Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease
Hallett, Penelope J, Engelender, Simone, Isacson, Ole
Published in Journal of neuroinflammation (22.07.2019)
Published in Journal of neuroinflammation (22.07.2019)
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Journal Article
The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway
Szargel, Raymonde, Shani, Vered, Abd Elghani, Fatimah, Mekies, Lucy N, Liani, Esti, Rott, Ruth, Engelender, Simone
Published in Human molecular genetics (15.08.2016)
Published in Human molecular genetics (15.08.2016)
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Journal Article
Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion
Hao, Tianshu, Yu, Jianglong, Wu, Zhida, Jiang, Jie, Gong, Longlong, Wang, Bingjun, Guo, Hanze, Zhao, Huabin, Lu, Bin, Engelender, Simone, He, He, Song, Zhiyin
Published in Nature communications (11.07.2023)
Published in Nature communications (11.07.2023)
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Journal Article
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease
Dong, Jun, Chen, Li, Ye, Fei, Tang, Junhui, Liu, Bing, Lin, Jiacheng, Zhou, Pang-Hu, Lu, Bin, Wu, Min, Lu, Jia-Hong, He, Jing-Jing, Engelender, Simone, Meng, Qingtao, Song, Zhiyin, He, He
Published in Nature communications (02.01.2024)
Published in Nature communications (02.01.2024)
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Journal Article
Physiological and pathological roles of LRRK2 in the nuclear envelope integrity
Shani, Vered, Safory, Hazem, Szargel, Raymonde, Wang, Ninghan, Cohen, Tsipora, Elghani, Fatimah Abd, Hamza, Haya, Savyon, Mor, Radzishevsky, Inna, Shaulov, Lihi, Rott, Ruth, Lim, Kah-Leong, Ross, Christopher A, Bandopadhyay, Rina, Zhang, Hui, Engelender, Simone
Published in Human molecular genetics (01.12.2019)
Published in Human molecular genetics (01.12.2019)
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Journal Article
Phosphorylation of Parkin by the Cyclin-dependent Kinase 5 at the Linker Region Modulates Its Ubiquitin-Ligase Activity and Aggregation
Avraham, Eyal, Rott, Ruth, Liani, Esti, Szargel, Raymonde, Engelender, Simone
Published in The Journal of biological chemistry (27.04.2007)
Published in The Journal of biological chemistry (27.04.2007)
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Journal Article
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1
Nucifora, Jr, Frederick C, Nucifora, Leslie G, Ng, Chee-Hoe, Arbez, Nicolas, Guo, Yajuan, Roby, Elaine, Shani, Vered, Engelender, Simone, Wei, Dong, Wang, Xiao-Fang, Li, Tianxia, Moore, Darren J, Pletnikova, Olga, Troncoso, Juan C, Sawa, Akira, Dawson, Ted M, Smith, Wanli, Lim, Kah-Leong, Ross, Christopher A
Published in Nature communications (07.06.2016)
Published in Nature communications (07.06.2016)
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Journal Article
The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission
Safory, Hazem, Neame, Samah, Shulman, Yoav, Zubedat, Salman, Radzishevsky, Inna, Rosenberg, Dina, Sason, Hagit, Engelender, Simone, Avital, Avi, Hülsmann, Swen, Schiller, Jackie, Wolosker, Herman
Published in EMBO reports (01.05.2015)
Published in EMBO reports (01.05.2015)
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Journal Article
Parkin Mediates Nonclassical, Proteasomal-Independent Ubiquitination of Synphilin-1: Implications for Lewy Body Formation
Lim, Kah Leong, Chew, Katherine C. M, Tan, Jeanne M. M, Wang, Cheng, Chung, Kenny K. K, Zhang, Yi, Tanaka, Yuji, Smith, Wanli, Engelender, Simone, Ross, Christopher A, Dawson, Valina L, Dawson, Ted M
Published in The Journal of neuroscience (23.02.2005)
Published in The Journal of neuroscience (23.02.2005)
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Journal Article
AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease
Basil, Adeline H, Sim, Joan P L, Lim, Grace G Y, Lin, Shuping, Chan, Hui Ying, Engelender, Simone, Lim, Kah-Leong
Published in Frontiers in cellular neuroscience (10.08.2017)
Published in Frontiers in cellular neuroscience (10.08.2017)
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Journal Article
Ubiquitylation of Synphilin-1 and α-Synuclein by SIAH and Its Presence in Cellular Inclusions and Lewy Bodies Imply a Role in Parkinson's Disease
Liani, Esti, Eyal, Allon, Avraham, Eyal, Shemer, Revital, Szargel, Raymonde, Berg, Daniela, Bornemann, Antje, Riess, Olaf, Ross, Christopher A., Rott, Ruth, Engelender, Simone, Hershko, Avram
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (13.04.2004)
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Journal Article
Human serine racemase: moleular cloning, genomic organization and functional analysis
De Miranda, Joari, Santoro, Ana, Engelender, Simone, Wolosker, Herman
Published in Gene (03.10.2000)
Published in Gene (03.10.2000)
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Journal Article
Synphilin-1A: An Aggregation-Prone Isoform of Synphilin-1 That Causes Neuronal Death and Is Present in Aggregates from α-Synucleinopathy Patients
Eyal, Allon, Szargel, Raymonde, Avraham, Eyal, Liani, Esti, Haskin, Joseph, Rott, Ruth, Engelender, Simone
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.2006)
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Journal Article
proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease
Marx, Frank P, Soehn, Anne S, Berg, Daniela, Melle, Christian, Schiesling, Carola, Lang, Mira, Kautzmann, Sabine, Strauss, Karsten M, Franck, Thomas, Engelender, Simone, Pahnke, Jens, Dawson, Simon, von Eggeling, Ferdinand, Schulz, Jörg B, Riess, Olaf, Krüger, Rejko
Published in The FASEB journal (01.06.2007)
Published in The FASEB journal (01.06.2007)
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Journal Article
A New Strategy to Decrease N-Methyl-D-Aspartate (NMDA) Receptor Coactivation: Inhibition of D-Serine Synthesis by Converting Serine Racemase into an Eliminase
Panizzutti, Rogério, De Miranda, Joari, Ribeiro, Cátia S., Engelender, Simone, Wolosker, Herman
Published in Proceedings of the National Academy of Sciences - PNAS (24.04.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (24.04.2001)
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