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Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances
Timmers, Paul RHJ, Mounier, Ninon, Lall, Kristi, Fischer, Krista, Ning, Zheng, Feng, Xiao, Bretherick, Andrew D, Clark, David W, Agbessi, M, Ahsan, H, Alves, I, Andiappan, A, Awadalla, P, Battle, A, Bonder, MJ, Boomsma, D, Christiansen, M, Claringbould, A, Deelen, P, van Dongen, J, Esko, T, Favé, M, Franke, L, Frayling, T, Gharib, SA, Gibson, G, Hemani, G, Jansen, R, Kalnapenkis, A, Kasela, S, Kettunen, J, Kim, Y, Kirsten, H, Kovacs, P, Krohn, K, Kronberg-Guzman, J, Kukushkina, V, Kutalik, Z, Kähönen, M, Lee, B, Lehtimäki, T, Loeffler, M, Marigorta, U, Metspalu, A, van Meurs, J, Milani, L, Müller-Nurasyid, M, Nauck, M, Nivard, M, Penninx, B, Perola, M, Pervjakova, N, Pierce, B, Powell, J, Prokisch, H, Psaty, BM, Raitakari, O, Ring, S, Ripatti, S, Rotzschke, O, Ruëger, S, Saha, A, Scholz, M, Schramm, K, Seppälä, I, Stumvoll, M, Sullivan, P, Teumer, A, Thiery, J, Tong, L, Tönjes, A, Verlouw, J, Visscher, PM, Võsa, U, Völker, U, Yaghootkar, H, Yang, J, Zeng, B, Zhang, F, Shen, Xia, Esko, Tõnu, Kutalik, Zoltán, Wilson, James F, Joshi, Peter K
Published in eLife (15.01.2019)
Published in eLife (15.01.2019)
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Context-dependent transcriptional regulations between signal transduction pathways
Hwang, Sohyun, Kim, Sangwoo, Shin, Heesung, Lee, Doheon
Published in BMC bioinformatics (13.01.2011)
Published in BMC bioinformatics (13.01.2011)
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Transcriptomic Evidence Reveals the Dysfunctional Mechanism of Synaptic Plasticity Control in ASD
Kong, Chao, Bing, Zhitong, Yang, Lei, Huang, Zigang, Wang, Wenxu, Grebogi, Celso
Published in Genes (01.01.2025)
Published in Genes (01.01.2025)
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Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma
Wilson, Wyndham H, Young, Ryan M, Schmitz, Roland, Yang, Yandan, Pittaluga, Stefania, Wright, George, Lih, Chih-Jian, Williams, P Mickey, Shaffer, Arthur L, Gerecitano, John, de Vos, Sven, Goy, Andre, Kenkre, Vaishalee P, Barr, Paul M, Blum, Kristie A, Shustov, Andrei, Advani, Ranjana, Fowler, Nathan H, Vose, Julie M, Elstrom, Rebecca L, Habermann, Thomas M, Barrientos, Jacqueline C, McGreivy, Jesse, Fardis, Maria, Chang, Betty Y, Clow, Fong, Munneke, Brian, Moussa, Davina, Beaupre, Darrin M, Staudt, Louis M
Published in Nature medicine (01.08.2015)
Published in Nature medicine (01.08.2015)
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Longevity‐related molecular pathways are subject to midlife “switch” in humans
Timmons, James A., Volmar, Claude‐Henry, Crossland, Hannah, Phillips, Bethan E., Sood, Sanjana, Janczura, Karolina J., Törmäkangas, Timo, Kujala, Urho M., Kraus, William E., Atherton, Philip J., Wahlestedt, Claes
Published in Aging cell (01.08.2019)
Published in Aging cell (01.08.2019)
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Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases
Patterson, H., Nibbs, R., McInnes, I., Siebert, S.
Published in Clinical and experimental immunology (01.04.2014)
Published in Clinical and experimental immunology (01.04.2014)
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Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression
Dudek, Katarzyna A., Dion-Albert, Laurence, Lebel, Manon, LeClairc, Katherine, Labrecque, Simon, Tuck, Ellen, Perez, Carmen Ferrer, Golden, Sam A., Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J., Menard, Caroline
Published in Proceedings of the National Academy of Sciences - PNAS (11.02.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (11.02.2020)
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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2013)
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Physical Activity and Redox Balance in the Elderly: Signal Transduction Mechanisms
Galli, Daniela, Carubbi, Cecilia, Masselli, Elena, Vaccarezza, Mauro, Presta, Valentina, Pozzi, Giulia, Ambrosini, Luca, Gobbi, Giuliana, Vitale, Marco, Mirandola, Prisco
Published in Applied sciences (01.03.2021)
Published in Applied sciences (01.03.2021)
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Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive impairment and late‐stage AD
Tramutola, Antonella, Triplett, Judy C., Di Domenico, Fabio, Niedowicz, Dana M., Murphy, Michael P., Coccia, Raffaella, Perluigi, Marzia, Butterfield, D. Allan
Published in Journal of neurochemistry (01.06.2015)
Published in Journal of neurochemistry (01.06.2015)
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Erythrocyte Signal Transduction Pathways, their Oxygenation Dependence and Functional Significance
Barvitenko, Nadezhda, Adragna, Norma, Weber, Roy
Published in Cellular physiology and biochemistry (01.01.2005)
Published in Cellular physiology and biochemistry (01.01.2005)
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Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise
Yu, Mei, Stepto, Nigel K., Chibalin, Alexander V., Fryer, Lee G. D., Carling, Dave, Krook, Anna, Hawley, John A., Zierath, Juleen R.
Published in The Journal of physiology (15.01.2003)
Published in The Journal of physiology (15.01.2003)
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Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants
Martín-Hernández, David, Caso, Javier R., Javier Meana, J., Callado, Luis F., Madrigal, José L. M., García-Bueno, Borja, Leza, Juan C.
Published in Journal of neuroinflammation (04.09.2018)
Published in Journal of neuroinflammation (04.09.2018)
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Melanopsin-Based Brightness Discrimination in Mice and Humans
Brown, Timothy M., Tsujimura, Sei-ichi, Allen, Annette E., Wynne, Jonathan, Bedford, Robert, Vickery, Graham, Vugler, Anthony, Lucas, Robert J.
Published in Current biology (19.06.2012)
Published in Current biology (19.06.2012)
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Genome-wide association studies of brain imaging phenotypes in UK Biobank
Elliott, Lloyd T., Sharp, Kevin, Alfaro-Almagro, Fidel, Shi, Sinan, Miller, Karla L., Douaud, Gwenaëlle, Marchini, Jonathan, Smith, Stephen M.
Published in Nature (London) (01.10.2018)
Published in Nature (London) (01.10.2018)
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Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
Nakamura, Toshitaka, Naguro, Isao, Ichijo, Hidenori
Published in Biochimica et biophysica acta. General subjects (01.09.2019)
Published in Biochimica et biophysica acta. General subjects (01.09.2019)
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