Structure-based approaches to drug discovery against tuberculosis
Holton, Simon J, Weiss, Manfred S, Tucker, Paul A, Wilmanns, Matthias
Published in Current protein & peptide science (01.08.2007)
Published in Current protein & peptide science (01.08.2007)
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Journal Article
Surface-mutagenesis strategies to enable structural biology crystallization platforms
Schaefer, Martina, Pütter, Vera, Hilpmann, André, Egner, Ursula, Holton, Simon James, Hillig, Roman Christian
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2024)
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2024)
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Journal Article
Expression, purification, crystallization and preliminary crystallographic analysis of the mouse transcription factor MafB in complex with its DNA-recognition motif Cmare
Textor, Larissa C., Wilmanns, Matthias, Holton, Simon J.
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.08.2007)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.08.2007)
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Journal Article
Structure of Mesorhizobium loti arylamine N-acetyltransferase 1
Holton, Simon J., Dairou, Julien, Sandy, James, Rodrigues-Lima, Fernando, Dupret, Jean-Marie, Noble, Martin E. M., Sim, Edith
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.01.2005)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.01.2005)
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Journal Article
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroi-sophthalamides as covalent PPARG inverse-agonists
Orsi, Douglas L., Ferrara, Steven J., Siegel, Stephan, Friberg, Anders, Bouche, Lea, Pook, Elisabeth, Lienau, Philip, Bluck, Joseph P., Lemke, Christopher T., Akcay, Gizem, Stellfeld, Timo, Meyer, Hanna, Puetter, Vera, Holton, Simon J., Korr, Daniel, Jerchel-Furau, Isabel, Pantelidou, Constantia, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Bioorganic & medicinal chemistry (15.01.2023)
Published in Bioorganic & medicinal chemistry (15.01.2023)
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Journal Article
Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885
Lemos, Clara, Nguyen, Duy, Wortmann, Lars, Bömer, Ulf, Holton, Simon, Lechner, Christian, Prechtl, Stefan, Sülzle, Detlev, Siegel, Franziska, Mumberg, Dominik, Bauser, Marcus, Hägebarth, Andrea
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 5873: BAY-3827, a selective inhibitor of AMPK for the evaluation of the role of AMPK in Myc-dependent tumors
Lemos, Clara, Schulze, Volker K., Bader, Benjamin, Christ, Clara D., Briem, Hans, Politz, Oliver, Prinz, Florian, Holton, Simon, Heinrich, Tobias, Lefranc, Julien, Lienau, Philip, Scholz, Arne, Nussbaum, Franz von, Nising, Carl Friedrich, Mumberg, Dominik, Bauser, Marcus, Hägebarth, Andrea
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 980: BAY-299, a novel chemical probe for in-depth analysis of the function of the bromodomain proteins BRPF2 and TAF1
Bouche, Lea, Christ, Clara D., Siegel, Stephan, Tallant, Cynthia, Fernández-Montalván, Amaury E., Huber, Kilian V., Pütter, Verra, Müller, Susanne, Fedorov, Oleg, Laak, Antonius ter, Sugawara, Tatsuo, Stöckigt, Detlef, Meier, Julia, Holton, Simon J., Hartung, Ingo V., Haendler, Bernard
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 287: BAY 1816032, a novel BUB1 kinase inhibitor with potent antitumor activity
Siemeister, Gerhard, Mengel, Anne, Bone, Wilhelm, Schröder, Jens, Zitzmann-Kolbe, Sabine, Briem, Hans, Fernández-Montalván, Amaury E., Holton, Simon, Mönning, Ursula, Ahsen, Oliver von, Johanssen, Sandra, Cleve, Arwed, Hitchcock, Marion, Meyer, Kirstin, Nussbaum, Franz von, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure
Poulsen, Christian, Holton, Simon, Geerlof, Arie, Wilmanns, Matthias, Song, Young-Hwa
Published in FEBS letters (19.02.2010)
Published in FEBS letters (19.02.2010)
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Journal Article
Abstract 2718: Synthesis and characterization of novel benzylpyrazole-based BUB1 kinase inhibitors with anti-tumor activity
Hitchcock, Marion, Siemeister, Gerhard, Briem, Hans, Fernandez-Montalvan, Amaury Ernest, Holton, Simon, Mengel, Anne, Mönning, Ursula, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik, Nussbaum, Franz von
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 4703: The BET inhibitor BAY 1238097 shows efficacy in BRAF wild-type and mutant melanoma models
Haendler, Bernard, Gelato, Kathy A., Schöckel, Laura, Sugawara, Tatsuo, Lejeune, Pascale, Ellinger-Ziegelbauer, Heidrun, Fernandez-Montalvan, Amaury E., Holton, Simon, Siegel, Stephan, Heroult, Melanie, Walter, Annette, Ince, Stuart, Ocker, Matthias
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 4539: ATAD2 mediates DNA replication in cancer
Koo, Seong Joo, Fernandez-Montalvan, Amaury Ernesto, Holton, Simon, von Ahsen, Oliver, Badock, Volker, Vittori, Sarah, Ott, Christopher J., Bradner, James E., Gorjanacz, Matyas
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 5084: Potent and isoform-selective ATAD2 bromodomain inhibitor with unprecedented chemical structure and mode of action
Fernández-Montalván, Amaury E., Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Holton, Simon J., Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James, Federov, Oleg, Huber, Kilian, Centrella, Paolo, Clark, Matthew A., Dumelin, Christoph E., Sigel, Eric A., Soutter, Holly S., Troast, Dawn M., Zhang, Ying, Cuozzo, John W., Keefe, Anthony D., Roche, Didier, Rodeschini, Vincent, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V., Gorjanacz, Matyas
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 5239: Probing the cancer epigenome: empowering target validation by open innovation
Hartung, Ingo V., Arrowsmith, Cheryl, Badock, Volker, Barak, Naomi, Berger, Markus, Brown, Peter J., Christ, Clara D., Eggert, Erik, Egner, Ursula, Fedorov, Oleg, Fernandez-Montalvan, Amaury E., Gorjanacz, Matyas, Haegebarth, Andrea, Haendler, Bernard, Hillig, Roman C., Holton, Simon H., Huber, Kilian V., Koo, Seong J., Laak, Antonius ter, Mueller, Susanne, Mueller-Fahrnow, Anke, Scholten, Cora, Siegel, Stephan, Stellfeld, Timo, Stoeckigt, Detlef, Stresemann, Carlo, Vedadi, Masoud, Weiske, Joerg, Weinmann, Hilmar
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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