Abstract 6401: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt and cyclin D-CDK4/6-RB pathway inhibition in hormone-receptor-positive (HR+) breast cancer models
Chung, Heekyung, Sitts, Lauren, Wu, Chu-Chiao, Eastman, Brian, Mak, Chi Ching, KC, Sunil, Stewart, Josh, Bossard, Carine, Phalen, Timothy J., Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract A09: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects in diverse ovarian cancer models
Chung, Heekyung, Sitts, Lauren, Creger, Emily, Liao, Erica, Eastman, Brian, Mak, Chi-Ching, Sunil, K.C., Tam, Betty, Bucci, Gail, Stewart, Josh, Bossard, Carine, Phalen, Timothy, Cha, Steven
Published in Clinical cancer research (01.07.2020)
Published in Clinical cancer research (01.07.2020)
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Abstract P3-13-01: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects as monotherapy and in combination with chemotherapy in triple-negative breast cancer (TNBC) models
Chung, Heekyung, Sitts, Lauren, Creger, Emily, Nguyen, John Duc, Eastman, Brian, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bossard, Carine, Phalen, Timothy, Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.02.2020)
Published in Cancer research (Chicago, Ill.) (15.02.2020)
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SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Acute Myeloid Leukemia Models
Chung, Heekyung, Creger, Emily, Sitts, Lauren, Chiu, Kevin, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Mantle Cell Lymphoma Models
Chung, Heekyung, Creger, Emily, Sitts, Lauren, Chiu, Kevin, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Tumor Protein p53 (TP53)-Mutant Acute Myeloid Leukemia Models
Chung, Heekyung, Creger, Emily, Sitts, Lauren, Chiu, Kevin, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Bucci, Gail, Stewart, Josh, Phalen, Timothy, Cha, Steven
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article