Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer
Datta, Jashodeep, Dai, Xizi, Bianchi, Anna, De Castro Silva, Iago, Mehra, Siddharth, Garrido, Vanessa T., Lamichhane, Purushottam, Singh, Samara P., Zhou, Zhiqun, Dosch, Austin R., Messaggio, Fanuel, Ban, Yuguang, Umland, Oliver, Hosein, Peter J., Nagathihalli, Nagaraj S., Merchant, Nipun B.
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2022)
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Journal Article
Emerging Role of CREB in Epithelial to Mesenchymal Plasticity of Pancreatic Cancer
Mehra, Siddharth, Singh, Samara, Nagathihalli, Nagaraj
Published in Frontiers in oncology (21.06.2022)
Published in Frontiers in oncology (21.06.2022)
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Journal Article
Tumor Cell-Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer
Singh, Samara P, Dosch, Austin R, Mehra, Siddharth, De Castro Silva, Iago, Bianchi, Anna, Garrido, Vanessa T, Zhou, Zhiqun, Adams, Andrew, Amirian, Haleh, Box, Edmond W, Sun, Xiaodian, Ban, Yuguang, Datta, Jashodeep, Nagathihalli, Nagaraj S, Merchant, Nipun B
Published in Cancer research (Chicago, Ill.) (15.04.2024)
Published in Cancer research (Chicago, Ill.) (15.04.2024)
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Journal Article
A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers
Singh, Sunanda, Murillo, Genoveva, Richner, Justin, Singh, Samara P., Berleth, Erica, Kumar, Vijay, Mehta, Rajendra, Ramiya, Vijay, Parihar, Ashutosh S.
Published in International journal of molecular sciences (08.07.2022)
Published in International journal of molecular sciences (08.07.2022)
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Journal Article
Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer
Mehra, Siddharth, Garrido, Vanessa T, Dosch, Austin R, Lamichhane, Purushottam, Srinivasan, Supriya, Singh, Samara P, Zhou, Zhiqun, De Castro Silva, Iago, Joshi, Chandrashekar, Ban, Yuguang, Datta, Jashodeep, Gilboa, Eli, Merchant, Nipun B, Nagathihalli, Nagaraj S
Published in Cancer research communications (01.07.2023)
Published in Cancer research communications (01.07.2023)
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Journal Article
557 Chronicity of exposure and ensuing resistance to platinum chemotherapy sensitizes homologous recombination-deficient pancreatic ductal adenocarcinoma to immune checkpoint blockade
Ogobuiro, Ifeanyichukwu, Bianchi, Anna, Caeiro, Lucas, Amirian, Haleh, Nivelo, Luis Alberto, Silva, Iago De Castro, Rajkumar, Karthik, Adams, Andrew, Garrido, Vanessa, Singh, Samara, Nagathihalli, Nagaraj, Merchant, Nipun, Datta, Jashodeep
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Microbial influences on severity and sex bias of systemic autoimmunity
Lee, Jean, Reiman, Derek, Singh, Samara, Chang, Anthony, Morel, Laurence, Chervonsky, Alexander V.
Published in Immunological reviews (01.08.2024)
Published in Immunological reviews (01.08.2024)
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Journal Article
Su1179 MICROBIAL METABOLITE UROLITHIN A REDUCES INFLAMMATION AND ENHANCES GUT BARRIER FUNCTION IN KRASG12D INHIBITOR MRTX1133-TREATED MOUSE MODELS OF PANCREATIC CANCER
Krishnamoorthy, Varunkumar, Mehra, Siddharth, Jinka, Sudhakar, Amirian, Haleh, Box, Edmond Worley, Singh, Samara, Dickey, Erin M., Jala, Venkatakrishna R., Datta, Jashodeep, Merchant, Nipun, Nagathihalli, Nagaraj
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
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Journal Article
Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer
Dosch, Austin R, Singh, Samara, Dai, Xizi, Mehra, Siddharth, Silva, Iago De Castro, Bianchi, Anna, Srinivasan, Supriya, Gao, Zhen, Ban, Yuguang, Chen, Xi, Banerjee, Sulagna, Nagathihalli, Nagaraj S, Datta, Jashodeep, Merchant, Nipun B
Published in Molecular cancer therapeutics (01.11.2021)
Published in Molecular cancer therapeutics (01.11.2021)
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Journal Article
Neutrophil Attenuation Improves Chemosensitivity by Mitigating Inflammatory Polarization of Cancer-Associated Fibroblasts in Pancreatic Cancer
de Castro Silva, Iago, Bianchi, Anna, Deshpande, Nilesh U, Garrido, Vanessa C, Singh, Samara, Mehra, Siddharth, Zhou, Zhiqun, Ogobuiro, Ifeanyichukwu C, Merchant, Nipun B, Datta, Jashodeep
Published in Journal of the American College of Surgeons (01.11.2022)
Published in Journal of the American College of Surgeons (01.11.2022)
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Journal Article
Interleukin-1 signaling in solid organ malignancies
Dosch, Austin R., Singh, Samara, Nagathihalli, Nagaraj S., Datta, Jashodeep, Merchant, Nipun B.
