The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER
Hall, Belinda S, Hill, Kirsti, McKenna, Michael, Ogbechi, Joy, High, Stephen, Willis, Anne E, Simmonds, Rachel E
Published in PLoS pathogens (01.04.2014)
Published in PLoS pathogens (01.04.2014)
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Journal Article
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state
Bhadra, Pratiti, Dos Santos, Scott, Gamayun, Igor, Pick, Tillman, Neumann, Clarissa, Ogbechi, Joy, Hall, Belinda S, Zimmermann, Richard, Helms, Volkhard, Simmonds, Rachel E, Cavalié, Adolfo
Published in Biochemical journal (26.11.2021)
Published in Biochemical journal (26.11.2021)
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Journal Article
Structure of the Inhibited State of the Sec Translocon
Gérard, Samuel F., Hall, Belinda S., Zaki, Afroditi M., Corfield, Katherine A., Mayerhofer, Peter U., Costa, Catia, Whelligan, Daniel K., Biggin, Philip C., Simmonds, Rachel E., Higgins, Matthew K.
Published in Molecular cell (06.08.2020)
Published in Molecular cell (06.08.2020)
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Journal Article
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
Ogbechi, Joy, Hall, Belinda S., Sbarrato, Thomas, Taunton, Jack, Willis, Anne E., Wek, Ronald C., Simmonds, Rachel E.
Published in Cell death & disease (14.03.2018)
Published in Cell death & disease (14.03.2018)
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Journal Article
Editorial: Host-pathogen interactions in nontuberculous mycobacterial infections
Lorè, Nicola Ivan, Yamasaki, Sho, Simmonds, Rachel E, Jo, Eun-Kyeong
Published in Frontiers in immunology (26.05.2023)
Published in Frontiers in immunology (26.05.2023)
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Journal Article
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions
Hsieh, Louise Tzung-Harn, Dos Santos, Scott J, Hall, Belinda S, Ogbechi, Joy, Loglo, Aloysius D, Salguero, Francisco Javier, Ruf, Marie-Thérèse, Pluschke, Gerd, Simmonds, Rachel E
Published in PLoS pathogens (01.01.2022)
Published in PLoS pathogens (01.01.2022)
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Journal Article
Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F
O'Keefe, Sarah, Bhadra, Pratiti, Duah, Kwabena B, Zong, Guanghui, Tenay, Levise, Andrews, Lauren, Schneider, Hayden, Anderson, Ashley, Hu, Zhijian, Aljewari, Hazim S, Hall, Belinda S, Simmonds, Rachel E, Helms, Volkhard, High, Stephen, Shi, Wei Q
Published in Molecules (Basel, Switzerland) (10.07.2022)
Published in Molecules (Basel, Switzerland) (10.07.2022)
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Journal Article
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions
Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S, Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T, Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E
Published in PLoS pathogens (01.07.2015)
Published in PLoS pathogens (01.07.2015)
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Journal Article
Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures
Sacre, Sandra M, Lo, Alexandra, Gregory, Bernard, Simmonds, Rachel E, Williams, Lynn, Feldmann, Marc, Brennan, Fionula M, Foxwell, Brian M
Published in The Journal of immunology (1950) (01.12.2008)
Published in The Journal of immunology (1950) (01.12.2008)
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Journal Article
Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis
McKenna, Michael, Simmonds, Rachel E, High, Stephen
Published in Journal of cell science (01.04.2017)
Published in Journal of cell science (01.04.2017)
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Journal Article
Multisensory medical illustrations of Buruli ulcer for improved disease detection, help seeking behaviour and adherence to treatment
Butler, Joanna, Ogden, Jane, Phillips, Richard, Hay, Roderick, Simmonds, Rachel E, Erolin, Caroline
Published in Journal of visual communication in medicine (2024)
Published in Journal of visual communication in medicine (2024)
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Journal Article
Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity
Hall, Belinda S, Dos Santos, Scott J, Hsieh, Louise Tzung-Harn, Manifava, Maria, Ruf, Marie-Thérèse, Pluschke, Gerd, Ktistakis, Nicholas, Simmonds, Rachel E
Published in Autophagy (03.04.2022)
Published in Autophagy (03.04.2022)
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Journal Article
Haemostatic genetic risk factors in arterial thrombosis
Simmonds, R E, Hermida, J, Rezende, S M, Lane, D A
Published in Thrombosis and haemostasis (01.07.2001)
Published in Thrombosis and haemostasis (01.07.2001)
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