Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice
Chen, Liyu, Simpson, Joshua D, Fuchs, Adrian V, Rolfe, Barbara E, Thurecht, Kristofer J
Published in Molecular pharmaceutics (04.12.2017)
Published in Molecular pharmaceutics (04.12.2017)
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Journal Article
Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus
Shang, Pengcheng, Simpson, Joshua D., Taylor, Gwen M., Sutherland, Danica M., Welsh, Olivia L., Aravamudhan, Pavithra, Natividade, Rita Dos Santos, Schwab, Kristina, Michel, Joshua J., Poholek, Amanda C., Wu, Yijen, Rajasundaram, Dhivyaa, Koehler, Melanie, Alsteens, David, Dermody, Terence S.
Published in Nature communications (05.05.2023)
Published in Nature communications (05.05.2023)
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Journal Article
Role of the Redox State of Human Peroxiredoxin-5 on Its TLR4-Activating DAMP Function
Poncin, Mégane A, Van Meerbeeck, Pierre, Simpson, Joshua D, Clippe, André, Tyckaert, François, Bouillenne, Fabrice, Degand, Hervé, Matagne, André, Morsomme, Pierre, Knoops, Bernard, Alsteens, David
Published in Antioxidants (27.11.2021)
Published in Antioxidants (27.11.2021)
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Single-Molecule Investigation of the Binding Interface Stability of SARS-CoV‑2 Variants with ACE2
Ray, Ankita, Minh Tran, Thu Thi, Santos Natividade, Rita dos, Moreira, Rodrigo A., Simpson, Joshua D., Mohammed, Danahe, Koehler, Melanie, L Petitjean, Simon J., Zhang, Qingrong, Bureau, Fabrice, Gillet, Laurent, Poma, Adolfo B., Alsteens, David
Published in ACS Nanoscience Au (17.04.2024)
Published in ACS Nanoscience Au (17.04.2024)
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Cyanine-5-Driven Behaviours of Hyperbranched Polymers Designed for Therapeutic Delivery Are Cell-Type Specific and Correlated with Polar Lipid Distribution in Membranes
Simpson, Joshua D., Currin-Ross, Denni L., Ediriweera, Gayathri R., Schirra, Horst Joachim, Fletcher, Nicholas L., Bell, Craig A., Arno, Maria C., Thurecht, Kristofer J.
Published in Nanomaterials (Basel, Switzerland) (02.07.2021)
Published in Nanomaterials (Basel, Switzerland) (02.07.2021)
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Journal Article
Atomic force microscopy applied to interrogate nanoscale cellular chemistry and supramolecular bond dynamics for biomedical applications
Simpson, Joshua D, Ray, Ankita, Koehler, Melanie, Mohammed, Danahe, Alsteens, David
Published in Chemical communications (Cambridge, England) (21.04.2022)
Published in Chemical communications (Cambridge, England) (21.04.2022)
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Journal Article
From viral assembly to host interaction: AFM's contributions to virology
Ray, Ankita, Simpson, Joshua D, Demir, Irem, Gisbert, Victor G, Gomes, David B, Amadei, Federico, Alsteens, David
Published in Journal of virology (10.12.2024)
Published in Journal of virology (10.12.2024)
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Journal Article
Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic
Pearce, Amanda K., Simpson, Joshua D., Fletcher, Nicholas L., Houston, Zachary H., Fuchs, Adrian V., Russell, Pamela J., Whittaker, Andrew K., Thurecht, Kristofer J.
Published in Biomaterials (01.10.2017)
Published in Biomaterials (01.10.2017)
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Journal Article
Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface
Simpson, Joshua D, Smith, Samuel A, Thurecht, Kristofer J, Such, Georgina
Published in Polymers (02.09.2019)
Published in Polymers (02.09.2019)
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Journal Article
Modulating Macrophage Clearance of Nanoparticles: Comparison of Small-Molecule and Biologic Drugs as Pharmacokinetic Modifiers of Soft Nanomaterials
Mills, Jessica A., Humphries, James, Simpson, Joshua D., Sonderegger, Stefan E., Thurecht, Kristofer J., Fletcher, Nicholas L.
