Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma
Sakemura, Reona, Hefazi, Mehrdad, Siegler, Elizabeth L., Cox, Michelle J., Larson, Daniel P., Hansen, Michael J., Roman, Claudia Manriquez, Schick, Kendall J, Can, Ismail, Tapper, Erin E., Horvei, Paulina, Adada, Mohamad M., Bezerra, Evandro D., Fonkoua, Lionel Aurelien Kankeu, Ruff, Michael W., Nevala, Wendy K., Walters, Denise K., Parikh, Sameer A., Lin, Yi, Jelinek, Diane F., Kay, Neil E., Bergsagel, P. Leif, Kenderian, Saad S.
Published in Blood (30.06.2022)
Published in Blood (30.06.2022)
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Journal Article
IL-4 drives exhaustion of CD8+ CART cells
Stewart, Carli M., Siegler, Elizabeth L., Sakemura, R. Leo, Cox, Michelle J., Huynh, Truc, Kimball, Brooke, Mai, Long, Can, Ismail, Manriquez Roman, Claudia, Yun, Kun, Sirpilla, Olivia, Girsch, James H., Ogbodo, Ekene, Mohammed Ismail, Wazim, Gaspar-Maia, Alexandre, Budka, Justin, Kim, Jenny, Scholler, Nathalie, Mattie, Mike, Filosto, Simone, Kenderian, Saad S.
Published in Nature communications (12.09.2024)
Published in Nature communications (12.09.2024)
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Journal Article
In vivo CART cell imaging: Paving the way for success in CART cell therapy
Sakemura, Reona, Can, Ismail, Siegler, Elizabeth L., Kenderian, Saad S.
Published in Molecular therapy. Oncolytics (26.03.2021)
Published in Molecular therapy. Oncolytics (26.03.2021)
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Journal Article
ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation
Rohrs, Jennifer A., Siegler, Elizabeth L., Wang, Pin, Finley, Stacey D.
Published in iScience (24.04.2020)
Published in iScience (24.04.2020)
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Journal Article
Treatment strategies for relapse after CAR T-cell therapy in B cell lymphoma
Negishi, Shuto, Girsch, James H, Siegler, Elizabeth L, Bezerra, Evandro D, Miyao, Kotaro, Sakemura, R Leo
Published in Frontiers in pediatrics (12.01.2024)
Published in Frontiers in pediatrics (12.01.2024)
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Journal Article
CART Cell Toxicities: New Insight into Mechanisms and Management
Zahid, Anas, Siegler, Elizabeth L., Kenderian, Saad S.
Published in Clinical hematology international (01.12.2020)
Published in Clinical hematology international (01.12.2020)
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Journal Article
CAR-T Cell Therapy: the Efficacy and Toxicity Balance
Chohan, Karan L., Siegler, Elizabeth L., Kenderian, Saad S.
Published in Current hematologic malignancy reports (01.04.2023)
Published in Current hematologic malignancy reports (01.04.2023)
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Journal Article
Combination Cancer Therapy Using Chimeric Antigen Receptor-Engineered Natural Killer Cells as Drug Carriers
Siegler, Elizabeth L., Kim, Yu Jeong, Chen, Xianhui, Siriwon, Natnaree, Mac, John, Rohrs, Jennifer A., Bryson, Paul D., Wang, Pin
Published in Molecular therapy (06.12.2017)
Published in Molecular therapy (06.12.2017)
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Journal Article
Evaluating CAR-T Cell Therapy in a Hypoxic 3D Tumor Model
Ando, Yuta, Siegler, Elizabeth L, Ta, Hoang P, Cinay, Gunce E, Zhou, Hao, Gorrell, Kimberly A, Au, Hannah, Jarvis, Bethany M, Wang, Pin, Shen, Keyue
Published in Advanced healthcare materials (01.03.2019)
Published in Advanced healthcare materials (01.03.2019)
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Journal Article
Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia
Cox, Michelle J., Lucien, Fabrice, Sakemura, Reona, Boysen, Justin C., Kim, Yohan, Horvei, Paulina, Manriquez Roman, Claudia, Hansen, Michael J., Tapper, Erin E., Siegler, Elizabeth L., Forsman, Cynthia, Crotts, Sydney B., Schick, Kendall J., Hefazi, Mehrdad, Ruff, Michael W., Can, Ismail, Adada, Mohamad, Bezerra, Evandro, Kankeu Fonkoua, Lionel Aurelien, Nevala, Wendy K., Braggio, Esteban, Ding, Wei, Parikh, Sameer A., Kay, Neil E., Kenderian, Saad S.
Published in Molecular therapy (07.04.2021)
Published in Molecular therapy (07.04.2021)
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Journal Article
CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS
Sakemura, R Leo, Manriquez Roman, Claudia, Horvei, Paulina, Siegler, Elizabeth L, Girsch, James H, Sirpilla, Olivia L, Stewart, Carli M, Yun, Kun, Can, Ismail, Ogbodo, Ekene J, Adada, Mohamad M, Bezerra, Evandro D, Kankeu Fonkoua, Lionel Aurelien, Hefazi, Mehrdad, Ruff, Michael W, Kimball, Brooke L, Mai, Long K, Huynh, Truc N, Nevala, Wendy K, Ilieva, Kristina, Augsberger, Christian, Patra-Kneuer, Maria, Schanzer, Jürgen, Endell, Jan, Heitmüller, Christina, Steidl, Stefan, Parikh, Sameer A, Ding, Wei, Kay, Neil E, Nowakowski, Grzegorz S, Kenderian, Saad S
Published in Blood (18.01.2024)
Published in Blood (18.01.2024)
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Journal Article
GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity
Cox, Michelle J, Manriquez Roman, Claudia, Tapper, Erin E, Siegler, Elizabeth L, Chappell, Dale, Durrant, Cameron, Ahmed, Omar, Sinha, Sutapa, Mwangi, Raphael, Scott, Nancy S, Hefazi, Mehrdad, Schick, Kendall J, Horvei, Paulina, Ruff, Michael W, Can, Ismail, Adada, Mohamad, Bezerra, Evandro, Kankeu Fonkoua, Lionel Aurelien, Parikh, Sameer A, Kay, Neil E, Sakemura, Reona, Kenderian, Saad S
Published in Leukemia (01.06.2022)
Published in Leukemia (01.06.2022)
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Journal Article