Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology
Izco, María, Blesa, Javier, Schleef, Martin, Schmeer, Marco, Porcari, Riccardo, Al-Shawi, Raya, Ellmerich, Stephan, de Toro, María, Gardiner, Chris, Seow, Yiqi, Reinares-Sebastian, Alejandro, Forcen, Raquel, Simons, J. Paul, Bellotti, Vittorio, Cooper, J. Mark, Alvarez-Erviti, Lydia
Published in Molecular therapy (04.12.2019)
Published in Molecular therapy (04.12.2019)
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Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway
Killick, R, Ribe, E M, Al-Shawi, R, Malik, B, Hooper, C, Fernandes, C, Dobson, R, Nolan, P M, Lourdusamy, A, Furney, S, Lin, K, Breen, G, Wroe, R, To, A W M, Leroy, K, Causevic, M, Usardi, A, Robinson, M, Noble, W, Williamson, R, Lunnon, K, Kellie, S, Reynolds, C H, Bazenet, C, Hodges, A, Brion, J-P, Stephenson, J, Simons, J Paul, Lovestone, Simon
Published in Molecular psychiatry (01.01.2014)
Published in Molecular psychiatry (01.01.2014)
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Journal Article
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis
Slamova, Ivana, Adib, Rozita, Ellmerich, Stephan, Golos, Michal R, Gilbertson, Janet A, Botcher, Nicola, Canetti, Diana, Taylor, Graham W, Rendell, Nigel, Tennent, Glenys A, Verona, Guglielmo, Porcari, Riccardo, Mangione, P Patrizia, Gillmore, Julian D, Pepys, Mark B, Bellotti, Vittorio, Hawkins, Philip N, Al-Shawi, Raya, Simons, J Paul
Published in Nature communications (07.12.2021)
Published in Nature communications (07.12.2021)
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Journal Article
Pathogenetic mechanisms of amyloid A amyloidosis
Simons, J. Paul, Al-Shawib, Raya, Ellmerich, Stephan, Speck, Ivana, Aslam, Samrina, Hutchinson, Winston L., Mangione, Palma P., Disterer, Petra, Gilbertson, Janet A., Hunt, Toby, Millar, David J., Minogue, Shane, Bodin, Karl, Pepys, Mark B., Hawkins, Philip N.
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2013)
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Journal Article
C‐reactive protein is essential for innate resistance to pneumococcal infection
Paul Simons, J., Loeffler, Jutta M., Al‐Shawi, Raya, Ellmerich, Stephan, Hutchinson, Winston L., Tennent, Glenys A., Petrie, Aviva, Raynes, John G., Souza, J. Brian, Lawrence, Rachel A., Read, Kevin D., Pepys, Mark B.
Published in Immunology (01.07.2014)
Published in Immunology (01.07.2014)
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Journal Article
Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al-Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El-Andaloussi, Samir, Alvarez-Erviti, Lydia
Published in Movement disorders (01.10.2014)
Published in Movement disorders (01.10.2014)
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Journal Article
Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells
Lopes da Silva, Mafalda, O'Connor, Marie N, Kriston-Vizi, Janos, White, Ian J, Al-Shawi, Raya, Simons, J Paul, Mössinger, Julia, Haucke, Volker, Cutler, Daniel F
Published in Journal of cell science (15.05.2016)
Published in Journal of cell science (15.05.2016)
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Journal Article
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo
Raimondi, Sara, Porcari, Riccardo, Mangione, P. Patrizia, Verona, Guglielmo, Marcoux, Julien, Giorgetti, Sofia, Taylor, Graham W., Ellmerich, Stephan, Ballico, Maurizio, Zanini, Stefano, Pardon, Els, Al-Shawi, Raya, Simons, J. Paul, Corazza, Alessandra, Fogolari, Federico, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, Julian D., Hawkins, Philip N., Valli, Maurizia, Stoppini, Monica, Robinson, Carol V., Steyaert, Jan, Esposito, Gennaro, Bellotti, Vittorio
Published in Scientific reports (21.04.2017)
Published in Scientific reports (21.04.2017)
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Journal Article
Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity
Kimura, Atsuko, Stevenson, Paula L., Carter, Roderick N., MacColl, Gavin, French, Karen L., Paul Simons, J., Al-Shawi, Raya, Kelly, Valerie, Chapman, Karen E., Holmes, Megan C.
