Evaluation of various static and dynamic modeling methods to predict clinical CYP3A induction using in vitro CYP3A4 mRNA induction data
Einolf, H J, Chen, L, Fahmi, O A, Gibson, C R, Obach, R S, Shebley, M, Silva, J, Sinz, M W, Unadkat, J D, Zhang, L, Zhao, P
Published in Clinical pharmacology and therapeutics (01.02.2014)
Published in Clinical pharmacology and therapeutics (01.02.2014)
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Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective
Fahmi, Odette A, Shebley, Mohamad, Palamanda, Jairam, Sinz, Michael W, Ramsden, Diane, Einolf, Heidi J, Chen, Liangfu, Wang, Hongbing
Published in Drug metabolism and disposition (01.10.2016)
Published in Drug metabolism and disposition (01.10.2016)
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Cytochrome P450 reaction-phenotyping: an industrial perspective
Zhang, Hongjian, Davis, Carl D, Sinz, Michael W, Rodrigues, A David
Published in Expert opinion on drug metabolism & toxicology (01.10.2007)
Published in Expert opinion on drug metabolism & toxicology (01.10.2007)
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Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice
He, Kan, Iyer, Krishna R, Hayes, Roger N, Sinz, Michael W, Woolf, Thomas F, Hollenberg, Paul F
Published in Chemical research in toxicology (01.04.1998)
Published in Chemical research in toxicology (01.04.1998)
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Journal Article
Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system
Selvakumar, Sindhuja, Bhutani, Priyadeep, Ghosh, Kaushik, Krishnamurthy, Prasad, Kallipatti, Sanjith, Selvam, Sabariya, Ramarao, Manjunath, Mandlekar, Sandhya, Sinz, Michael W, Rodrigues, A David, Subramanian, Murali
Published in Drug metabolism and disposition (01.03.2014)
Published in Drug metabolism and disposition (01.03.2014)
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Journal Article
Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC–MS/MS analysis
Yao, Ming, Zhu, Mingshe, Sinz, Michael W., Zhang, Hongjian, Humphreys, W. Griffith, Rodrigues, A. David, Dai, Renke
Published in Journal of pharmaceutical and biomedical analysis (09.05.2007)
Published in Journal of pharmaceutical and biomedical analysis (09.05.2007)
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Journal Article
Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs
Whiterock, Valerie J, Morgan, Daniel G, Lentz, Kimberley A, Orcutt, Tami L, Sinz, Michael W
Published in Drug metabolism and disposition (01.02.2012)
Published in Drug metabolism and disposition (01.02.2012)
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Journal Article
The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Jie, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley V., Zheng, Barbara, Hewawasam, Piyasena, Tu, Yong, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Levine, Steven, Chen, Chaoqun, Yu, Fei, Sheaffer, Amy K., Zhai, Guangzhi, Barry, Diana, Knipe, Jay O., Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W., Zvyaga, Tatyana, Good, Andrew C., Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E., Gao, Qi, Mueller, Luciano, Colonno, Richard J., Grasela, Dennis M., Adams, Stephen P., Loy, James, Levesque, Paul C., Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Comparative Effects of Thiazolidinediones on in Vitro P450 Enzyme Induction and Inhibition
SAHI, Jasminder, BLACK, Christopher B, HAMILTON, Geraldine A, XIANXIAN ZHENG, JOLLEY, Summer, ROSE, Kelly A, GILBERT, Darryl, LECLUYSE, Edward L, SINZ, Michael W
Published in Drug metabolism and disposition (01.04.2003)
Published in Drug metabolism and disposition (01.04.2003)
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Journal Article
Required length of guardrails before hazards
Tomasch, E., Sinz, W., Hoschopf, H., Gobald, M., Steffan, H., Nadler, B., Nadler, F., Strnad, B., Schneider, F.
Published in Accident analysis and prevention (01.11.2011)
Published in Accident analysis and prevention (01.11.2011)
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Journal Article
Fluorine Substitution Can Block CYP3A4 Metabolism-Dependent Inhibition: Identification of (S)-N-[1-(4-Fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an Orally Bioavailable KCNQ2 Opener Devoid of CYP3A4 Metabolism-Dependent Inhibition
Wu, Yong-Jin, Davis, Carl D, Dworetzky, Steven, Fitzpatrick, William C, Harden, David, He, Huan, Knox, Ronald J, Newton, Amy E, Philip, Thomas, Polson, Craig, Sivarao, Digavalli V, Sun, Li-Qiang, Tertyshnikova, Svetlana, Weaver, David, Yeola, Suresh, Zoeckler, Mary, Sinz, Michael W
Published in Journal of medicinal chemistry (28.08.2003)
Published in Journal of medicinal chemistry (28.08.2003)
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Journal Article
integrated physical and genetic map of the nematode Pristionchus pacificus
Srinivasan, J, Sinz, W, Jesse, T, Wiggers-Perebolte, L, Jansen, K, Buntjer, J, van der Meulen, M, Sommer, R. J
Published in Molecular genetics and genomics : MGG (01.08.2003)
Published in Molecular genetics and genomics : MGG (01.08.2003)
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Journal Article
The Effect of Troglitazone Biliary Excretion on Metabolite Distribution and Cholestasis in Transporter-Deficient Rats
KOSTRUBSKY, Vsevolod E, VORE, Mary, KINDT, Erick, BURLIEGH, James, ROGERS, Karen, PETER, Gregory, ALTROGGE, Douglas, SINZ, Michael W
Published in Drug metabolism and disposition (01.12.2001)
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Published in Drug metabolism and disposition (01.12.2001)
Journal Article
Metabolism and transporter-mediated drug–drug interactions of the endothelin-A receptor antagonist CI-1034
Sahi, Jasminder, Sinz, Michael W., Campbell, Scott, Mireles, Rouchelle, Zheng, Xianxian, Rose, Kelly A., Raeissi, Shamsi, Hashim, Muhammed F., Ye, Yuyang, de Morais, Sonia M., Black, Christopher, Tugnait, Meera, Keller, Laurence H.
Published in Chemico-biological interactions (01.02.2006)
Published in Chemico-biological interactions (01.02.2006)
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Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1
Markwalder, Jay A., Balog, Aaron J., Williams, David K., Nara, Susheel J., Reddy, Ratnakar, Roy, Saumya, Kanyaboina, Yadagiri, Li, Xin, Johnston, Kathy, Fan, Yi, Lewis, Hal, Marsilio, Frank, Yan, Chunhong, Critton, David, Newitt, John A., Traeger, Sarah C., Wu, Dauh-Rurng, Jure-Kunkel, Maria N., Jayaraman, Lata, Lin, Tai-An, Sinz, Michael W., Hunt, John T., Seitz, Steven P.
Published in Bioorganic & medicinal chemistry letters (15.05.2023)
Published in Bioorganic & medicinal chemistry letters (15.05.2023)
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Journal Article
Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism
Li, Linhao, Sinz, Michael W, Zimmermann, Kurt, Wang, Hongbing
Published in The Journal of pharmacology and experimental therapeutics (01.03.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2012)
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Animal models of xenobiotic receptors in drug metabolism and diseases
Gong, Haibiao, Sinz, Michael W, Feng, Yan, Chen, Taosheng, Venkataramanan, Raman, Xie, Wen
Published in Methods in enzymology (2005)
Published in Methods in enzymology (2005)
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