Silver Nanoparticles Induce Degradation of the Endoplasmic Reticulum Stress Sensor Activating Transcription Factor-6 Leading to Activation of the NLRP-3 Inflammasome
Simard, Jean-Christophe, Vallieres, Francis, de Liz, Rafael, Lavastre, Valerie, Girard, Denis
Published in The Journal of biological chemistry (27.02.2015)
Published in The Journal of biological chemistry (27.02.2015)
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S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.)
Simard, Jean-Christophe, Cesaro, Annabelle, Chapeton-Montes, Julie, Tardif, Mélanie, Antoine, Francis, Girard, Denis, Tessier, Philippe A
Published in PloS one (2013)
Published in PloS one (2013)
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Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism
Simard, Jean‐Christophe, Girard, Denis, Tessier, Philippe A.
Published in Journal of leukocyte biology (01.05.2010)
Published in Journal of leukocyte biology (01.05.2010)
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PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway
Grouix, Brigitte, Sarra-Bournet, Francois, Leduc, Martin, Simard, Jean-Christophe, Hince, Kathy, Geerts, Lilianne, Blais, Alexandra, Gervais, Liette, Laverdure, Alexandre, Felton, Alexandra, Richard, Jonathan, Ouboudinar, Jugurtha, Gagnon, William, Leblond, François A., Laurin, Pierre, Gagnon, Lyne
Published in The Journal of pharmacology and experimental therapeutics (01.10.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2018)
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PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice
Thibodeau, Jean-François, Simard, Jean-Christophe, Holterman, Chet E, Blais, Amélie, Cloutier, Marie-Pier, Medeiros, Thalia, Leduc, Martin, Grouix, Brigitte, Leblond, François A, Burger, Dylan, Hébert, Richard L, Kennedy, Christopher R J, Gagnon, Lyne
Published in Clinical science (1979) (31.07.2019)
Published in Clinical science (1979) (31.07.2019)
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Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9
Pelletier, Martin, Simard, Jean-Christophe, Girard, Denis, Tessier, Philippe A.
Published in Blood advances (22.05.2018)
Published in Blood advances (22.05.2018)
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Silver nanoparticles rapidly induce atypical human neutrophil cell death by a process involving inflammatory caspases and reactive oxygen species and induce neutrophil extracellular traps release upon cell adhesion
Liz, Rafael, Simard, Jean-Christophe, Leonardi, Laurien Bruna Araújo, Girard, Denis
Published in International immunopharmacology (01.09.2015)
Published in International immunopharmacology (01.09.2015)
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Interaction between silver nanoparticles of 20nm (AgNP20) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates
Poirier, Michelle, Simard, Jean-Christophe, Antoine, Francis, Girard, Denis
Published in Journal of applied toxicology (01.04.2014)
Published in Journal of applied toxicology (01.04.2014)
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A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84
Gagnon, Lyne, Leduc, Martin, Thibodeau, Jean-Francois, Zhang, Ming-Zhi, Grouix, Brigitte, Sarra-Bournet, Francois, Gagnon, William, Hince, Kathy, Tremblay, Mikaël, Geerts, Lilianne, Kennedy, Christopher R J, Hébert, Richard L, Gutsol, Alex, Holterman, Chet E, Kamto, Eldjonai, Gervais, Liette, Ouboudinar, Jugurtha, Richard, Jonathan, Felton, Alexandra, Laverdure, Alexandre, Simard, Jean-Christophe, Létourneau, Sylvie, Cloutier, Marie-Pier, Leblond, Francois A, Abbott, Shaun D, Penney, Christopher, Duceppe, Jean-Simon, Zacharie, Boulos, Dupuis, Jocelyn, Calderone, Angelino, Nguyen, Quang T, Harris, Raymond C, Laurin, Pierre
Published in The American journal of pathology (01.05.2018)
Published in The American journal of pathology (01.05.2018)
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Silver nanoparticles of 70 nm and 20 nm affect differently the biology of human neutrophils
Poirier, Michelle, Simard, Jean-Christophe, Girard, Denis
Published in Journal of immunotoxicology (03.05.2016)
Published in Journal of immunotoxicology (03.05.2016)
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Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease
Simard, Jean-Christophe, Thibodeau, Jean-François, Leduc, Martin, Tremblay, Mikael, Laverdure, Alexandre, Sarra-Bournet, François, Gagnon, William, Ouboudinar, Jugurtha, Gervais, Liette, Felton, Alexandra, Letourneau, Sylvie, Geerts, Lilianne, Cloutier, Marie-Pier, Hince, Kathy, Corpuz, Ramon, Blais, Alexandra, Quintela, Vanessa Marques, Duceppe, Jean-Simon, Abbott, Shaun D, Blais, Amélie, Zacharie, Boulos, Laurin, Pierre, Laplante, Steven R, Kennedy, Christopher R J, Hébert, Richard L, Leblond, François A, Grouix, Brigitte, Gagnon, Lyne
Published in Scientific reports (29.07.2020)
Published in Scientific reports (29.07.2020)
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Prolonged cultures of unstimulated human neutrophils lead to the apparition and persistence of rest-in-plate structures (RIPs) recognized by professional phagocytes in vitro and in vivo
Vallières, Francis, Simard, Jean-Christophe, Stafford-Richard, Théo, Girard, Denis
Published in The international journal of biochemistry & cell biology (01.12.2015)
Published in The international journal of biochemistry & cell biology (01.12.2015)
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Activation of human AML14.3D10 eosinophils by nanoparticles: Modulatory activity on apoptosis and cytokine production
Vallières, Francis, Simard, Jean-Christophe, Noël, Claudie, Murphy-Marion, Maxime, Lavastre, Valerie, Girard, Denis
Published in Journal of immunotoxicology (01.11.2016)
Published in Journal of immunotoxicology (01.11.2016)
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Journal Article
Interaction between silver nanoparticles of 20 nm (AgNP20) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates
Poirier, Michelle, Simard, Jean-Christophe, Antoine, Francis, Girard, Denis
Published in Journal of applied toxicology (01.04.2014)
Published in Journal of applied toxicology (01.04.2014)
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Journal Article
Interaction between silver nanoparticles of 20 nm (AgNP 20 ) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP 20 aggregates
Poirier, Michelle, Simard, Jean‐Christophe, Antoine, Francis, Girard, Denis
Published in Journal of applied toxicology (01.04.2014)
Published in Journal of applied toxicology (01.04.2014)
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Journal Article