Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis
Yee, Nathan K, Farina, Vittorio, Houpis, Ioannis N, Haddad, Nizar, Frutos, Rogelio P, Gallou, Fabrice, Wang, Xiao-jun, Wei, Xudong, Simpson, Robert D, Feng, Xuwu, Fuchs, Victor, Xu, Yibo, Tan, Jonathan, Zhang, Li, Xu, Jinghua, Smith-Keenan, Lana L, Vitous, Jana, Ridges, Michael D, Spinelli, Earl M, Johnson, Michael, Donsbach, Kai, Nicola, Thomas, Brenner, Michael, Winter, Eric, Kreye, Paul, Samstag, Wendelin
Published in Journal of organic chemistry (15.09.2006)
Published in Journal of organic chemistry (15.09.2006)
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Journal Article
Optimization of orally bioavailable alkyl amine renin inhibitors
Xu, Zhenrong, Cacatian, Salvacion, Yuan, Jing, Simpson, Robert D., Jia, Lanqi, Zhao, Wei, Tice, Colin M., Flaherty, Patrick T., Guo, Joan, Ishchenko, Alexey, Singh, Suresh B., Wu, Zhongren, McKeever, Brian M., Scott, Boyd B., Bukhtiyarov, Yuri, Berbaum, Jennifer, Mason, Jennifer, Panemangalore, Reshma, Cappiello, Maria Grazia, Bentley, Ross, Doe, Christopher P., Harrison, Richard K., McGeehan, Gerard M., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility
Jia, Lanqi, Simpson, Robert D, Yuan, Jing, Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Tice, Colin M, Guo, Joan, Ishchenko, Alexey, Singh, Suresh B, Wu, Zhongren, McKeever, Brian M, Bukhtiyarov, Yuri, Johnson, Judith A, Doe, Christopher P, Harrison, Richard K, McGeehan, Gerard M, Dillard, Lawrence W, Baldwin, John J, Claremon, David A
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
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Journal Article
Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design
Tice, Colin M., Zhao, Wei, Xu, Zhenrong, Cacatian, Salvacion T., Simpson, Robert D., Ye, Yuan-Jie, Singh, Suresh B., McKeever, Brian M., Lindblom, Peter, Guo, Joan, Krosky, Paula M., Kruk, Barbara A., Berbaum, Jennifer, Harrison, Richard K., Johnson, Judith J., Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B., Zhao, Yi, Bruno, Joseph G., Zhuang, Linghang, McGeehan, Gerard M., He, Wei, Claremon, David A.
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Synthesis of a Novel Volatile Platinum Complex for Use in CVD and a Study of the Mechanism of Its Thermal Decomposition in Solution
Tagge, Christopher D, Simpson, Robert D, Bergman, Robert G, Hostetler, Michael J, Girolami, Gregory S, Nuzzo, Ralph G
Published in Journal of the American Chemical Society (20.03.1996)
Published in Journal of the American Chemical Society (20.03.1996)
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Journal Article
Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket
Yuan, Jing, Simpson, Robert D., Zhao, Wei, Tice, Colin M., Xu, Zhenrong, Cacatian, Salvacion, Jia, Lanqi, Flaherty, Patrick T., Guo, Joan, Ishchenko, Alexey, Wu, Zhongren, McKeever, Brian M., Scott, Boyd B., Bukhtiyarov, Yuri, Berbaum, Jennifer, Panemangalore, Reshma, Bentley, Ross, Doe, Christopher P., Harrison, Richard K., McGeehan, Gerard M., Singh, Suresh B., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
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Journal Article
Design and optimization of renin inhibitors: Orally bioavailable alkyl amines
Tice, Colin M., Xu, Zhenrong, Yuan, Jing, Simpson, Robert D., Cacatian, Salvacion T., Flaherty, Patrick T., Zhao, Wei, Guo, Joan, Ishchenko, Alexey, Singh, Suresh B., Wu, Zhongren, Scott, Boyd B., Bukhtiyarov, Yuri, Berbaum, Jennifer, Mason, Jennifer, Panemangalore, Reshma, Cappiello, Maria Grazia, Müller, Dominik, Harrison, Richard K., McGeehan, Gerard M., Dillard, Lawrence W., Baldwin, John J., Claremon, David A.
Published in Bioorganic & medicinal chemistry (01.07.2009)
Published in Bioorganic & medicinal chemistry (01.07.2009)
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Journal Article
Electronic Control of Chiral Quaternary Center Creation in the Intramolecular Asymmetric Heck Reaction
Busacca, Carl A, Grossbach, Danja, Campbell, Scot J, Dong, Yong, Eriksson, Magnus C, Harris, Robert E, Jones, Paul-James, Kim, Ji-Young, Lorenz, Jon C, McKellop, Keith B, O'Brien, Erin M, Qiu, Fenghe, Simpson, Robert D, Smith, Lana, So, Regina C, Spinelli, Earl M, Vitous, Jana, Zavattaro, Chiara
Published in Journal of organic chemistry (06.08.2004)
Published in Journal of organic chemistry (06.08.2004)
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Journal Article
Testing for adventitious presence of transgenic material in conventional seed or grain lots using quantitative laboratory methods: statistical procedures and their implementation
Laffont, Jean-Louis, Remund, Kirk M., Wright, Deanne, Simpson, Robert D., Grégoire, Sylvain
Published in Seed science research (01.09.2005)
Published in Seed science research (01.09.2005)
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Journal Article
Anionic Iridium Monohydrides
Simpson, Robert D, Marshall, William J, Farischon, Amy A, Roe, D. Christopher, Grushin, Vladimir V
Published in Inorganic chemistry (06.09.1999)
Published in Inorganic chemistry (06.09.1999)
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Journal Article
Carbon-carbon bond forming reactions of rhenium enolates with terminal alkynes. Evidence for an alkyne C-H oxidative addition mechanism and observation of highly stereoselective base-catalyzed proton transfer reactions in rhenium metallacycles
Stack, Jeffrey G, Simpson, Robert D, Hollander, Frederick J, Bergman, Robert G, Heathcock, Clayton H
Published in Journal of the American Chemical Society (01.03.1990)
Published in Journal of the American Chemical Society (01.03.1990)
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Journal Article
Spirocyclic ureas: Orally bioavailable 11b-HSD1 inhibitors identified by computer-aided drug design
Tice, Colin M, Zhao, Wei, Xu, Zhenrong, Cacatian, Salvacion T, Simpson, Robert D, Ye, Yuan-Jie, Singh, Suresh B, McKeever, Brian M, Lindblom, Peter, Guo, Joan, Krosky, Paula M, Kruk, Barbara A, Berbaum, Jennifer, Harrison, Richard K, Johnson, Judith J, Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B, Zhao, Yi, Bruno, Joseph G, Zhuang, Linghang, McGeehan, Gerard M, He, Wei, Claremon, David A
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article