Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study
Abida, Wassim, Campbell, David, Patnaik, Akash, Shapiro, Jeremy D, Sautois, Brieuc, Vogelzang, Nicholas J, Voog, Eric G, Bryce, Alan H, McDermott, Ray, Ricci, Francesco, Rowe, Julie, Zhang, Jingsong, Piulats, Josep Maria, Fizazi, Karim, Merseburger, Axel S, Higano, Celestia S, Krieger, Laurence E, Ryan, Charles J, Feng, Felix Y, Simmons, Andrew D, Loehr, Andrea, Despain, Darrin, Dowson, Melanie, Green, Foad, Watkins, Simon P, Golsorkhi, Tony, Chowdhury, Simon
Published in Clinical cancer research (01.06.2020)
Published in Clinical cancer research (01.06.2020)
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Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration
Abida, Wassim, Patnaik, Akash, Campbell, David, Shapiro, Jeremy, Bryce, Alan H, McDermott, Ray, Sautois, Brieuc, Vogelzang, Nicholas J, Bambury, Richard M, Voog, Eric, Zhang, Jingsong, Piulats, Josep M, Ryan, Charles J, Merseburger, Axel S, Daugaard, Gedske, Heidenreich, Axel, Fizazi, Karim, Higano, Celestia S, Krieger, Laurence E, Sternberg, Cora N, Watkins, Simon P, Despain, Darrin, Simmons, Andrew D, Loehr, Andrea, Dowson, Melanie, Golsorkhi, Tony, Chowdhury, Simon
Published in Journal of clinical oncology (10.11.2020)
Published in Journal of clinical oncology (10.11.2020)
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Preclinical evaluation of FAP-2286 for fibroblast activation protein targeted radionuclide imaging and therapy
Zboralski, Dirk, Hoehne, Aileen, Bredenbeck, Anne, Schumann, Anne, Nguyen, Minh, Schneider, Eberhard, Ungewiss, Jan, Paschke, Matthias, Haase, Christian, von Hacht, Jan L., Kwan, Tanya, Lin, Kevin K., Lenore, Jan, Harding, Thomas C., Xiao, Jim, Simmons, Andrew D., Mohan, Ajay-Mohan, Beindorff, Nicola, Reineke, Ulrich, Smerling, Christiane, Osterkamp, Frank
Published in European journal of nuclear medicine and molecular imaging (01.09.2022)
Published in European journal of nuclear medicine and molecular imaging (01.09.2022)
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Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer
Shah, Khyati N., Bhatt, Roma, Rotow, Julia, Rohrberg, Julia, Olivas, Victor, Wang, Victoria E., Hemmati, Golzar, Martins, Maria M., Maynard, Ashley, Kuhn, Jonathan, Galeas, Jacqueline, Donnella, Hayley J., Kaushik, Swati, Ku, Angel, Dumont, Sophie, Krings, Gregor, Haringsma, Henry J., Robillard, Liliane, Simmons, Andrew D., Harding, Thomas C., McCormick, Frank, Goga, Andrei, Blakely, Collin M., Bivona, Trever G., Bandyopadhyay, Sourav
Published in Nature medicine (01.01.2019)
Published in Nature medicine (01.01.2019)
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Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
Blakely, Collin M, Watkins, Thomas B K, Wu, Wei, Gini, Beatrice, Chabon, Jacob J, McCoach, Caroline E, McGranahan, Nicholas, Wilson, Gareth A, Birkbak, Nicolai J, Olivas, Victor R, Rotow, Julia, Maynard, Ashley, Wang, Victoria, Gubens, Matthew A, Banks, Kimberly C, Lanman, Richard B, Caulin, Aleah F, St John, John, Cordero, Anibal R, Giannikopoulos, Petros, Simmons, Andrew D, Mack, Philip C, Gandara, David R, Husain, Hatim, Doebele, Robert C, Riess, Jonathan W, Diehn, Maximilian, Swanton, Charles, Bivona, Trever G
