The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.
Published in Nature communications (11.05.2021)
Published in Nature communications (11.05.2021)
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Journal Article
Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response
Weerasinghe, Harshini, Simm, Claudia, Djajawi, Tirta Mario, Tedja, Irma, Lo, Tricia L., Simpson, Daniel S., Shasha, David, Mizrahi, Naama, Olivier, Françios A.B., Speir, Mary, Lawlor, Kate E., Ben-Ami, Ronen, Traven, Ana
Published in Cell reports (Cambridge) (30.05.2023)
Published in Cell reports (Cambridge) (30.05.2023)
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Journal Article
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
Grohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S., Dong, Hao, Dorizzi, Bridget, Jacobsen, Annette V., Morrish, Emma, Silke, Natasha, Murphy, James M., Heath, Joan K., Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Lessene, Guillaume, Silke, John, Feltham, Rebecca
Published in Nature communications (19.04.2022)
Published in Nature communications (19.04.2022)
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Journal Article
RIPK1 ubiquitination: Evidence, correlations and the undefined
Simpson, Daniel S., Gabrielyan, Anna, Feltham, Rebecca
Published in Seminars in cell & developmental biology (01.01.2021)
Published in Seminars in cell & developmental biology (01.01.2021)
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Journal Article
Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation
Yabal, Monica, Calleja, Dale J., Simpson, Daniel S., Lawlor, Kate E.
Published in Journal of leukocyte biology (01.02.2019)
Published in Journal of leukocyte biology (01.02.2019)
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Journal Article
Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis
Sharma, Arpeeta, Choi, Judy S Y, Stefanovic, Nada, Al-Sharea, Annas, Simpson, Daniel S, Mukhamedova, Nigora, Jandeleit-Dahm, Karin, Murphy, Andrew J, Sviridov, Dmitri, Vince, James E, Ritchie, Rebecca H, de Haan, Judy B
Published in Diabetes (New York, N.Y.) (01.03.2021)
Published in Diabetes (New York, N.Y.) (01.03.2021)
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Journal Article
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release
Rashidi, Maryam, Simpson, Daniel S, Hempel, Anne, Frank, Daniel, Petrie, Emma, Vince, Angelina, Feltham, Rebecca, Murphy, Jane, Chatfield, Simon M, Salvesen, Guy S, Murphy, James M, Wicks, Ian P, Vince, James E
Published in The Journal of immunology (1950) (01.08.2019)
Published in The Journal of immunology (1950) (01.08.2019)
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Journal Article
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Simpson, Daniel S., Pang, Jiyi, Weir, Ashley, Kong, Isabella Y., Fritsch, Melanie, Rashidi, Maryam, Cooney, James P., Davidson, Kathryn C., Speir, Mary, Djajawi, Tirta M., Hughes, Sebastian, Mackiewicz, Liana, Dayton, Merle, Anderton, Holly, Doerflinger, Marcel, Deng, Yexuan, Huang, Allan Shuai, Conos, Stephanie A., Tye, Hazel, Chow, Seong H., Rahman, Arfatur, Norton, Raymond S., Naderer, Thomas, Nicholson, Sandra E., Burgio, Gaetan, Man, Si Ming, Groom, Joanna R., Herold, Marco J., Hawkins, Edwin D., Lawlor, Kate E., Strasser, Andreas, Silke, John, Pellegrini, Marc, Kashkar, Hamid, Feltham, Rebecca, Vince, James E.
