Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
Lacey, David L., Boyle, William J., Simonet, W. Scott, Kostenuik, Paul J., Dougall, William C., Sullivan, John K., Martin, Javier San, Dansey, Roger
Published in Nature reviews. Drug discovery (01.05.2012)
Published in Nature reviews. Drug discovery (01.05.2012)
Get full text
Journal Article
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
Zhou, Xiaolan, Wang, Jin Lin, Lu, John, Song, Yanping, Kwak, Keith S., Jiao, Qingsheng, Rosenfeld, Robert, Chen, Qing, Boone, Thomas, Simonet, W. Scott, Lacey, David L., Goldberg, Alfred L., Han, H.Q.
Published in Cell (20.08.2010)
Published in Cell (20.08.2010)
Get full text
Journal Article
Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis
Li, Xiaodong, Ominsky, Michael S, Warmington, Kelly S, Morony, Sean, Gong, Jianhua, Cao, Jin, Gao, Yongming, Shalhoub, Victoria, Tipton, Barbara, Haldankar, Raj, Chen, Qing, Winters, Aaron, Boone, Tom, Geng, Zhaopo, Niu, Qing‐Tian, Ke, Hua Zhu, Kostenuik, Paul J, Simonet, W Scott, Lacey, David L, Paszty, Chris
Published in Journal of bone and mineral research (01.04.2009)
Published in Journal of bone and mineral research (01.04.2009)
Get full text
Journal Article
Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength
Ominsky, Michael S, Vlasseros, Fay, Jolette, Jacquelin, Smith, Susan Y, Stouch, Brian, Doellgast, George, Gong, Jianhua, Gao, Yongming, Cao, Jin, Graham, Kevin, Tipton, Barbara, Cai, Jill, Deshpande, Rohini, Zhou, Lei, Hale, Michael D, Lightwood, Daniel J, Henry, Alistair J, Popplewell, Andrew G, Moore, Adrian R, Robinson, Martyn K, Lacey, David L, Simonet, W Scott, Paszty, Chris
Published in Journal of bone and mineral research (01.05.2010)
Published in Journal of bone and mineral research (01.05.2010)
Get full text
Journal Article
Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
Li, Xiaodong, Ominsky, Michael S, Niu, Qing‐Tian, Sun, Ning, Daugherty, Betsy, D'Agostin, Diane, Kurahara, Carole, Gao, Yongming, Cao, Jin, Gong, Jianhua, Asuncion, Frank, Barrero, Mauricio, Warmington, Kelly, Dwyer, Denise, Stolina, Marina, Morony, Sean, Sarosi, Ildiko, Kostenuik, Paul J, Lacey, David L, Simonet, W Scott, Ke, Hua Zhu, Paszty, Chris
Published in Journal of bone and mineral research (01.06.2008)
Published in Journal of bone and mineral research (01.06.2008)
Get full text
Journal Article
Sclerostin Antibody Reverses Bone Loss by Increasing Bone Formation and Decreasing Bone Resorption in a Rat Model of Male Osteoporosis
Li, Xiaodong, Ominsky, Michael S, Villasenor, Kelly S, Niu, Qing-Tian, Asuncion, Frank J, Xia, Xuechun, Grisanti, Mario, Wronski, Thomas J, Simonet, W Scott, Ke, Hua Zhu
Published in Endocrinology (Philadelphia) (01.01.2018)
Published in Endocrinology (Philadelphia) (01.01.2018)
Get full text
Journal Article
Inhibition of WISE Preserves Renal Allograft Function
XUEMING QIAN, XIAODONG YUAN, VALENTE, Eliane G, PRETORIUS, Jim, STENVENS, Jennitte L, TIPTON, Barbara, WINTERS, Aaron G, GRAHAM, Kevin, HARRISS, Lindsey, BAKER, Daniel M, DAMORE, Michael, SALIMI-MOOSAVI, Hossein, VONDERFECHT, Steven, YONGMING GAO, ELKHAL, Abdallah, PASZTY, Chris, SCOTT SIMONET, W, RICHARDS, William G, TULLIUS, Stefan G, XUPENG GE, LEE, Jae, JURISCH, Anke, LI ZHANG, YOU, Andrew, FITZPATRICK, Vincent D, WILLIAM, Alexia
Published in Journal of the American Society of Nephrology (01.01.2013)
Published in Journal of the American Society of Nephrology (01.01.2013)
Get full text
Journal Article
Novel Neurotrophin-1/B Cell-Stimulating Factor-3: A Cytokine of the IL-6 Family
Senaldi, G, Varnum, B C, Sarmiento, U, Starnes, C, Lile, J, Scully, S, Guo, J, Elliott, G, McNinch, J, Shaklee, C L, Freeman, D, Manu, F, Simonet, W S, Boone, T, Chang, M S
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.1999)
Get full text
Journal Article
Dickkopf‐1 regulates bone formation in young growing rodents and upon traumatic injury
