Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Zenke, Frank T, Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Kirkin, Vladimir, Pehl, Ulrich, Grombacher, Thomas, Wilm, Claudia, Fuchss, Thomas, Amendt, Christiane, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.05.2020)
Published in Molecular cancer therapeutics (01.05.2020)
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Journal Article
Functional analysis of Hsp70 inhibitors
Schlecht, Rainer, Scholz, Sebastian R, Dahmen, Heike, Wegener, Ansgar, Sirrenberg, Christian, Musil, Djordje, Bomke, Joerg, Eggenweiler, Hans-Michael, Mayer, Matthias P, Bukau, Bernd
Published in PloS one (12.11.2013)
Published in PloS one (12.11.2013)
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Journal Article
Peposertib, a DNA-PK Inhibitor, Enhances the Anti-Tumor Efficacy of Topoisomerase II Inhibitors in Triple-Negative Breast Cancer Models
Revia, Steffie, Neumann, Felix, Jabs, Julia, Orio, Florian, Sirrenberg, Christian, Zimmermann, Astrid, Amendt, Christiane, Albers, Joachim
Published in International journal of molecular sciences (08.05.2024)
Published in International journal of molecular sciences (08.05.2024)
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Journal Article
Correction: Functional Analysis of Hsp70 Inhibitors
Schlecht, Rainer, Scholz, Sebastian R., Dahmen, Heike, Wegener, Ansgar, Sirrenberg, Christian, Musil, Djordje, Bomke, Joerg, Eggenweiler, Hans-Michael, Mayer, Matthias P., Bukau, Bernd
Published in PloS one (19.12.2013)
Published in PloS one (19.12.2013)
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Journal Article
Functional Cooperation and Stoichiometry of Protein Translocases of the Outer and Inner Membranes of Mitochondria
Sirrenberg, Christian, Endres, Maxi, Becker, Karin, Bauer, Matthias F., Walther, Ernst, Neupert, Walter, Brunner, Michael
Published in The Journal of biological chemistry (21.11.1997)
Published in The Journal of biological chemistry (21.11.1997)
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Journal Article
Abstract 4183: A novel selective DNA-PK inhibitor, M3814, as a potential combination partner of Etoposide and Cisplatin in the therapy of lung cancer
Sirrenberg, Christian, Zimmermann, Astrid, Grombacher, Thomas, Vassilev, Lyubomir T., Damstrup, Lars, Zenke, Frank T., Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 338: A new investigational ATM Inhibitor, M3541, synergistically potentiates fractionated radiotherapy and chemotherapy in cancer cells and animal models
Zimmermann, Astrid, Zenke, Frank, Dahmen, Heike, Sirrenberg, Christian, Grombacher, Thomas, Vassilev, Lyubomir T., Fuchss, Thomas, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 6215: Peposertib, a DNA-PK inhibitor, enhances the antitumor efficacy of anthracyclines in triple-negative breast cancer models in vitro and in vivo
Revia, Steffie, Sirrenberg, Christian, Schach, Antonia, Zimmermann, Astrid, Zenke, Frank T., Albers, Joachim
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression
Guler, Satenig, DiPoto, Maria C., Crespo, Alejandro, Caldwell, Richard, Doerfel, Benjamin, Grossmann, Nina, Ho, Kevin, Huck, Bayard, Jones, Christopher CV, Lan, Ruoxi, Musil, Djordje, Potnick, Justin, Schilke, Heike, Sherer, Brian, Simon, Stephanie, Sirrenberg, Christian, Zhang, Zhuo, Liu-Bujalski, Lesley
Published in ACS medicinal chemistry letters (11.05.2023)
Published in ACS medicinal chemistry letters (11.05.2023)
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Journal Article
Abstract 1658: M3814, a novel investigational DNA-PK inhibitor: enhancing the effect of fractionated radiotherapy leading to complete regression of tumors in mice
Zenke, Frank T., Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Vassilev, Lubo, Pehl, Ulrich, Fuchss, Thomas, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 4198: Highly potent and selective DNA-PK inhibitor M3814 with sustainable anti-tumor activity in combination with radiotherapy
Fuchss, Thomas, Mederski, Werner W., Emde, Ulrich, Buchstallter, Hans-Peter, Zenke, Frank, Zimmermann, Astrid, Sirrenberg, Christian, Vassilev, Lubo, Damstrup, Lars, Urbahns, Klaus, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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단백질 키나제 억제제 및 추가 화학요법제의 조합물
DAMSTRUP LARS, VASSILEV LYUBOMIR, ZIMMERMANN ASTRID, GROMBACHER THOMAS, SIRRENBERG CHRISTIAN
Year of Publication 26.08.2019
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Year of Publication 26.08.2019
Patent
Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors
Buchstaller, Hans-Peter, Burgdorf, Lars, Finsinger, Dirk, Stieber, Frank, Sirrenberg, Christian, Amendt, Christiane, Grell, Matthias, Zenke, Frank, Krier, Mireille
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90
Buchstaller, Hans-Peter, Eggenweiler, Hans-Michael, Sirrenberg, Christian, Grädler, Ulrich, Musil, Djordje, Hoppe, Edmund, Zimmermann, Astrid, Schwartz, Harry, März, Joachim, Bomke, Jörg, Wegener, Ansgar, Wolf, Michael
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
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A Novel Strategy for ADME Screening of Prodrugs: Combined Use of Serum and Hepatocytes to Integrate Bioactivation and Clearance, and Predict Exposure to Both Active and Prodrug to the Systemic Circulation
Hoppe, Edmund, Hewitt, Nicola J., Buchstaller, Hans-Peter, Eggenweiler, Hans-Michael, Sirrenberg, Christian, Zimmermann, Astrid, März, Joachim, Schwartz, Harry, Saal, Christoph, Meyring, Michael, Hecht, Stefan
Published in Journal of pharmaceutical sciences (01.05.2014)
Published in Journal of pharmaceutical sciences (01.05.2014)
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Journal Article
Tim9, a new component of the TIM22·54 translocase in mitochondria
Adam, Alexander, Endres, Maxi, Sirrenberg, Christian, Lottspeich, Friedrich, Neupert, Walter, Brunner, Michael
Published in The EMBO journal (15.01.1999)
Published in The EMBO journal (15.01.1999)
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Journal Article
Role of Tim23 as Voltage Sensor and Presequence Receptor in Protein Import into Mitochondria
Bauer, Matthias F, Sirrenberg, Christian, Neupert, Walter, Brunner, Michael
Published in Cell (04.10.1996)
Published in Cell (04.10.1996)
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Journal Article
Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22
Sirrenberg, Christian, Bauer, Matthias F, Guiard, Bernard, Neupert, Walter, Brunner, Michael
Published in Nature (London) (12.12.1996)
Published in Nature (London) (12.12.1996)
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Dissecting the role of matrix metalloproteinases (MMP) and integrin αvβ3 in angiogenesis in vitro : Absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and αvβ3 are critical
NISATO, Riccardo E, HOSSEINI, Ghamartaj, PEPPER, Michael S, SIRRENBERG, Christian, BUTLER, Georgina S, CRABBE, Thomas, DOCHERTY, Andrew J. P, WIESNER, Matthias, MURPHY, Gillian, OVERALL, Christopher M, GOODMAN, Simon L
Published in Cancer research (Chicago, Ill.) (15.10.2005)
Published in Cancer research (Chicago, Ill.) (15.10.2005)
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