Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
Wei, Tuo, Cheng, Qiang, Min, Yi-Li, Olson, Eric N, Siegwart, Daniel J
Published in Nature communications (26.06.2020)
Published in Nature communications (26.06.2020)
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ATRP in the design of functional materials for biomedical applications
Siegwart, Daniel J., Oh, Jung Kwon, Matyjaszewski, Krzysztof
Published in Progress in polymer science (01.01.2012)
Published in Progress in polymer science (01.01.2012)
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Dendrimer‐Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I
Cheng, Qiang, Wei, Tuo, Jia, Yuemeng, Farbiak, Lukas, Zhou, Kejin, Zhang, Shuyuan, Wei, Yonglong, Zhu, Hao, Siegwart, Daniel J.
Published in Advanced materials (Weinheim) (01.12.2018)
Published in Advanced materials (Weinheim) (01.12.2018)
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Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA
Miller, Jason B., Zhang, Shuyuan, Kos, Petra, Xiong, Hu, Zhou, Kejin, Perelman, Sofya S., Zhu, Hao, Siegwart, Daniel J.
Published in Angewandte Chemie International Edition (19.01.2017)
Published in Angewandte Chemie International Edition (19.01.2017)
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Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
Chen, Peiwen, Zuo, Hao, Xiong, Hu, Kolar, Matthew J., Chu, Qian, Saghatelian, Alan, Siegwart, Daniel J., Wan, Yihong
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
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Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers
Yan, Yunfeng, Xiong, Hu, Zhang, Xinyi, Cheng, Qiang, Siegwart, Daniel J
Published in Biomacromolecules (11.12.2017)
Published in Biomacromolecules (11.12.2017)
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Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes
Liu, Shuai, Wang, Xu, Yu, Xueliang, Cheng, Qiang, Johnson, Lindsay T, Chatterjee, Sumanta, Zhang, Di, Lee, Sang M, Sun, Yehui, Lin, Ting-Chih, Liu, John L, Siegwart, Daniel J
Published in Journal of the American Chemical Society (22.12.2021)
Published in Journal of the American Chemical Society (22.12.2021)
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High‐Contrast Fluorescence Detection of Metastatic Breast Cancer Including Bone and Liver Micrometastases via Size‐Controlled pH‐Activatable Water‐Soluble Probes
Xiong, Hu, Zuo, Hao, Yan, Yunfeng, Occhialini, Gino, Zhou, Kejin, Wan, Yihong, Siegwart, Daniel J.
Published in Advanced materials (Weinheim) (01.08.2017)
Published in Advanced materials (Weinheim) (01.08.2017)
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The Polyploid State Plays a Tumor-Suppressive Role in the Liver
Zhang, Shuyuan, Zhou, Kejin, Luo, Xin, Li, Lin, Tu, Ho-Chou, Sehgal, Alfica, Nguyen, Liem H., Zhang, Yu, Gopal, Purva, Tarlow, Branden D., Siegwart, Daniel J., Zhu, Hao
Published in Developmental cell (26.02.2018)
Published in Developmental cell (26.02.2018)
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Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model
Zhou, Kejin, Nguyen, Liem H., Miller, Jason B., Yan, Yunfeng, Kos, Petra, Xiong, Hu, Li, Lin, Hao, Jing, Minnig, Jonathan T., Zhu, Hao, Siegwart, Daniel J.
Published in Proceedings of the National Academy of Sciences - PNAS (19.01.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (19.01.2016)
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Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration
Zhang, Shuyuan, Nguyen, Liem H., Zhou, Kejin, Tu, Ho-Chou, Sehgal, Alfica, Nassour, Ibrahim, Li, Lin, Gopal, Purva, Goodman, Joshua, Singal, Amit G., Yopp, Adam, Zhang, Yu, Siegwart, Daniel J., Zhu, Hao
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2018)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2018)
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Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)
Álvarez-Benedicto, Ester, Farbiak, Lukas, Márquez Ramírez, Martha, Wang, Xu, Johnson, Lindsay T, Mian, Osamah, Guerrero, Erick D, Siegwart, Daniel J
Published in Biomaterials science (18.01.2022)
Published in Biomaterials science (18.01.2022)
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Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models
Wei, Tuo, Sun, Yehui, Cheng, Qiang, Chatterjee, Sumanta, Traylor, Zachary, Johnson, Lindsay T, Coquelin, Melissa L, Wang, Jialu, Torres, Michael J, Lian, Xizhen, Wang, Xu, Xiao, Yufen, Hodges, Craig A, Siegwart, Daniel J
Published in Nature communications (11.11.2023)
Published in Nature communications (11.11.2023)
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Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery
Hao, Jing, Kos, Petra, Zhou, Kejin, Miller, Jason B, Xue, Lian, Yan, Yunfeng, Xiong, Hu, Elkassih, Sussana, Siegwart, Daniel J
Published in Journal of the American Chemical Society (29.07.2015)
Published in Journal of the American Chemical Society (29.07.2015)
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