Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
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Published in Scientific reports (10.06.2015)
Published in Scientific reports (10.06.2015)
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Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry
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Published in Journal of medicinal chemistry (23.07.2020)
Published in Journal of medicinal chemistry (23.07.2020)
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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding
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Published in Journal of medicinal chemistry (27.08.2020)
Published in Journal of medicinal chemistry (27.08.2020)
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Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library
Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.
Published in Chembiochem : a European journal of chemical biology (04.05.2017)
Published in Chembiochem : a European journal of chemical biology (04.05.2017)
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Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa
Ryan, M. Dominic, Parkes, Alastair L, Corbett, David, Dickie, Anthony P, Southey, Michelle, Andersen, Ole A, Stein, Daniel B, Barbeau, Olivier R, Sanzone, Angelo, Thommes, Pia, Barker, John, Cain, Ricky, Compper, Christel, Dejob, Magali, Dorali, Alain, Etheridge, Donnya, Evans, Sian, Faulkner, Adele, Gadouleau, Elise, Gorman, Timothy, Haase, Denes, Holbrow-Wilshaw, Maisie, Krulle, Thomas, Li, Xianfu, Lumley, Christopher, Mertins, Barbara, Napier, Spencer, Odedra, Rajesh, Papadopoulos, Kostas, Roumpelakis, Vasileios, Spear, Kate, Trimby, Emily, Williams, Jennifer, Zahn, Michael, Keefe, Anthony D, Zhang, Ying, Soutter, Holly T, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Deng, Boer, Hunt, Avery, Sigel, Eric A, Troast, Dawn M, DeJonge, Boudewijn L. M
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology
Soutter, Holly H., Centrella, Paolo, Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph E., Guie, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Kennedy, Kaitlyn M., Sigel, Eric A., Troast, Dawn M., Zhang, Ying, Ferguson, Andrew D., Davies, Gareth, Stead, Eleanor R., Breed, Jason, Madhavapeddi, Prashanti, Read, Jon A.
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2016)
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Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
Fernández-Montalván, Amaury E, Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Puetter, Vera, Holton, Simon J, Stöckigt, Detlef, ter Laak, Antonius, Centrella, Paolo A, Clark, Matthew A, Dumelin, Christoph E, Sigel, Eric A, Soutter, Holly H, Troast, Dawn M, Zhang, Ying, Cuozzo, John W, Keefe, Anthony D, Roche, Didier, Rodeschini, Vincent, Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James M, Fedorov, Oleg, Huber, Kilian V. M, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V, Gorjánácz, Mátyás
Published in ACS chemical biology (17.11.2017)
Published in ACS chemical biology (17.11.2017)
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Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl‑1 Inhibitors
Johannes, Jeffrey W., Bates, Stephanie, Beigie, Carl, Belmonte, Matthew A., Breen, John, Cao, Shenggen, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph E., Ferguson, Andrew D., Habeshian, Sevan, Hargreaves, David, Joubran, Camil, Kazmirski, Steven, Keefe, Anthony D., Lamb, Michelle L., Lan, Haiye, Li, Yunxia, Ma, Hao, Mlynarski, Scott, Packer, Martin J., Rawlins, Philip B., Robbins, Daniel W., Shen, Haidong, Sigel, Eric A., Soutter, Holly H., Su, Nancy, Troast, Dawn M., Wang, Haiyun, Wickson, Kate F., Wu, Chengyan, Zhang, Ying, Zhao, Qiuying, Zheng, Xiaolan, Hird, Alexander W.
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Corrigendum: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNAEncoded Chemical Library
Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.
Published in Chembiochem : a European journal of chemical biology (14.12.2017)
Published in Chembiochem : a European journal of chemical biology (14.12.2017)
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Inside Cover: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library (ChemBioChem 9/2017)
Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.
Published in Chembiochem : a European journal of chemical biology (04.05.2017)
Published in Chembiochem : a European journal of chemical biology (04.05.2017)
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Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target
Brown, Dean G., Brown, Giles A., Centrella, Paolo, Certel, Kaan, Cooke, Robert M., Cuozzo, John W., Dekker, Niek, Dumelin, Christoph E., Ferguson, Andrew, Fiez-Vandal, Cédric, Geschwindner, Stefan, Guié, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Schlenker, Oliver, Sigel, Eric A., Snijder, Arjan, Soutter, Holly T., Sundström, Linda, Troast, Dawn M., Wiggin, Giselle, Zhang, Jing, Zhang, Ying, Clark, Matthew A.
