Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway
Gavin, James M., Hoar, Kara, Xu, Qing, Ma, Jingya, Lin, Yafang, Chen, Jiejin, Chen, Wei, Bruzzese, Frank J., Harrison, Sean, Mallender, William D., Bump, Nancy J., Sintchak, Michael D., Bence, Neil F., Li, Ping, Dick, Lawrence R., Gould, Alexandra E., Chen, Jesse J.
Published in The Journal of biological chemistry (15.08.2014)
Published in The Journal of biological chemistry (15.08.2014)
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Life on Carbon Monoxide: X-Ray Structure of Rhodospirillum rubrum Ni-Fe-S Carbon Monoxide Dehydrogenase
Drennan, Catherine L., Heo, Jongyun, Sintchak, Michael D., Schreiter, Eric, Ludden, Paul W.
Published in Proceedings of the National Academy of Sciences - PNAS (09.10.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (09.10.2001)
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Crystal structure of the nickel-responsive transcription factor NikR
Drennan, Catherine L, Schreiter, Eric R, Sintchak, Michael D, Guo, Yayi, Chivers, Peter T, Sauer, Robert T
Published in Nature structural & molecular biology (01.10.2003)
Published in Nature structural & molecular biology (01.10.2003)
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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
Griffith, James P, Kim, Joseph L, Kim, Eunice E, Sintchak, Michael D, Thomson, John A, Fitzgibbon, Matthew J, Fleming, Mark A, Caron, Paul R, Hsiao, Kathy, Navia, Manuel A
Published in Cell (11.08.1995)
Published in Cell (11.08.1995)
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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Soucy, Teresa A., Smith, Peter G., Milhollen, Michael A., Berger, Allison J., Gavin, James M., Adhikari, Sharmila, Brownell, James E., Burke, Kristine E., Cardin, David P., Critchley, Stephen, Cullis, Courtney A., Doucette, Amanda, Garnsey, James J., Gaulin, Jeffrey L., Gershman, Rachel E., Lublinsky, Anna R., McDonald, Alice, Mizutani, Hirotake, Narayanan, Usha, Olhava, Edward J., Peluso, Stephane, Rezaei, Mansoureh, Sintchak, Michael D., Talreja, Tina, Thomas, Michael P., Traore, Tary, Vyskocil, Stepan, Weatherhead, Gabriel S., Yu, Jie, Zhang, Julie, Dick, Lawrence R., Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Langston, Steven P.
Published in Nature (09.04.2009)
Published in Nature (09.04.2009)
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Journal Article
Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ
Brownell, James E., Sintchak, Michael D., Gavin, James M., Liao, Hua, Bruzzese, Frank J., Bump, Nancy J., Soucy, Teresa A., Milhollen, Michael A., Yang, Xiaofeng, Burkhardt, Anne L., Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Wu, Dongyun, Hamman, Kristin B., Spelman, James J., Cullis, Courtney A., Langston, Steven P., Vyskocil, Stepan, Sells, Todd B., Mallender, William D., Visiers, Irache, Li, Ping, Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Dick, Lawrence R.
Published in Molecular cell (15.01.2010)
Published in Molecular cell (15.01.2010)
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Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues
Chen, Jesse J., Tsu, Christopher A., Gavin, James M., Milhollen, Michael A., Bruzzese, Frank J., Mallender, William D., Sintchak, Michael D., Bump, Nancy J., Yang, Xiaofeng, Ma, Jingya, Loke, Huay-Keng, Xu, Qing, Li, Ping, Bence, Neil F., Brownell, James E., Dick, Lawrence R.
