (New York, N.Y. 1943) (01.07.2001)
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Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na(V)1.7 Inhibitors for the Treatment of Pain
Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G., Knox, Ronald J., Matchett, Michele, Pieschl, Rick L., Post-Munson, Debra J., Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V., Senapati, Arun, Bristow, Linda J., Meanwell, Nicholas A., Thompson, Lorin A., Dzierba, Carolyn
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Journal Article
Discovery of non-zwitterionic aryl sulfonamides as Na v 1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation
Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Luo, Guanglin, Rajamani, Ramkumar, Ng, Alicia, Easton, Amy, Newton, Amy, Bourin, Clotilde, Parker, Dawn, Mosure, Kathleen, Barnaby, Omar, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick, Herrington, James, Chen, Ping, Sivarao, D V, Bristow, Linda J, Meanwell, Nicholas A, Bronson, Joanne, Olson, Richard, Thompson, Lorin A, Dzierba, Carolyn
Published in Bioorganic & medicinal chemistry (15.10.2017)
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Published in Bioorganic & medicinal chemistry (15.10.2017)
Journal Article
Fluorine Substitution Can Block CYP3A4 Metabolism-Dependent Inhibition: Identification of (S)-N-[1-(4-Fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an Orally Bioavailable KCNQ2 Opener Devoid of CYP3A4 Metabolism-Dependent Inhibition
Wu, Yong-Jin, Davis, Carl D, Dworetzky, Steven, Fitzpatrick, William C, Harden, David, He, Huan, Knox, Ronald J, Newton, Amy E, Philip, Thomas, Polson, Craig, Sivarao, Digavalli V, Sun, Li-Qiang, Tertyshnikova, Svetlana, Weaver, David, Yeola, Suresh, Zoeckler, Mary, Sinz, Michael W
Published in Journal of medicinal chemistry (28.08.2003)
Published in Journal of medicinal chemistry (28.08.2003)
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(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3phenylacrylamide: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine
Wu, YJ, Boissard, CG, Greco, C, Gribkoff, VK, Harden, DG, He, H, L'Heureux, A, Kang, SH, Kinney, GG, Knox, RJ, Natale, J, Newton, AE, Lehtinen-Oboma, S, Sinz, MW, Sivarao, DV, Starrett, JE, Sun, LQ, Tertyshnikova, S, Thompson, MW, Weaver, D, Wong, HS, Zhang, L, Dworetzky, SL
Published in Journal of medicinal chemistry (17.07.2003)
Published in Journal of medicinal chemistry (17.07.2003)
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Journal Article
Role of GABAA receptors in rat hindbrain nuclei controlling gastric motor function
Sivarao, D V, Krowicki, Z K, Hornby, P J
Published in Neurogastroenterology and motility (01.08.1998)
Published in Neurogastroenterology and motility (01.08.1998)
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Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca2+-Activated K+ (Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception
Sivarao, Digavalli V, Newberry, Kimberly, Langdon, Shaun, Lee, Alicia V, Hewawasam, Piyasena, Plym, Mary Jane, Signor, Laura, Myers, Robert, Lodge, Nicholas J
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
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Journal Article
Excitation of dorsal motor vagal neurons evokes non-nicotinic receptor-mediated gastric relaxation
Krowicki, KZ, Sivarao, VD, Abrahams, PT, Hornby, JP
Published in Journal of the autonomic nervous system (24.09.1999)
Get full text
Published in Journal of the autonomic nervous system (24.09.1999)
Journal Article