GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
Huang, Sijie, Xu, Peiyu, Shen, Dan-Dan, Simon, Icaro A., Mao, Chunyou, Tan, Yangxia, Zhang, Huibing, Harpsøe, Kasper, Li, Huadong, Zhang, Yumu, You, Chongzhao, Yu, Xuekui, Jiang, Yi, Zhang, Yan, Gloriam, David E., Xu, H. Eric
Published in Molecular cell (21.07.2022)
Published in Molecular cell (21.07.2022)
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Structural insights into the lipid and ligand regulation of serotonin receptors
Xu, Peiyu, Huang, Sijie, Zhang, Huibing, Mao, Chunyou, Zhou, X Edward, Cheng, Xi, Simon, Icaro A, Shen, Dan-Dan, Yen, Hsin-Yung, Robinson, Carol V, Harpsøe, Kasper, Svensson, Bo, Guo, Jia, Jiang, Hualiang, Gloriam, David E, Melcher, Karsten, Jiang, Yi, Zhang, Yan, Xu, H Eric
Published in Nature (London) (15.04.2021)
Published in Nature (London) (15.04.2021)
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Journal Article
Electrochemical Behavior of Gold Nanoparticles Generated In Situ on 3-(1-Imidazolyl)propyl-silsesquioxane
Simon, Ícaro A., Vacaro, Bernardo B., Nunes, Michael R., Benvenutti, Edilson V., Dias, Silvio L. P., Gushikem, Yoshitaka, Arguello, Jacqueline
Published in Electroanalysis (New York, N.Y.) (01.11.2013)
Published in Electroanalysis (New York, N.Y.) (01.11.2013)
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Journal Article
Ligand selectivity hotspots in serotonin GPCRs
Simon, Icaro A, Bjørn-Yoshimoto, Walden E, Harpsøe, Kasper, Iliadis, Stylianos, Svensson, Bo, Jensen, Anders A, Gloriam, David E
Published in Trends in pharmacological sciences (Regular ed.) (01.12.2023)
Published in Trends in pharmacological sciences (Regular ed.) (01.12.2023)
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PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands
Simon, Icaro A., Homan, Evert J., Wijtmans, Maikel, Sundström, Michael, Leurs, Rob, De Esch, Iwan J. P., Zarzycka, Barbara A.
Published in Journal of chemical information and modeling (13.11.2023)
Published in Journal of chemical information and modeling (13.11.2023)
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Journal Article
Discovery of β‑Arrestin-Biased 25CN-NBOH-Derived 5‑HT2A Receptor Agonists
Poulie, Christian B. M., Pottie, Eline, Simon, Icaro A., Harpsøe, Kasper, D’Andrea, Laura, Komarov, Igor V., Gloriam, David E., Jensen, Anders A., Stove, Christophe P., Kristensen, Jesper L.
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3
Zarca, Aurelien M, Adlere, Ilze, Viciano, Cristina P, Arimont-Segura, Marta, Meyrath, Max, Simon, Icaro A, Bebelman, Jan Paul, Laan, Dennis, Custers, Hans G J, Janssen, Elwin, Versteegh, Kobus L, Buzink, Maurice C M L, Nesheva, Desislava N, Bosma, Reggie, de Esch, Iwan J P, Vischer, Henry F, Wijtmans, Maikel, Szpakowska, Martyna, Chevigné, Andy, Hoffmann, Carsten, de Graaf, Chris, Zarzycka, Barbara A, Windhorst, Albert D, Smit, Martine J, Leurs, Rob
Published in Molecular pharmacology (01.04.2024)
Published in Molecular pharmacology (01.04.2024)
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Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5‑HT2A Receptor Agonists
Pottie, Eline, Poulie, Christian B. M., Simon, Icaro A., Harpsøe, Kasper, D’Andrea, Laura, Komarov, Igor V., Gloriam, David E., Jensen, Anders A., Kristensen, Jesper L., Stove, Christophe P.
Published in ACS chemical neuroscience (02.08.2023)
Published in ACS chemical neuroscience (02.08.2023)
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Journal Article
Structure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT 2A Receptor Agonists
Pottie, Eline, Poulie, Christian B M, Simon, Icaro A, Harpsøe, Kasper, D'Andrea, Laura, Komarov, Igor V, Gloriam, David E, Jensen, Anders A, Kristensen, Jesper L, Stove, Christophe P
Published in ACS chemical neuroscience (02.08.2023)
Published in ACS chemical neuroscience (02.08.2023)
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Journal Article
CuO Nanofibers Immobilized on Paraffin-Impregnated Graphite Electrode and its Application in the Amperometric Detection of Glucose
Simon, Ícaro A., Medeiros, Natália G., Garcia, Ketlin C., Soares, Rosane M. D., Rosa, Aline T., Silva, Jacqueline A.
Published in Journal of the Brazilian Chemical Society (01.08.2015)
Published in Journal of the Brazilian Chemical Society (01.08.2015)
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Journal Article
Discovery of ss-Arrestin-Biased 25CN-NBOH-Derived 5-HT2A Receptor Agonists
Poulie, Christian B. M., Pottie, Eline, Simon, Icaro A., Harpsoe, Kasper, D'Andrea, Laura, Komarov, Igor V., Gloriam, David E., Jensen, Anders A., Stove, Christophe P., Kristensen, Jesper L.
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article
Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT 2A Receptor Agonists
Poulie, Christian B. M., Pottie, Eline, Simon, Icaro A., Harpsøe, Kasper, D’Andrea, Laura, Komarov, Igor V., Gloriam, David E., Jensen, Anders A., Stove, Christophe P., Kristensen, Jesper L.
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article