Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function
Pobezinsky, Leonid A, Etzensperger, Ruth, Jeurling, Susanna, Alag, Amala, Kadakia, Tejas, McCaughtry, Tom M, Kimura, Motoko Y, Sharrow, Susan O, Guinter, Terry I, Feigenbaum, Lionel, Singer, Alfred
Published in Nature immunology (01.05.2015)
Published in Nature immunology (01.05.2015)
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T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences
Madi, Asaf, Poran, Asaf, Shifrut, Eric, Reich-Zeliger, Shlomit, Greenstein, Erez, Zaretsky, Irena, Arnon, Tomer, Laethem, Francois Van, Singer, Alfred, Lu, Jinghua, Sun, Peter D, Cohen, Irun R, Friedman, Nir
Published in eLife (21.07.2017)
Published in eLife (21.07.2017)
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Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
Lu, Jinghua, Van Laethem, François, Bhattacharya, Abhisek, Craveiro, Marco, Saba, Ingrid, Chu, Jonathan, Love, Nicholas C, Tikhonova, Anastasia, Radaev, Sergei, Sun, Xiaoping, Ko, Annette, Arnon, Tomer, Shifrut, Eric, Friedman, Nir, Weng, Nan-Ping, Singer, Alfred, Sun, Peter D
Published in Nature communications (04.03.2019)
Published in Nature communications (04.03.2019)
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MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction
Van Laethem, François, Bhattacharya, Abhisek, Craveiro, Marco, Lu, Jinghua, Sun, Peter D., Singer, Alfred
Published in Frontiers in immunology (14.07.2022)
Published in Frontiers in immunology (14.07.2022)
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The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling
Luckey, Megan A, Kimura, Motoko Y, Waickman, Adam T, Feigenbaum, Lionel, Singer, Alfred, Park, Jung-Hyun
Published in Nature immunology (01.07.2014)
Published in Nature immunology (01.07.2014)
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Journal Article
Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors
Kimura, Motoko Y, Thomas, Julien, Tai, Xuguang, Guinter, Terry I, Shinzawa, Miho, Etzensperger, Ruth, Li, Zhenhu, Love, Paul, Nakayama, Toshinori, Singer, Alfred
Published in Nature immunology (01.12.2016)
Published in Nature immunology (01.12.2016)
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Journal Article
Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation
Gegonne, Anne, Chen, Qing-Rong, Dey, Anup, Etzensperger, Ruth, Tai, Xuguang, Singer, Alfred, Meerzaman, Daoud, Ozato, Keiko, Singer, Dinah S.
Published in Cell reports (Cambridge) (03.07.2018)
Published in Cell reports (Cambridge) (03.07.2018)
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'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
Lucas, Philip J, Erman, Batu, Ellmeier, Wilfried, Singer, Alfred, Park, Jung-Hyun, Liu, Xiaolong, Feigenbaum, Lionel, Alag, Amala S, Sarafova, Sophia D, Adoro, Stanley, Doan, Loretta L, Bosselut, Remy
Published in Nature Immunology (01.10.2007)
Published in Nature Immunology (01.10.2007)
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Induction of autoimmune disease in CTLA-4⁻/⁻ mice depends on a specific CD28 motif that is required for in vivo costimulation
Tai, Xuguang, Van Laethem, Francois, Sharpe, Arlene H, Singer, Alfred
Published in Proceedings of the National Academy of Sciences - PNAS (21.08.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (21.08.2007)
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Journal Article
CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation
Kimura, Motoko Y., Igi, Akemi, Hayashizaki, Koji, Mita, Yukiyoshi, Shinzawa, Miho, Kadakia, Tejas, Endo, Yukihiro, Ogawa, Satomi, Yagi, Ryoji, Motohashi, Shinichiro, Singer, Alfred, Nakayama, Toshinori
Published in Nature communications (14.09.2018)
Published in Nature communications (14.09.2018)
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Journal Article
Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus
Van Laethem, François, Saba, Ingrid, Lu, Jinghua, Bhattacharya, Abhisek, Tai, Xuguang, Guinter, Terry I, Engelhardt, Britta, Alag, Amala, Rojano, Mirelle, Ashe, Jennifer M, Hanada, Ken-Ichi, Yang, James C, Sun, Peter D, Singer, Alfred
Published in Frontiers in immunology (16.06.2020)
Published in Frontiers in immunology (16.06.2020)
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Journal Article
The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells
Gegonne, Anne, Tai, Xuguang, Zhang, Jinghui, Wu, Gang, Zhu, Jianjian, Yoshimoto, Aki, Hanson, Jeffrey, Cultraro, Constance, Chen, Qing-Rong, Guinter, Terry, Yang, Zhihui, Hathcock, Karen, Singer, Alfred, Rodriguez-Canales, Jaime, Tessarollo, Lino, Mackem, Susan, Meerzaman, Daoud, Buetow, Ken, Singer, Dinah S.
Published in Molecular and Cellular Biology (01.05.2012)
Published in Molecular and Cellular Biology (01.05.2012)
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Coreceptor gene "imprinting:" A genetic solution to a developmental dilemma in T cells
Adoro, Stanley, Park, Jung-Hyun, Singer, Alfred
Published in Cell cycle (Georgetown, Tex.) (01.03.2012)
Published in Cell cycle (Georgetown, Tex.) (01.03.2012)
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Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection
Yu, Qing, Park, Jung-Hyun, Doan, Loretta L, Erman, Batu, Feigenbaum, Lionel, Singer, Alfred
Published in The Journal of experimental medicine (23.01.2006)
Published in The Journal of experimental medicine (23.01.2006)
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Journal Article
Upregulation of CD4 Expression during MHC Class II-Specific Positive Selection Is Essential for Error-free Lineage Choice
Sarafova, Sophia D., Van Laethem, Francois, Adoro, Stanley, Guinter, Terry, Sharrow, Susan O., Feigenbaum, Lionel, Singer, Alfred
Published in Immunity (Cambridge, Mass.) (18.09.2009)
Published in Immunity (Cambridge, Mass.) (18.09.2009)
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Reversing T cell immunity reveals the basis for T cell lineage fate determination
Published in Nature immunology
(01.05.2022)
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