Li, Xiaodong, Grisanti, Mario, Fan, Wei, Asuncion, Frank J, Tan, Hong‐Lin, Dwyer, Denise, Han, Chun‐Ya, Yu, Longchuan, Lee, Jae, Lee, Edward, Barrero, Mauricio, Kurimoto, Pam, Niu, Qing‐Tian, Geng, Zhaopo, Winters, Aaron, Horan, Tom, Steavenson, Shirley, Jacobsen, Frederick, Chen, Qing, Haldankar, Raj, Lavallee, Jennifer, Tipton, Barbara, Daris, Mark, Sheng, Jackie, Lu, Hsieng S, Daris, Kristi, Deshpande, Rohini, Valente, Eliane G, Salimi‐Moosavi, Hossein, Kostenuik, Paul J, Li, Ji, Liu, Min, Li, Chaoyang, Lacey, David L, Simonet, W Scott, Ke, Hua Zhu, Babij, Philip, Stolina, Marina, Ominsky, Michael S, Richards, William G
Published in Journal of bone and mineral research (01.11.2011)
Published in Journal of bone and mineral research (01.11.2011)
Get full text
Journal Article
Idiopathic Hyperphosphatasia and TNFRSF11B Mutations: Relationships Between Phenotype and Genotype
Chong, Belinda, Hegde, Madhuri, Fawkner, Matthew, Simonet, Scott, Cassinelli, Hamilton, Coker, Mahmut, Kanis, John, Seidel, Joerg, Tau, Cristina, Tüysüz, Beyhan, Yüksel, Bilgin, Love, Donald, Cundy, Tim
Published in Journal of bone and mineral research (01.12.2003)
Published in Journal of bone and mineral research (01.12.2003)
Get full text
Journal Article
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis
Min, H, Morony, S, Sarosi, I, Dunstan, C R, Capparelli, C, Scully, S, Van, G, Kaufman, S, Kostenuik, P J, Lacey, D L, Boyle, W J, Simonet, W S
Published in The Journal of experimental medicine (21.08.2000)
Published in The Journal of experimental medicine (21.08.2000)
Get full text
Journal Article
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
Min, H, Danilenko, D M, Scully, S A, Bolon, B, Ring, B D, Tarpley, J E, DeRose, M, Simonet, W S
Published in Genes & development (15.10.1998)
Published in Genes & development (15.10.1998)
Get full text
Journal Article
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
Li, Ji, Sarosi, Ildiko, Cattley, Russell C., Pretorius, James, Asuncion, Frank, Grisanti, Mario, Morony, Sean, Adamu, Stephen, Geng, Zhaopo, Qiu, Wanrong, Kostenuik, Paul, Lacey, David L., Simonet, W. Scott, Bolon, Brad, Qian, Xueming, Shalhoub, Victoria, Ominsky, Michael S., Zhu Ke, Hua, Li, Xiaodong, Richards, William G.
Published in Bone (New York, N.Y.) (01.10.2006)
Published in Bone (New York, N.Y.) (01.10.2006)
Get full text
Journal Article
Pulmonary Malformation in Transgenic Mice Expressing Human Keratinocyte Growth Factor in the Lung
Simonet, W S, DeRose, M L, Bucay, N, Nguyen, H Q, Wert, S E, Zhou, L, Ulich, T R, Thomason, A, Danilenko, D M, Whitsett, J A
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.1995)
Get full text
Journal Article
The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction
Bolon, Brad, Jing, Shuqian, Asuncion, Frank, Scully, Sheila, Pisegna, Marlese, Van, Gwyneth Y, Hu, Zheng, Yu, Yan Bin, Min, Hosung, Wild, Ken, Rosenfeld, Robert D, Tarpley, John, Carnahan, Josette, Duryea, Diane, Hill, Dave, Kaufman, Steve, Yan, Xiao-Qiang, Juan, Todd, Christensen, Kathy, McCabe, James, Simonet, W Scott
Published in Toxicologic pathology (01.05.2004)
Published in Toxicologic pathology (01.05.2004)
Get more information
Journal Article
Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin
Li, Xiaodong, Ominsky, Michael S, Stolina, Marina, Warmington, Kelly S, Geng, Zhaopo, Niu, Qing-Tian, Asuncion, Frank J, Tan, Hong-Lin, Grisanti, Mario, Dwyer, Denise, Adamu, Steven, Ke, Hua Zhu, Simonet, W. Scott, Kostenuik, Paul J
Published in Bone (New York, N.Y.) (01.10.2009)
Published in Bone (New York, N.Y.) (01.10.2009)
Get full text
Journal Article
FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation
Hu, Mickey C.-T., Qiu, Wan R., Wang, You-ping, Hill, Dave, Ring, Brian D., Scully, Sheila, Bolon, Brad, DeRose, Margaret, Luethy, Roland, Simonet, W. Scott, Arakawa, Tsutomu, Danilenko, Dimitry M.
Published in Molecular and Cellular Biology (01.10.1998)
Published in Molecular and Cellular Biology (01.10.1998)
Get full text
Journal Article
Keratinocyte growth factor reduces lung damage due to acid instillation in rats
Yano, T, Deterding, RR, Simonet, WS, Shannon, JM, Mason, RJ
Published in American journal of respiratory cell and molecular biology (01.10.1996)
Published in American journal of respiratory cell and molecular biology (01.10.1996)
Get full text
Journal Article