Single Cell Characterisation of Transcriptional Programmes of Responsive and Resistant Leukaemic Progenitors in IDH2-Mutant Acute Myeloid Leukaemia in the AG221-AML-005 Study
Chatzikyriakou, Prodromos, Silveira, Douglas RA, Casares Aláez, Maria del Pilar, Usukhbayar, Batchimeg, Metzner, Marlen, Vyas, Paresh, Gandhi, Anita K., Risueño, Alberto, Hasan, Maroof, Quek, Lynn
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Single-Cell Transcriptome Analysis Reveals Pathways That Drive Dyserythropoiesis in Myelodysplastic Syndromes, Which Are Targeted By Luspatercept
Chowdhury, Onima, Silveira, Douglas RA, Reed, Sophie, O'Sullivan, Jennifer, Clark, Sally-Ann, Ashley, Neil, Psaila, Bethan, Thongjuea, Supat, Mead, Adam J, Quek, Lynn
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Metformin-Induced Ferroptosis Is a Therapeutic Vulnerability in IDH2 -Mutant AML Linked to Metabolic Rewiring Towards Fatty Acid Oxidation
Sternadt, Dominique, Pereira-Martins, Diego, Silveira, Douglas RA, Weinhaeuser, Isabel, Yang, Ming, Chatzikyriakou, Prodromos, Casares Alaez, Pilar, Ammatuna, Emanuele, Oudejans, Lieve, Huls, Gerwin A., Frezza, Christian, Quek, Lynn, Schuringa, Jan Jacob
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment
Weinhaeuser, Isabel, Pereira-Martins, Diego, Yamamoto de Almeida, Luciana, Hilberink, Jacobien R, Silveira, Douglas RA, Quek, Lynn, Ortiz, César Alexander, Lucena-Araujo, Antonio R., Visser, Nienke, Ammatuna, Emanuele, Huls, Gerwin A., Rego, Eduardo M, Schuringa, Jan Jacob
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Impaired Metabolic Plasticity Under Stress Constitutes a Therapeutic Vulnerability in IDH1/2-Mutant Acute Myeloid Leukemia
Sternadt, Dominique, Pereira-Martins, Diego, Silveira, Douglas RA, Chatzikyriakou, Prodromos, Casares Alaez, Maria del Pilar, Weinhaeuser, Isabel, Hogeling, Shanna M, Ammatuna, Emanuele, Huls, Gerwin A., Quek, Lynn, Schuringa, Jan Jacob
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53 mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia
Pereira-Martins, Diego, Ortiz Rojas, César Alexander, Weinhaeuser, Isabel, Wierenga, Bart-Jan, Van Den Boom, Vincent, Mojallali, Fatemeh, Sternadt, Dominique, Bianco, Thiago Mantello, van der Meer, Nisha, Silveira, Douglas RA, Quek, Lynn, Ammatuna, Emanuele, Lucena-Araujo, Antonio R, Huls, Gerwin A., Rego, Eduardo Magalhães, Schuringa, Jan Jacob
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Metabolism-Related Features Identify the Combination Metformin Plus NAMPT Inhibitors As a Selective Treatment Strategy in Acute Myeloid Leukemia
Weinhaeuser, Isabel, Pereira-Martins, Diego, Sternadt, Dominique, Griessinger, Emmanuel F, Silveira, Douglas RA, Coelho-Silva, Juan L, Alves-Silva, Antonio Bruno, Erdem, Ayşegül, Duarte, Bruno Koza Lino, Quek, Lynn, Traina, Fabiola, Saad, Sara Teresinha Olalla, Hilberink, Jacobien R, Ammatuna, Emanuele, Rego, Eduardo Magalhães, Huls, Geert A., Lucena-Araujo, Antonio R, Schuringa, Jan Jacob
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia In Vivo
Weinhäuser, Isabel, Pereira-Martins, Diego A, Hilberink, Jacobien R, Almeida, Luciana Yamamoto, Silveira, Douglas RA, Quek, Lynn, Hogeling, Shanna M, Mota, Jose Mauricio, Ammatuna, Emanuele, Lucena-Araujo, Antonio R., Huls, Gerwin A., Schuringa, Jan Jacob, Rego, Eduardo M
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia
Silveira, Douglas RA RA, Chatzikyriakou, Prodromos, Casares Alaez, Maria del Pilar, Mackie, Sarah, Hulks, Roan, Yavorska, Olena, Siejka-Zielinska, Paulina, Metzner, Marlen, Smith, Alastair, Usukhbayar, Batchimeg, Penard-Lacronique, Virginie, Song, Chunxiao, Gandhi, Anita K., Hasan, Maroof, Vyas, Paresh, Milne, Thomas A., Kriaucionis, Skirmantas, Quek, Lynn
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
High MN1 Expression Is Associated with an Lspc-Enriched Phenotype and Glycolysis Representing a New Vulnerability in Acute Myeloid Leukemia
Pereira-Martins, Diego, van Dijk, Noortje, Weinhaeuser, Isabel, Silveira, Douglas RA, Coelho Da Silva, Juan, Bianco, Thiago M, Ortiz, César Alexander, Traina, Fabiola, Figueiredo-Pontes, Lorena L, Ammatuna, Emanuele, Quek, Lynn, Huls, Gerwin A., Lucena-Araujo, Antonio R., Rego, Eduardo M, Schuringa, Jan Jacob
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Repressed Chromatin Drives Leukaemogenesis in Mutant IDH2 Acute Myeloid Leukaemia Via Inhibition of Granulocyte Differentiation and Cell Cycle Progression
Silveira, Douglas RA, Chatzikyriakou, Prodromos, Yavorska, Olena, Mackie, Sarah, Hulks, Roan, Siejka-Zielinska, Paulina, Corby, Anna, Smith, Alastair, Brown, Benjamin, Metzner, Marlen, Milne, Thomas A., Penard-Lacronique, Virginie, Song, Chunxiao, Hasan, Maroof, Thakurta, Anjan, Vyas, Paresh, Kriaucionis, Skirmantas, Quek, Lynn
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Clinical Significance of Mitochondrial DNA Content in Acute Promyelocytic Leukemia
Lucena-Araujo, Antonio R., Pereira-Martins, Diego A, Coelho-Silva, Juan L, Weinhäuser, Isabel, Franca-Neto, Pedro Luis, Silveira, Douglas RA, Lima, Marinus M, Schuringa, Jan Jacob, Koury, Luisa C, Melo, Raul Antônio Morais, Bittencourt, Rosane, Pagnano, Katia B, Nunes, Elenaide C., Fagundes, Evandro Maranhão, Kerbauy, Fabio R., Figueredo-Pontes, Lorena, Rego, Eduardo M
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article