Published in The European journal of neuroscience (01.07.2009)
Published in The European journal of neuroscience (01.07.2009)
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Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β2-Microglobulin
Halabelian, Levon, Ricagno, Stefano, Giorgetti, Sofia, Santambrogio, Carlo, Barbiroli, Alberto, Pellegrino, Sara, Achour, Adnane, Grandori, Rita, Marchese, Loredana, Raimondi, Sara, Mangione, P. Patrizia, Esposito, Gennaro, Al-Shawi, Raya, Simons, J. Paul, Speck, Ivana, Stoppini, Monica, Bolognesi, Martino, Bellotti, Vittorio
Published in The Journal of biological chemistry (07.02.2014)
Published in The Journal of biological chemistry (07.02.2014)
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Journal Article
Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo
Al-Shawi, Raya, Tennent, Glenys A., Millar, David J., Richard-Londt, Angela, Brandner, Sebastian, Werring, David J., Simons, J. Paul, Pepys, Mark B.
Published in Open biology (01.02.2016)
Published in Open biology (01.02.2016)
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Oligonucleotide-mediated gene editing is underestimated in cells expressing mutated green fluorescent protein and is positively associated with target protein expression
Disterer, Petra, Papaioannou, Ioannis, Evans, Vanessa C., Paul Simons, J., Owen, James S.
Published in The journal of gene medicine (01.02.2012)
Published in The journal of gene medicine (01.02.2012)
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Journal Article
Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice
Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al‐Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El‐Andaloussi, Samir, Alvarez‐Erviti, Lydia
Published in Movement disorders (01.10.2014)
Published in Movement disorders (01.10.2014)
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Journal Article
Antibody-Associated Reversal of ATTR Amyloidosis–Related Cardiomyopathy
Fontana, Marianna, Gilbertson, Janet, Verona, Guglielmo, Riefolo, Mattia, Slamova, Ivana, Leone, Ornella, Rowczenio, Dorota, Botcher, Nicola, Ioannou, Adam, Patel, Rishi K., Razvi, Yousuf, Martinez-Naharro, Ana, Whelan, Carol J., Venneri, Lucia, Duhlin, Amanda, Canetti, Diana, Ellmerich, Stephan, Moon, James C., Kellman, Peter, Al-Shawi, Raya, McCoy, Laura, Simons, J. Paul, Hawkins, Philip N., Gillmore, Julian D.
Published in The New England journal of medicine (08.06.2023)
Published in The New England journal of medicine (08.06.2023)
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Journal Article
Reducing β-Amyloid by Inhibition of BACE1 : How Low Should You Go?
Killick, Richard, Hardy, John, Simons, J. Paul
Published in Biological psychiatry (1969) (15.04.2015)
Published in Biological psychiatry (1969) (15.04.2015)
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Novel defect in phosphatidylinositol 4‐kinase type 2‐alpha (PI4K2A) at the membrane‐enzyme interface is associated with metabolic cutis laxa
Mohamed, Miski, Gardeitchik, Thatjana, Balasubramaniam, Shanti, Guerrero‐Castillo, Sergio, Dalloyaux, Daisy, Kraaij, Sanne, Venselaar, Hanka, Hoischen, Alexander, Urban, Zsolt, Brandt, Ulrich, Al‐Shawi, Raya, Simons, J. Paul, Frison, Michele, Ngu, Lock‐Hock, Callewaert, Bert, Spelbrink, Hans, Kallemeijn, Wouter W., Aerts, Johannes M. F. G., Waugh, Mark G., Morava, Eva, Wevers, Ron A.
Published in Journal of inherited metabolic disease (01.11.2020)
Published in Journal of inherited metabolic disease (01.11.2020)
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Journal Article
Exon Skipping of Hepatic APOB Pre-mRNA With Splice-switching Oligonucleotides Reduces LDL Cholesterol In Vivo
Disterer, Petra, Al-Shawi, Raya, Ellmerich, Stephan, Waddington, Simon N, Owen, James S, Simons, J Paul, Khoo, Bernard
Published in Molecular therapy (01.03.2013)
Published in Molecular therapy (01.03.2013)
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Oligonucleotide-directed gene-editing technology: mechanisms and future prospects
Papaioannou, Ioannis, Simons, J Paul, Owen, James S
Published in Expert opinion on biological therapy (01.03.2012)
Published in Expert opinion on biological therapy (01.03.2012)
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