Published in Immunity (Cambridge, Mass.) (08.03.2022)
Published in Immunity (Cambridge, Mass.) (08.03.2022)
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Journal Article
Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development
Anderton, Holly, Bandala-Sanchez, Esther, Simpson, Daniel S., Rickard, James A., Ng, Ashley P., Di Rago, Ladina, Hall, Cathrine, Vince, James E., Silke, John, Liccardi, Gianmaria, Feltham, Rebecca
Published in Cell death and differentiation (07.11.2024)
Published in Cell death and differentiation (07.11.2024)
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Journal Article
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development
Anderton, Holly, Bandala-Sanchez, Esther, Simpson, Daniel S, Rickard, James A, Ng, Ashley P, Di Rago, Ladina, Hall, Cathrine, Vince, James E, Silke, John, Liccardi, Gianmaria, Feltham, Rebecca
Published in Cell death and differentiation (01.05.2019)
Published in Cell death and differentiation (01.05.2019)
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Journal Article
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells
Wang, Zilu, Burigotto, Matteo, Ghetti, Sabrina, Vaillant, François, Tan, Tao, Capaldo, Bianca D, Palmieri, Michelle, Hirokawa, Yumiko, Tai, Lin, Simpson, Daniel S, Chang, Catherine, Huang, Allan Shuai, Lieschke, Elizabeth, Diepstraten, Sarah T, Kaloni, Deeksha, Riffkin, Chris, Huang, David C S, Li Wai Suen, Connie S N, Garnham, Alexandra L, Gibbs, Peter, Visvader, Jane E, Sieber, Oliver M, Herold, Marco J, Fava, Luca L, Kelly, Gemma L, Strasser, Andreas
Published in Cancer discovery (08.02.2024)
Published in Cancer discovery (08.02.2024)
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Journal Article
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency
Hughes, Sebastian A, Lin, Meng, Weir, Ashley, Huang, Bing, Xiong, Liya, Chua, Ngee Kiat, Pang, Jiyi, Santavanond, Jascinta P, Tixeira, Rochelle, Doerflinger, Marcel, Deng, Yexuan, Yu, Chien‐Hsiung, Silke, Natasha, Conos, Stephanie A, Frank, Daniel, Simpson, Daniel S, Murphy, James M, Lawlor, Kate E, Pearson, Jaclyn S, Silke, John, Pellegrini, Marc, Herold, Marco J, Poon, Ivan K H, Masters, Seth L, Li, Mingsong, Tang, Qin, Zhang, Yuxia, Rashidi, Maryam, Geng, Lanlan, Vince, James E
Published in The EMBO journal (01.03.2023)
Published in The EMBO journal (01.03.2023)
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Journal Article
A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation
Speir, Mary, Tye, Hazel, Gottschalk, Timothy A, Simpson, Daniel S, Djajawi, Tirta M, Deo, Pankaj, Ambrose, Rebecca L, Conos, Stephanie A, Emery, Jack, Abraham, Gilu, Pascoe, Ashlyn, Hughes, Sebastian A, Weir, Ashley, Hawkins, Edwin D, Kong, Isabella, Herold, Marco J, Pearson, Jaclyn S, Lalaoui, Najoua, Naderer, Thomas, Vince, James E, Lawlor, Kate E
Published in EMBO reports (06.11.2023)
Published in EMBO reports (06.11.2023)
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Journal Article
The Australasian Cell Death Society (ACDS): celebrating 50 years of Australasian cell death research
Speir, Mary, Chan, Amy H, Simpson, Daniel S, Khan, Tashbib, Saunders, Tahnee L, Poon, Ivan Kh, Atkin-Smith, Georgia K
Published in Immunology and cell biology (01.01.2022)
Published in Immunology and cell biology (01.01.2022)
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Journal Article
Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death
Simpson, Daniel S, Anderton, Holly, Yousef, Jumana, Vaibhav, Vineet, Cobbold, Simon A, Bandala-Sanchez, Esther, Kueh, Andrew J, Dagley, Laura F, Herold, Marco J, Silke, John, Vince, James E, Feltham, Rebecca
Published in PNAS nexus (01.01.2024)
Published in PNAS nexus (01.01.2024)
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Journal Article
Divergent roles of RIPK3 and MLKL in high-fat diet-induced obesity and MAFLD in mice
Tye, Hazel, Conos, Stephanie A, Djajawi, Tirta M, Gottschalk, Timothy A, Abdoulkader, Nasteho, Kong, Isabella Y, Kammoun, Helene L, Narayana, Vinod K, Kratina, Tobias, Speir, Mary, Emery, Jack, Simpson, Daniel S, Hall, Cathrine, Vince, Angelina J, Russo, Sophia, Crawley, Rhiannan, Rashidi, Maryam, Hildebrand, Joanne M, Murphy, James M, Whitehead, Lachlan, De Souza, David P, Masters, Seth L, Samson, Andre L, Lalaoui, Najoua, Hawkins, Edwin D, Murphy, Andrew J, Vince, James E, Lawlor, Kate E
Published in Life science alliance (01.01.2025)
Published in Life science alliance (01.01.2025)
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Journal Article
The inflammasome-activated cytokine IL-1β is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential
Vijayaraj, Swarna L, Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S, Ebert, Gregor, Vince, Angelina, Herold, Marco J, Kueh, Andrew, Pearson, Jaclyn S, Dagley, Laura F, Murphy, James M, Webb, Andrew I, Lawlor, Kate E, Vince, James E
Published in bioRxiv (16.03.2021)
Published in bioRxiv (16.03.2021)
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Paper
Utilization of Advanced Imaging Technologies for Target Delineation in Radiation Oncology
Simpson, Daniel R., BS, Lawson, Joshua D., MD, Nath, Sameer K., BA, Rose, Brent S., BS, Mundt, Arno J., MD, Mell, Loren K., MD
Published in Journal of the American College of Radiology (01.12.2009)
Published in Journal of the American College of Radiology (01.12.2009)
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Journal Article