Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection
Brennan, Sean, Esposito, Simona, Abdelaziz, Muhammad I. M., Martin, Christopher A., Makwana, Samir, Sims, Mark W., Squire, Iain B., Sharma, Parveen, Chadwick, Amy E., Rainbow, Richard D.
Published in Frontiers in cardiovascular medicine (07.09.2022)
Published in Frontiers in cardiovascular medicine (07.09.2022)
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Identification and characterisation of functional Kir6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane
Brennan, Sean, Chen, Shen, Makwana, Samir, Esposito, Simona, McGuinness, Lauren R., Alnaimi, Abrar I. M., Sims, Mark W., Patel, Manish, Aziz, Qadeer, Ojake, Leona, Roberts, James A., Sharma, Parveen, Lodwick, David, Tinker, Andrew, Barrett‐Jolley, Richard, Dart, Caroline, Rainbow, Richard D.
Published in British journal of pharmacology (01.09.2024)
Published in British journal of pharmacology (01.09.2024)
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Journal Article
Identification and characterisation of functional K ir 6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane
Brennan, Sean, Chen, Shen, Makwana, Samir, Esposito, Simona, McGuinness, Lauren R, Alnaimi, Abrar I M, Sims, Mark W, Patel, Manish, Aziz, Qadeer, Ojake, Leona, Roberts, James A, Sharma, Parveen, Lodwick, David, Tinker, Andrew, Barrett-Jolley, Richard, Dart, Caroline, Rainbow, Richard D
Published in British journal of pharmacology (01.09.2024)
Published in British journal of pharmacology (01.09.2024)
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Journal Article
A novel form of glycolytic metabolism‐dependent cardioprotection revealed by PKCα and β inhibition
Brennan, Sean, Chen, Shen, Makwana, Samir, Martin, Christopher A., Sims, Mark W., Alonazi, Asma S.A., Willets, Jonathan M, Squire, Iain B., Rainbow, Richard D.
Published in The Journal of physiology (01.09.2019)
Published in The Journal of physiology (01.09.2019)
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Journal Article
Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection
Brennan, Sean, Jackson, Robert, Patel, Manish, Sims, Mark W, Hudman, Diane, Norman, Robert I, Lodwick, David, Rainbow, Richard D
Published in Journal of molecular and cellular cardiology (01.02.2015)
Published in Journal of molecular and cellular cardiology (01.02.2015)
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Journal Article
Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose
Jackson, Robert, Brennan, Sean, Fielding, Peter, Sims, Mark W, Challiss, RA John, Adlam, David, Squire, Iain B, Rainbow, Richard D
Published in British journal of pharmacology (01.03.2016)
Published in British journal of pharmacology (01.03.2016)
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Journal Article
PKC-mediated toxicity of elevated glucose concentration on cardiomyocyte function
Sims, Mark W, Winter, James, Brennan, Sean, Norman, Robert I, Ng, G André, Squire, Iain B, Rainbow, Richard D
Published in American journal of physiology. Heart and circulatory physiology (15.08.2014)
Published in American journal of physiology. Heart and circulatory physiology (15.08.2014)
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Journal Article
Distinct and complementary roles for [alpha] and [beta] isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose
Jackson, Robert, Brennan, Sean, Fielding, Peter, Sims, Mark W, Challiss, RA John, Adlam, David, Squire, Iain B, Rainbow, Richard D
Published in British journal of pharmacology (01.03.2016)
Published in British journal of pharmacology (01.03.2016)
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Journal Article