Published in The Journal of biological chemistry (25.11.2011)
Published in The Journal of biological chemistry (25.11.2011)
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Journal Article
Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome
Blackburn, Christopher, Barrett, Cynthia, Blank, Jonathan L., Bruzzese, Frank J., Bump, Nancy, Dick, Lawrence R., Fleming, Paul, Garcia, Khristofer, Hales, Paul, Hu, Zhigen, Jones, Matthew, Liu, Jane X., Sappal, Darshan S., Sintchak, Michael D., Tsu, Christopher, Gigstad, Kenneth M.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905)
Duffey, Matthew O, Vos, Tricia J, Adams, Ruth, Alley, Jennifer, Anthony, Justin, Barrett, Cynthia, Bharathan, Indu, Bowman, Douglas, Bump, Nancy J, Chau, Ryan, Cullis, Courtney, Driscoll, Denise L, Elder, Amy, Forsyth, Nancy, Frazer, Jonathan, Guo, Jianping, Guo, Luyi, Hyer, Marc L, Janowick, David, Kulkarni, Bheemashankar, Lai, Su-Jen, Lasky, Kerri, Li, Gang, Li, Jing, Liao, Debra, Little, Jeremy, Peng, Bo, Qian, Mark G, Reynolds, Dominic J, Rezaei, Mansoureh, Scott, Margaret Porter, Sells, Todd B, Shinde, Vaishali, Shi, Qiuju Judy, Sintchak, Michael D, Soucy, Francois, Sprott, Kevin T, Stroud, Stephen G, Nestor, Michelle, Visiers, Irache, Weatherhead, Gabriel, Ye, Yingchun, D’Amore, Natalie
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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Inhibition of IMPDH by Mycophenolic Acid: Dissection of Forward and Reverse Pathways Using Capillary Electrophoresis
Fleming, Mark A, Chambers, Stephen P, Connelly, Patrick R, Nimmesgern, Elmar, Fox, Ted, Bruzzese, Frank J, Hoe, Stephen T, Fulghum, John R, Livingston, David J, Stuver, Cameron M, Sintchak, Michael D, Wilson, Keith P, Thomson, John A
Published in Biochemistry (Easton) (04.06.1996)
Published in Biochemistry (Easton) (04.06.1996)
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The structure of inosine 5′-monophosphate dehydrogenase and the design of novel inhibitors
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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer
Langston, Steven P, Grossman, Stephen, England, Dylan, Afroze, Roushan, Bence, Neil, Bowman, Douglas, Bump, Nancy, Chau, Ryan, Chuang, Bei-Ching, Claiborne, Christopher, Cohen, Larry, Connolly, Kelly, Duffey, Matthew, Durvasula, Nitya, Freeze, Scott, Gallery, Melissa, Galvin, Katherine, Gaulin, Jeffrey, Gershman, Rachel, Greenspan, Paul, Grieves, Jessica, Guo, Jianping, Gulavita, Nanda, Hailu, Shumet, He, Xingyue, Hoar, Kara, Hu, Yongbo, Hu, Zhigen, Ito, Mitsuhiro, Kim, Mi-Sook, Lane, Scott Weston, Lok, David, Lublinsky, Anya, Mallender, William, McIntyre, Charles, Minissale, James, Mizutani, Hirotake, Mizutani, Miho, Molchinova, Nina, Ono, Koji, Patil, Ashok, Qian, Mark, Riceberg, Jessica, Shindi, Vaishali, Sintchak, Michael D, Song, Keli, Soucy, Teresa, Wang, Yana, Xu, He, Yang, Xiaofeng, Zawadzka, Agatha, Zhang, Ji, Pulukuri, Sai M
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
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Biochemical Analysis of the Modular Enzyme Inosine 5′-Monophosphate Dehydrogenase
Nimmesgern, Elmar, Black, James, Futer, Olga, Fulghum, John R., Chambers, Stephen P., Brummel, Christopher L., Raybuck, Scott A., Sintchak, Michael D.