Published in Nature genetics (01.12.2017)
Published in Nature genetics (01.12.2017)
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Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients
Chabon, Jacob J., Simmons, Andrew D., Lovejoy, Alexander F., Esfahani, Mohammad S., Newman, Aaron M., Haringsma, Henry J., Kurtz, David M., Stehr, Henning, Scherer, Florian, Karlovich, Chris A., Harding, Thomas C., Durkin, Kathleen A., Otterson, Gregory A., Purcell, W. Thomas, Camidge, D. Ross, Goldman, Jonathan W., Sequist, Lecia V., Piotrowska, Zofia, Wakelee, Heather A., Neal, Joel W., Alizadeh, Ash A., Diehn, Maximilian
Published in Nature communications (10.06.2016)
Published in Nature communications (10.06.2016)
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A lateralized brain network for visuospatial attention
de Schotten, Michel Thiebaut, Dell'Acqua, Flavio, Forkel, Stephanie J, Simmons, Andrew, Vergani, Francesco, Murphy, Declan G M, Catani, Marco
Published in Nature neuroscience (01.10.2011)
Published in Nature neuroscience (01.10.2011)
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Can spherical deconvolution provide more information than fiber orientations? Hindrance modulated orientational anisotropy, a true-tract specific index to characterize white matter diffusion
Dell'Acqua, Flavio, Simmons, Andrew, Williams, Steven C.R., Catani, Marco
Published in Human brain mapping (01.10.2013)
Published in Human brain mapping (01.10.2013)
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Inactivation of Capicua drives cancer metastasis
Okimoto, Ross A, Breitenbuecher, Frank, Olivas, Victor R, Wu, Wei, Gini, Beatrice, Hofree, Matan, Asthana, Saurabh, Hrustanovic, Gorjan, Flanagan, Jennifer, Tulpule, Asmin, Blakely, Collin M, Haringsma, Henry J, Simmons, Andrew D, Gowen, Kyle, Suh, James, Miller, Vincent A, Ali, Siraj, Schuler, Martin, Bivona, Trever G
Published in Nature genetics (01.01.2017)
Published in Nature genetics (01.01.2017)
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Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Kondrashova, Olga, Nguyen, Minh, Shield-Artin, Kristy, Tinker, Anna V, Teng, Nelson N H, Harrell, Maria I, Kuiper, Michael J, Ho, Gwo-Yaw, Barker, Holly, Jasin, Maria, Prakash, Rohit, Kass, Elizabeth M, Sullivan, Meghan R, Brunette, Gregory J, Bernstein, Kara A, Coleman, Robert L, Floquet, Anne, Friedlander, Michael, Kichenadasse, Ganessan, O'Malley, David M, Oza, Amit, Sun, James, Robillard, Liliane, Maloney, Lara, Bowtell, David, Giordano, Heidi, Wakefield, Matthew J, Kaufmann, Scott H, Simmons, Andrew D, Harding, Thomas C, Raponi, Mitch, McNeish, Iain A, Swisher, Elizabeth M, Lin, Kevin K, Scott, Clare L
Published in Cancer discovery (01.09.2017)
Published in Cancer discovery (01.09.2017)
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Evaluation of in vitro absorption, distribution, metabolism, and excretion and assessment of drug-drug interaction of rucaparib, an orally potent poly(ADP-ribose) polymerase inhibitor
Liao, Mingxiang, Jaw-Tsai, Sarah, Beltman, Jeri, Simmons, Andrew D., Harding, Thomas C., Xiao, Jim J.