Published in SLAS discovery (01.06.2018)
Published in SLAS discovery (01.06.2018)
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Correction to “Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl‑1 Inhibitors”
Johannes, Jeffrey W, Bates, Stephanie, Beigie, Carl, Belmonte, Matthew A, Breen, John, Cao, Shenggen, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Ferguson, Andrew D, Habeshian, Sevan, Hargreaves, David, Joubran, Camil, Kazmirski, Steven, Keefe, Anthony D, Lamb, Michelle L, Lan, Haiye, Li, Yunxia, Ma, Hao, Mlynarski, Scott, Packer, Martin J, Rawlins, Philip B, Robbins, Daniel W, Shen, Haidong, Sigel, Eric A, Soutter, Holly H, Su, Nancy, Troast, Dawn M, Wang, Haiyun, Wickson, Kate F, Wu, Chengyan, Zhang, Ying, Zhao, Qiuying, Zheng, Xiaolan, Hird, Alexander W
Published in ACS medicinal chemistry letters (09.11.2017)
Published in ACS medicinal chemistry letters (09.11.2017)
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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins
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Published in Journal of medicinal chemistry (04.11.2024)
Published in Journal of medicinal chemistry (04.11.2024)
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Abstract 5084: Potent and isoform-selective ATAD2 bromodomain inhibitor with unprecedented chemical structure and mode of action
Fernández-Montalván, Amaury E., Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Holton, Simon J., Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James, Federov, Oleg, Huber, Kilian, Centrella, Paolo, Clark, Matthew A., Dumelin, Christoph E., Sigel, Eric A., Soutter, Holly S., Troast, Dawn M., Zhang, Ying, Cuozzo, John W., Keefe, Anthony D., Roche, Didier, Rodeschini, Vincent, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V., Gorjanacz, Matyas
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Machine learning on DNA-encoded libraries: A new paradigm for hit-finding
McCloskey, Kevin, Sigel, Eric A, Kearnes, Steven, Xue, Ling, Tian, Xia, Moccia, Dennis, Gikunju, Diana, Bazzaz, Sana, Chan, Betty, Clark, Matthew A, Cuozzo, John W, Marie-Aude Guié, Guilinger, John P, Huguet, Christelle, Hupp, Christopher D, Keefe, Anthony D, Mulhern, Christopher J, Zhang, Ying, Riley, Patrick
Published in arXiv.org (31.01.2020)
Published in arXiv.org (31.01.2020)
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A resource to enable chemical biology and drug discovery of WDR Proteins
Arrowsmith, Cheryl H, Ackloo, Suzanne, Li, Fengling, Szewczyk, Magda, Seitova, Almagul, Loppnau, Peter, Zeng, Hong, Ahmad, Shabbir, Beldar, Serap, Bolotokova, Albina, Chau, Irene, Dehghani-Tafti, Saba, Dong, Aiping, Ghiabi, Pegah, Gibson, Elisa, Green, Stuart R, Herasymenko, Oleksandra, Houliston, Scott, Hutchinson, Ashley, Kimani, Serah W, Kutera, Maria, Kwak, Haejin A, Li, Yanjun, Raquel Ac Machado, Perveen, Sumera, Righetto, Germanna L, Shrestha, Suman, Silva, Madhushika, Yadav, Manisha, Yazdi, Aliakbar K, Santhakumar, Vijayaratnam, Edwards, Aled M, Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Brown, Peter J, Halabelian, Levon, Xu, Jin, Feng, Jianwen A, Kearnes, Steven, Thompson, James, Torng, Wen, Gilmer, Justin, Riley, Patrick, Watson, Ian, Arnautova, Yelena A, Baghaie, Aj, Cuozzo, John W, Disch, Jeremy S, Dumas, Antoine, Harms, Nathan, Liu, Jenny, Sigel, Eric A, Goldman, Brian, Kramer, Trevor, Mulhern, Christopher A, Slakman, Belinda L, Underkoffler, Carl, Moritz Von Rechenberg, Centrella, Paolo A, Clark, Matthew A, Marie-Aude Guie, Gullinger, John P, Keefe, Anthony D, Taylor, Rhys D, Zhang, Junyi, Zhang, Ying, Lento, Cristina, Wilson, Derek J, Wolf, Esther, Loup, Joachim, Sintchak, Michael D
Published in bioRxiv (04.03.2024)
Published in bioRxiv (04.03.2024)
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