Published in Protein expression and purification (01.11.1999)
Published in Protein expression and purification (01.11.1999)
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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins
Ackloo, Suzanne, Li, Fengling, Szewczyk, Magda, Seitova, Almagul, Loppnau, Peter, Zeng, Hong, Xu, Jin, Ahmad, Shabbir, Arnautova, Yelena A, Baghaie, A J, Beldar, Serap, Bolotokova, Albina, Centrella, Paolo A, Chau, Irene, Clark, Matthew A, Cuozzo, John W, Dehghani-Tafti, Saba, Disch, Jeremy S, Dong, Aiping, Dumas, Antoine, Feng, Jianwen A, Ghiabi, Pegah, Gibson, Elisa, Gilmer, Justin, Goldman, Brian, Green, Stuart R, Guié, Marie-Aude, Guilinger, John P, Harms, Nathan, Herasymenko, Oleksandra, Houliston, Scott, Hutchinson, Ashley, Kearnes, Steven, Keefe, Anthony D, Kimani, Serah W, Kramer, Trevor, Kutera, Maria, Kwak, Haejin A, Lento, Cristina, Li, Yanjun, Liu, Jenny, Loup, Joachim, Machado, Raquel A C, Mulhern, Christopher J, Perveen, Sumera, Righetto, Germanna L, Riley, Patrick, Shrestha, Suman, Sigel, Eric A, Silva, Madhushika, Sintchak, Michael D, Slakman, Belinda L, Taylor, Rhys D, Thompson, James, Torng, Wen, Underkoffler, Carl, von Rechenberg, Moritz, Walsh, Ryan T, Watson, Ian, Wilson, Derek J, Wolf, Esther, Yadav, Manisha, Yazdi, Aliakbar K, Zhang, Junyi, Zhang, Ying, Santhakumar, Vijayaratnam, Edwards, Aled M, Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Brown, Peter J, Halabelian, Levon, Arrowsmith, Cheryl H
Published in Journal of medicinal chemistry (04.11.2024)
Published in Journal of medicinal chemistry (04.11.2024)
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HETEROARYLS AND USES THEREOF
D'AMORE NATALIE, STROUD STEPHEN G, HU YONGBO, REZAEI MANSOUREH, SOUCY FRANCOIS, BHARATHAN INDU T, XU HE, CHOUITAR JOUHARA, CIAVARRI JEFFREY P, FLEMING PAUL E, YE YINGCHUN, CULLIS COURTNEY A, GIPSON KRISTA E, XU TIANLIN, GIGSTAD KENNETH M, BLACKBURN CHRIS, GIRARD MARIO, LEE JANICE, SINTCHAK MICHAEL D, WONG TZU TSHIN, VOS TRICIA J, LI GANG
Year of Publication 24.10.2016
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Year of Publication 24.10.2016
Patent
Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin
Kossiakoff, A A, Sintchak, M D, Shpungin, J, Presta, L G
Published in Proteins, structure, function, and bioinformatics (01.03.1992)
Published in Proteins, structure, function, and bioinformatics (01.03.1992)
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Journal Article
A mutational analysis of the active site of human type II inosine 5′-monophosphate dehydrogenase
Futer, Olga, Sintchak, Michael D., Caron, Paul R., Nimmesgern, Elmar, DeCenzo, Maureen T., Livingston, David J., Raybuck, Scott A.
Published in Biochimica et biophysica acta (31.01.2002)
Published in Biochimica et biophysica acta (31.01.2002)
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Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors
Gould, Alexandra E, Adams, Ruth, Adhikari, Sharmila, Aertgeerts, Kathleen, Afroze, Roushan, Blackburn, Christopher, Calderwood, Emily F, Chau, Ryan, Chouitar, Jouhara, Duffey, Matthew O, England, Dylan B, Farrer, Cheryl, Forsyth, Nancy, Garcia, Khristofer, Gaulin, Jeffery, Greenspan, Paul D, Guo, Ribo, Harrison, Sean J, Huang, Shih-Chung, Iartchouk, Natalia, Janowick, Dave, Kim, Mi-Sook, Kulkarni, Bheemashankar, Langston, Steven P, Liu, Jane X, Ma, Li-Ting, Menon, Saurabh, Mizutani, Hirotake, Paske, Erin, Renou, Christelle C, Rezaei, Mansoureh, Rowland, R. Scott, Sintchak, Michael D, Smith, Michael D, Stroud, Stephen G, Tregay, Ming, Tian, Yuan, Veiby, Ole P, Vos, Tricia J, Vyskocil, Stepan, Williams, Juliet, Xu, Tianlin, Yang, Johnny J, Yano, Jason, Zeng, Hongbo, Zhang, Dong Mei, Zhang, Qin, Galvin, Katherine M
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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