Published in Xenobiotica (01.09.2020)
Published in Xenobiotica (01.09.2020)
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Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC
Walter, Annette O, Sjin, Robert Tjin Tham, Haringsma, Henry J, Ohashi, Kadoaki, Sun, Jing, Lee, Kwangho, Dubrovskiy, Aleksandr, Labenski, Matthew, Zhu, Zhendong, Wang, Zhigang, Sheets, Michael, St Martin, Thia, Karp, Russell, van Kalken, Dan, Chaturvedi, Prasoon, Niu, Deqiang, Nacht, Mariana, Petter, Russell C, Westlin, William, Lin, Kevin, Jaw-Tsai, Sarah, Raponi, Mitch, Van Dyke, Terry, Etter, Jeff, Weaver, Zoe, Pao, William, Singh, Juswinder, Simmons, Andrew D, Harding, Thomas C, Allen, Andrew
Published in Cancer discovery (01.12.2013)
Published in Cancer discovery (01.12.2013)
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Frontoparietal Tracts Linked to Lateralized Hand Preference and Manual Specialization
Howells, Henrietta, Thiebaut de Schotten, Michel, Dell'Acqua, Flavio, Beyh, Ahmad, Zappalà, Giuseppe, Leslie, Anoushka, Simmons, Andrew, Murphy, Declan G, Catani, Marco
Published in Cerebral cortex (New York, N.Y. 1991) (01.07.2018)
Published in Cerebral cortex (New York, N.Y. 1991) (01.07.2018)
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Fibroblast activation protein targeted radiotherapy induces an immunogenic tumor microenvironment and enhances the efficacy of PD-1 immune checkpoint inhibition
Zboralski, Dirk, Osterkamp, Frank, Christensen, Esben, Bredenbeck, Anne, Schumann, Anne, Hoehne, Aileen, Schneider, Eberhard, Paschke, Matthias, Ungewiss, Jan, Haase, Christian, Robillard, Liliane, Simmons, Andrew D., Harding, Thomas C., Nguyen, Minh
Published in European journal of nuclear medicine and molecular imaging (01.07.2023)
Published in European journal of nuclear medicine and molecular imaging (01.07.2023)
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Clinical Pharmacokinetics and Pharmacodynamics of Rucaparib
Liao, Mingxiang, Beltman, Jeri, Giordano, Heidi, Harding, Thomas C., Maloney, Lara, Simmons, Andrew D., Xiao, Jim J.
Published in Clinical pharmacokinetics (01.11.2022)
Published in Clinical pharmacokinetics (01.11.2022)
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Emergence of BRCA Reversion Mutations in Patients with Metastatic Castration-resistant Prostate Cancer After Treatment with Rucaparib
Loehr, Andrea, Hussain, Arif, Patnaik, Akash, Bryce, Alan H., Castellano, Daniel, Font, Albert, Shapiro, Jeremy, Zhang, Jingsong, Sautois, Brieuc, Vogelzang, Nicholas J., Chatta, Gurkamal, Courtney, Kevin, Harzstark, Andrea, Ricci, Francesco, Despain, Darrin, Watkins, Simon, King, Charmin, Nguyen, Minh, Simmons, Andrew D., Chowdhury, Simon, Abida, Wassim
Published in European urology (01.03.2023)
Published in European urology (01.03.2023)
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A modified damped Richardson–Lucy algorithm to reduce isotropic background effects in spherical deconvolution
Dell'Acqua, Flavio, Scifo, Paola, Rizzo, Giovanna, Catani, Marco, Simmons, Andrew, Scotti, Giuseppe, Fazio, Ferruccio
Published in NeuroImage (Orlando, Fla.) (15.01.2010)
Published in NeuroImage (Orlando, Fla.) (15.01.2010)
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Distinct subtypes of Alzheimer’s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications
Ferreira, Daniel, Verhagen, Chloë, Hernández-Cabrera, Juan Andrés, Cavallin, Lena, Guo, Chun-Jie, Ekman, Urban, Muehlboeck, J-Sebastian, Simmons, Andrew, Barroso, José, Wahlund, Lars-Olof, Westman, Eric
Published in Scientific reports (18.04.2017)
Published in Scientific reports (18.04.2017)
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Rucaparib for the Treatment of Metastatic Castration-resistant Prostate Cancer Associated with a DNA Damage Repair Gene Alteration: Final Results from the Phase 2 TRITON2 Study
Abida, Wassim, Campbell, David, Patnaik, Akash, Bryce, Alan H., Shapiro, Jeremy, Bambury, Richard M., Zhang, Jingsong, Burke, John M., Castellano, Daniel, Font, Albert, Ganju, Vinod, Hardy-Bessard, Anne-Claire, McDermott, Ray, Sautois, Brieuc, Spaeth, Dominique, Voog, Eric, Piulats, Josep M., Pintus, Elias, Ryan, Charles J., Merseburger, Axel S., Daugaard, Gedske, Heidenreich, Axel, Fizazi, Karim, Loehr, Andrea, Despain, Darrin, Simmons, Andrew D., Dowson, Melanie, Go, Jowell, Watkins, Simon P., Chowdhury, Simon
Published in European urology (01.09.2023)
Published in European urology (01.09.2023)
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