The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant
Rajagopal, Badri S, Edzuma, Ann N, Hough, Michael A, Blundell, Katie L I M, Kagan, Valerian E, Kapralov, Alexandr A, Fraser, Lewis A, Butt, Julea N, Silkstone, Gary G, Wilson, Michael T, Svistunenko, Dimitri A, Worrall, Jonathan A R
Published in Biochemical journal (15.12.2013)
Published in Biochemical journal (15.12.2013)
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Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality
Cooper, Chris E, Silkstone, Gary G. A, Simons, Michelle, Gretton, Svetlana, Rajagopal, Badri S, Allen-Baume, Victoria, Syrett, Natalie, Shaik, Thoufieq, Popa, Gina, Sheng, XiaoBo, Bird, Matthew, Choi, Ji-Won, Piano, Riccardo, Ronda, Luca, Bettati, Stefano, Paredi, Gianluca, Mozzarelli, Andrea, Reeder, Brandon J
Published in Biomaterials science (21.07.2020)
Published in Biomaterials science (21.07.2020)
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Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells
Godoy, Luiz C, Muñoz-Pinedo, Cristina, Castro, Laura, Cardaci, Simone, Schonhoff, Christopher M, King, Michael, Tórtora, Verónica, Marín, Mónica, Miao, Qian, Jiang, Jian Fei, Kapralov, Alexandr, Jemmerson, Ronald, Silkstone, Gary G, Patel, Jinal N, Evans, James E, Wilson, Michael T, Green, Douglas R, Kagan, Valerian E, Radi, Rafael, Mannick, Joan B
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
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EPR and Optical Spectroscopic Studies of Met80X Mutants of Yeast Ferricytochrome c. Models for Intermediates in the Alkaline Transition
Silkstone, Gary G, Cooper, Christopher E, Svistunenko, Dimitri, Wilson, Michael T
Published in Journal of the American Chemical Society (12.01.2005)
Published in Journal of the American Chemical Society (12.01.2005)
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Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute
Cooper, Chris E., Silkstone, Gary G.A., Simons, Michelle, Rajagopal, Badri, Syrett, Natalie, Shaik, Thoufieq, Gretton, Svetlana, Welbourn, Elizabeth, Bülow, Leif, Eriksson, Nélida Leiva, Ronda, Luca, Mozzarelli, Andrea, Eke, Andras, Mathe, Domokos, Reeder, Brandon J.
Published in Free radical biology & medicine (01.04.2019)
Published in Free radical biology & medicine (01.04.2019)
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Taming hemoglobin chemistry-a new hemoglobin-based oxygen carrier engineered with both decreased rates of nitric oxide scavenging and lipid oxidation
Cooper, Chris E, Simons, Michelle, Dyson, Alex, Leiva Eriksson, Nélida, Silkstone, Gary G A, Syrett, Natalie, Allen-Baume, Victoria, Bülow, Leif, Ronda, Luca, Mozzarelli, Andrea, Singer, Mervyn, Reeder, Brandon J
Published in Experimental & molecular medicine (01.10.2024)
Published in Experimental & molecular medicine (01.10.2024)
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Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design
Silkstone, Gary G A, Silkstone, Rebecca S, Wilson, Michael T, Simons, Michelle, Bülow, Leif, Kallberg, Kristian, Ratanasopa, Khuanpiroon, Ronda, Luca, Mozzarelli, Andrea, Reeder, Brandon J, Cooper, Chris E
Published in Biochemical journal (01.10.2016)
Published in Biochemical journal (01.10.2016)
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Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers
Simons, Michelle, Gretton, Svetlana, Silkstone, Gary G A, Rajagopal, Badri S, Allen-Baume, Victoria, Syrett, Natalie, Shaik, Thoufieq, Leiva-Eriksson, Nelida, Ronda, Luca, Mozzarelli, Andrea, Strader, Michael B, Alayash, Abdu I, Reeder, Brandon J, Cooper, Chris E
Published in Bioscience reports (31.08.2018)
Published in Bioscience reports (31.08.2018)
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Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit
Cooper, Chris E, Bird, Matthew, Sheng, XiaoBo, Choi, Ji-Won, Silkstone, Gary G A, Simons, Michelle, Syrett, Natalie, Piano, Riccardo, Ronda, Luca, Bettati, Stefano, Paredi, Gianluca, Mozzarelli, Andrea, Reeder, Brandon J
Published in Frontiers in chemistry (26.07.2021)
Published in Frontiers in chemistry (26.07.2021)
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