Complement factor H in host defense and immune evasion
Parente, Raffaella, Clark, Simon J., Inforzato, Antonio, Day, Anthony J.
Published in Cellular and molecular life sciences : CMLS (01.05.2017)
Published in Cellular and molecular life sciences : CMLS (01.05.2017)
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Journal Article
Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
Cipriani, Valentina, Lorés-Motta, Laura, He, Fan, Fathalla, Dina, Tilakaratna, Viranga, McHarg, Selina, Bayatti, Nadhim, Acar, İlhan E., Hoyng, Carel B., Fauser, Sascha, Moore, Anthony T., Yates, John R. W., de Jong, Eiko K., Morgan, B. Paul, den Hollander, Anneke I., Bishop, Paul N., Clark, Simon J.
Published in Nature communications (07.02.2020)
Published in Nature communications (07.02.2020)
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Journal Article
Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration
Clark, Simon J, Schmidt, Christoph Q, White, Anne M, Hakobyan, Svetlana, Morgan, B Paul, Bishop, Paul N
Published in The Journal of immunology (1950) (15.11.2014)
Published in The Journal of immunology (1950) (15.11.2014)
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Journal Article
CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway
Armento, Angela, Schmidt, Tiziana L., Sonntag, Inga, Merle, David A., Jarboui, Mohamed Ali, Kilger, Ellen, Clark, Simon J., Ueffing, Marius
Published in International journal of molecular sciences (13.08.2021)
Published in International journal of molecular sciences (13.08.2021)
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Journal Article
Extra-viral DNA in adeno-associated viral vector preparations induces TLR9-dependent innate immune responses in human plasmacytoid dendritic cells
Bucher, Kirsten, Rodríguez-Bocanegra, Eduardo, Wissinger, Bernd, Strasser, Torsten, Clark, Simon J., Birkenfeld, Andreas L., Siegel-Axel, Dorothea, Fischer, M. Dominik
Published in Scientific reports (02.02.2023)
Published in Scientific reports (02.02.2023)
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Journal Article
Bruch's Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration
Clark, Simon J, McHarg, Selina, Tilakaratna, Viranga, Brace, Nicole, Bishop, Paul N
Published in Frontiers in immunology (19.12.2017)
Published in Frontiers in immunology (19.12.2017)
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Journal Article
Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina
Clark, Simon J., Perveen, Rahat, Hakobyan, Svetlana, Morgan, B. Paul, Sim, Robert B., Bishop, Paul N., Day, Anthony J.
Published in The Journal of biological chemistry (24.09.2010)
Published in The Journal of biological chemistry (24.09.2010)
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Journal Article
Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera
Keenan, Tiarnan D L, Clark, Simon J, Unwin, Richard D, Ridge, Liam A, Day, Anthony J, Bishop, Paul N
Published in Investigative ophthalmology & visual science (07.11.2012)
Published in Investigative ophthalmology & visual science (07.11.2012)
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Journal Article
FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress
Choudhury, Rawshan, Bayatti, Nadhim, Scharff, Richard, Szula, Ewa, Tilakaratna, Viranga, Udsen, Maja Søberg, McHarg, Selina, Askari, Janet A., Humphries, Martin J., Bishop, Paul N., Clark, Simon J.
Published in Scientific reports (08.07.2021)
Published in Scientific reports (08.07.2021)
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Journal Article
C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation
Swinkels, Maurice, Zhang, Justine H., Tilakaratna, Viranga, Black, Graeme, Perveen, Rahat, McHarg, Selina, Inforzato, Antonio, Day, Anthony J., Clark, Simon J.
Published in Scientific reports (26.01.2018)
Published in Scientific reports (26.01.2018)
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Journal Article
Shiga Toxin Activates Complement and Binds Factor H: Evidence for an Active Role of Complement in Hemolytic Uremic Syndrome
Orth, Dorothea, Khan, Abdul Basit, Naim, Asma, Grif, Katharina, Brockmeyer, Jens, Karch, Helge, Joannidis, Michael, Clark, Simon J, Day, Anthony J, Fidanzi, Sonja, Stoiber, Heribert, Dierich, Manfred P, Zimmerhackl, Lothar B, Wurzner, Reinhard
Published in The Journal of immunology (1950) (15.05.2009)
Published in The Journal of immunology (1950) (15.05.2009)
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Journal Article
Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds
Rafael, Diana, Guerrero, Marcelo, Marican, Adolfo, Arango, Diego, Sarmento, Bruno, Ferrer, Roser, Durán-Lara, Esteban F, Clark, Simon J, Schwartz, Jr, Simo
Published in Pharmaceutics (12.05.2023)
Published in Pharmaceutics (12.05.2023)
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Journal Article
Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid, and sclera
Clark, Simon J, Keenan, Tiarnan D L, Fielder, Helen L, Collinson, Lisa J, Holley, Rebecca J, Merry, Catherine L R, van Kuppevelt, Toin H, Day, Anthony J, Bishop, Paul N
Published in Investigative ophthalmology & visual science (17.08.2011)
Published in Investigative ophthalmology & visual science (17.08.2011)
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Journal Article
Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes
Porter, Louise F, Saptarshi, Neil, Fang, Yongxiang, Rathi, Sonika, den Hollander, Anneke I, de Jong, Eiko K, Clark, Simon J, Bishop, Paul N, Olsen, Timothy W, Liloglou, Triantafillos, Chavali, Venkata R M, Paraoan, Luminita
Published in Clinical epigenetics (14.01.2019)
Published in Clinical epigenetics (14.01.2019)
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Journal Article
Massive stars in the giant molecular cloud G23.3−0.3 and W41
Messineo, Maria, Menten, Karl M., Figer, Donald F., Davies, Ben, Simon Clark, J., Ivanov, Valentin D., Kudritzki, Rolf-Peter, Michael Rich, R., MacKenty, John W., Trombley, Christine
Published in Astronomy and astrophysics (Berlin) (01.09.2014)
Published in Astronomy and astrophysics (Berlin) (01.09.2014)
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Journal Article
Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration
Stravalaci, Matteo, Davi, Francesca, Parente, Raffaella, Gobbi, Marco, Bottazzi, Barbara, Mantovani, Alberto, Day, Anthony J, Clark, Simon J, Romano, Mario R, Inforzato, Antonio
Published in Frontiers in pharmacology (26.11.2020)
Published in Frontiers in pharmacology (26.11.2020)
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