Published in Molecular pharmaceutics (07.11.2022)
Published in Molecular pharmaceutics (07.11.2022)
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Journal Article
Using Peptide Aptamer Targeted Polymers as a Model Nanomedicine for Investigating Drug Distribution in Cancer Nanotheranostics
Zhao, Yongmei, Houston, Zachary H, Simpson, Joshua D, Chen, Liyu, Fletcher, Nicholas L, Fuchs, Adrian V, Blakey, Idriss, Thurecht, Kristofer J
Published in Molecular pharmaceutics (02.10.2017)
Published in Molecular pharmaceutics (02.10.2017)
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Journal Article
Deciphering molecular mechanisms stabilizing the reovirus-binding complex
Dos Santos Natividade, Rita, Koehler, Melanie, Gomes, Priscila S F C, Simpson, Joshua D, Smith, Sydni Caet, Gomes, Diego E B, de Lhoneux, Juliette, Yang, Jinsung, Ray, Ankita, Dermody, Terence S, Bernardi, Rafael C, Ogden, Kristen M, Alsteens, David
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2023)
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Journal Article
Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery
Ediriweera, Gayathri R, Simpson, Joshua D, Fuchs, Adrian V, Venkatachalam, Taracad K, Van De Walle, Matthias, Howard, Christopher B, Mahler, Stephen M, Blinco, James P, Fletcher, Nicholas L, Houston, Zachary H, Bell, Craig A, Thurecht, Kristofer J
Published in Chemical science (Cambridge) (28.03.2020)
Published in Chemical science (Cambridge) (28.03.2020)
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Journal Article
Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells
Simpson, Joshua D, Ediriweera, Gayathri R, Howard, Christopher B, Fletcher, Nicholas L, Bell, Craig A, Thurecht, Kristofer J
Published in Biomaterials science (01.11.2019)
Published in Biomaterials science (01.11.2019)
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Journal Article
Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies
Howard, Christopher B, Fletcher, Nicholas, Houston, Zachary H, Fuchs, Adrian V, Boase, Nathan R B, Simpson, Joshua D, Raftery, Lyndon J, Ruder, Tim, Jones, Martina L, de Bakker, Christopher J, Mahler, Stephen M, Thurecht, Kristofer J
Published in Advanced healthcare materials (01.08.2016)
Published in Advanced healthcare materials (01.08.2016)
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Journal Article
Fluorophore Selection and Incorporation Contribute to Permeation and Distribution Behaviors of Hyperbranched Polymers in Multi-Cellular Tumor Spheroids and Xenograft Tumor Models
Simpson, Joshua D, Monteiro, Patrícia F, Ediriweera, Gayathri R, Prior, Amber R, Sonderegger, Stefan E, Bell, Craig A, Fletcher, Nicholas L, Alexander, Cameron, Thurecht, Kristofer J
Published in ACS applied bio materials (15.03.2021)
Published in ACS applied bio materials (15.03.2021)
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Journal Article
Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy
Ediriweera, Gayathri R., Sivaram, Amal J., Cowin, Gary, Brown, Mikayla L., McAlary, Luke, Lum, Jeremy S., Fletcher, Nicholas L., Robinson, Liam, Simpson, Joshua D., Chen, Liyu, Wasielewska, Joanna M., Byrne, Ella, Finnie, John W., Manavis, Jim, White, Anthony R., Yerbury, Justin J., Thurecht, Kristofer J., Vine, Kara L.
Published in Journal of controlled release (10.02.2025)
Published in Journal of controlled release (10.02.2025)
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Journal Article
Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy
Ediriweera, Gayathri R, Sivaram, Amal J, Cowin, Gary, Brown, Mikayla L, McAlary, Luke, Lum, Jeremy S, Fletcher, Nicholas L, Robinson, Liam, Simpson, Joshua D, Chen, Liyu, Wasielewska, Joanna M, Byrne, Ella, Finnie, John W, Manavis, Jim, White, Anthony R, Yerbury, Justin J, Thurecht, Kristofer J, Vine, Kara L
Published in Journal of controlled release (12.12.2024)
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Published in Journal of controlled release (12.12.2024)
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