Published in Biochimica et biophysica acta. Reviews on cancer (01.01.2022)
Published in Biochimica et biophysica acta. Reviews on cancer (01.01.2022)
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Journal Article
Application of Nano-Antibodies for Cancer Immunotherapy
Singh, Sunanda, Singh, Samara P., Parihar, Ashutosh S.
Published in Current tissue microenvironment reports (12.04.2023)
Published in Current tissue microenvironment reports (12.04.2023)
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Journal Article
Abstract 1544: Cell penetrating single domain antibody (sdAb) SBT-100 binds KRAS and inhibits growth of human cancers with KRAS activating mutations
Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi, Singh, Anjali, Mehta, Rajendra, Parihar, Ashutosh
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer
Datta, Jashodeep, Bianchi, Anna, De Castro Silva, Iago, Deshpande, Nilesh U., Cao, Long Long, Mehra, Siddharth, Singh, Samara, Rafie, Christine, Sun, Xiaodian, Chen, Xi, Dai, Xizi, Colaprico, Antonio, Sharma, Prateek, Dosch, Austin R., Pillai, Asha, Hosein, Peter J., Nagathihalli, Nagaraj S., Komanduri, Krishna V., Wilson, Julie M., Ban, Yuguang, Merchant, Nipun B.
Published in Oncogene (08.07.2022)
Published in Oncogene (08.07.2022)
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Journal Article
Attenuating Neutrophil-to-lymphocyte Ratio Potentiates Sensitivity to Chemotherapy in a Murine Model of Pancreatic Ductal Adenocarcinoma
de Castro Silva, Iago, Deshpande, Nilesh U., Bianchi, Anna, Sharma, Prateek, Dosch, Austin R., Singh, Samara, Nagathihalli, Nagaraj S., Merchant, Nipun B., Datta, Jashodeep
Published in Journal of the American College of Surgeons (01.11.2021)
Published in Journal of the American College of Surgeons (01.11.2021)
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Journal Article
Abstract 5436: Novel single-domain antibody (sdAb), SBT-100, localizes in the cytoplasm to inhibit IL-6 mediated P-STAT3 nuclear translocation in cancer cells
Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi, Mehta, Rajendra, Singh, Anjali, Parihar, Ashutosh
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract PO-046: Dissecting the role of tumor-intrinsic Cxcl1 in mediating immune exclusion in Ras-p53 cooperative pancreatic cancer
Bianchi, Anna, Mehra, Siddharth, Dai, Daisy, de Castro Silva, Iago, Sharma, Prateek, Colaprico, Antonio, Dosch, Austin R., Singh, Samara, Nagathihalli, Nagaraj S., Merchant, Nipun B., Datta, Jashodeep
Published in Cancer research (Chicago, Ill.) (15.11.2020)
Published in Cancer research (Chicago, Ill.) (15.11.2020)
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Journal Article
Abstract PO-056: Targeting of cancer associated fibroblast-specific MEK1 and STAT3 to overcome immunosuppressive microenvironment in Pancreatic Ductal Adenocarcinoma (PDAC)
Mehra, Siddharth, Dai, Xizi, Bianchi, Anna, Dosch, Austin, de Castro Silva, Iago, Sharma, Prateek, Singh, Samara, Srinivasan, Supriya, Nagathihalli, Nagaraj, Datta, Jashodeep, Merchant, Nipun
Published in Cancer research (Chicago, Ill.) (15.11.2020)
Published in Cancer research (Chicago, Ill.) (15.11.2020)
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