Search Results - "Siegfried Goldmann" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly

Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly

by Wu, Guoyi, Liu, Bo, Zhang, Yingjun, Li, Jing, Arzumanyan, Alla, Clayton, Marcia M, Schinazi, Raymond F, Wang, Zhaohe, Goldmann, Siegfried, Ren, Qingyun, Zhang, Faxhou, Feitelson, Mark A
Published in Antimicrobial Agents and Chemotherapy (01.11.2013)

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Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)

Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)

by Ren, Qingyun, Liu, Xinchang, Luo, Zhonghua, Li, Jing, Wang, Chaolei, Goldmann, Siegfried, Zhang, Jiancun, Zhang, Yingjun
Published in Bioorganic & medicinal chemistry (01.02.2017)

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Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids

Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids

by Deres, Karl, Schröder, Claus H., Paessens, Arnold, Goldmann, Siegfried, Hacker, Hans Jörg, Weber, Olaf, Krämer, Thomas, Niewöhner, Ulrich, Pleiss, Ulrich, Stoltefuss, Jürgen, Graef, Erwin, Koletzki, Diana, Ralf N. A. Masantschek, Reimann, Anja, Jaeger, Rainer, Groβ, Rainer, Beckermann, Bernhard, Schlemmer, Karl-Heinz, Haebich, Dieter, Rübsamen-Waigmann, Helga
Published in Science (American Association for the Advancement of Science) (07.02.2003)

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Further Optimization of a Scalable Biocatalytic Route to (3R)‑N‑Boc-3-aminoazepane with Immobilized ω‑Transaminase

Further Optimization of a Scalable Biocatalytic Route to (3R)‑N‑Boc-3-aminoazepane with Immobilized ω‑Transaminase

by Feng, Yahui, Wang, Zhongqing, Luo, Zhonghua, Chen, Minghong, He, Fang, Liu, Bin, Goldmann, Siegfried, Zhang, Lei
Published in Organic process research & development (15.03.2019)

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Inhibition of murine cytomegalovirus and human cytomegalovirus by a novel non-nucleosidic compound in vivo

Inhibition of murine cytomegalovirus and human cytomegalovirus by a novel non-nucleosidic compound in vivo

by Weber, Olaf, Bender, Wolfgang, Eckenberg, Peter, Goldmann, Siegfried, Haerter, Michael, Hallenberger, Sabine, Henninger, Kerstin, Reefschläger, Jürgen, Trappe, Jörg, Witt-Laido, Astrid, Ruebsamen-Waigmann, Helga
Published in Antiviral research (01.03.2001)

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3‑((R)‑4-(((R)‑6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4

3‑((R)‑4-(((R)‑6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4

by Ren, Qingyun, Liu, Xinchang, Yan, Guanghua, Nie, Biao, Zou, Zhifu, Li, Jing, Chen, Yunfu, Wei, Yu, Huang, Jianzhou, Luo, Zhonghua, Gu, Baohua, Goldmann, Siegfried, Zhang, Jiancun, Zhang, Yingjun
Published in Journal of medicinal chemistry (08.02.2018)

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Development of an Efficient and Scalable Biocatalytic Route to (3R)‑3-Aminoazepane: A Pharmaceutically Important Intermediate

Development of an Efficient and Scalable Biocatalytic Route to (3R)‑3-Aminoazepane: A Pharmaceutically Important Intermediate

by Feng, Yahui, Luo, Zhonghua, Sun, Guodong, Chen, Minghong, Lai, Jinqiang, Lin, Wei, Goldmann, Siegfried, Zhang, Lei, Wang, Zhongqing
Published in Organic process research & development (21.04.2017)

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Influences on viral replication and sensitivity to GLS4, a HAP compound, of naturally occurring T109/V124 mutations in hepatitis B virus core protein

Influences on viral replication and sensitivity to GLS4, a HAP compound, of naturally occurring T109/V124 mutations in hepatitis B virus core protein

by Wang, Jianghua, Zhang, Haiying, Zhang, Yingjun, Jiang, Dong, Li, Jing, Goldmann, Siegfried, Ren, Qingyun, Fei, Ran, Wang, Xueyan, Wei, Lai
Published in Journal of medical virology (01.10.2017)

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Identification, Characterization, Synthesis, and Strategy for Minimization of Potential Impurities Observed in the Synthesis of Solithromycin

Identification, Characterization, Synthesis, and Strategy for Minimization of Potential Impurities Observed in the Synthesis of Solithromycin

by Zhong, Zhihong, Du, Chong, Luo, Zhonghua, Song, Shuaihua, Liao, Gaohong, Yao, Jia, Goldmann, Siegfried, Wang, Zhongqing
Published in Organic process research & development (15.09.2017)

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IK Ca-channel blockers. Part 2: Discovery of cyclohexadienes

IK Ca-channel blockers. Part 2: Discovery of cyclohexadienes

by Urbahns, Klaus, Goldmann, Siegfried, Krüger, Jochen, Horváth, Ervin, Schuhmacher, Joachim, Grosser, Rolf, Hinz, Volker, Mauler, Frank
Published in Bioorganic & medicinal chemistry letters (17.01.2005)

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Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action

Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action

by Reefschlaeger, Juergen, Bender, Wolfgang, Hallenberger, Sabine, Weber, Olaf, Eckenberg, Peter, Goldmann, Siegfried, Haerter, Michael, Buerger, Iris, Trappe, Joerg, Herrington, Janet A., Haebich, Dieter, Ruebsamen-Waigmann, Helga
Published in Journal of antimicrobial chemotherapy (01.12.2001)

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BROMO-PHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES

BROMO-PHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES

by LIU YISONG, LI JING, SIEGFRIED GOLDMANN
Year of Publication 12.04.2010

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Patent

Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: inhibition and inactivation of glycogen phosphorylase by an activated metabolite

Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: inhibition and inactivation of glycogen phosphorylase by an activated metabolite

by BERGANS, N, STALMANS, W, GOLDMANN, S, VANSTAPEL, F
Published in Diabetes (New York, N.Y.) (01.09.2000)

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DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS

DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS

by LIU, Xinchang, ZHANG, Yingjun, REN, Qingyun, GOLDMANN, Siegfried
Year of Publication 24.03.2023

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Patent

IKCa-channel blockers. Part 2: Discovery of cyclohexadienes

IKCa-channel blockers. Part 2: Discovery of cyclohexadienes

by URBAHNS, Klaus, GOLDMANN, Siegfried, KRÜGER, Jochen, HORVATH, Ervin, SCHUHMACHER, Joachim, GROSSER, Rolf, HINZ, Volker, MAULER, Frank
Published in Bioorganic & medicinal chemistry letters (17.01.2005)

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Journal Article

Dihydropyrimidine compounds and uses thereof in medicine

Dihydropyrimidine compounds and uses thereof in medicine

by LIU, Xinchang, REN, Qingyun, ZHANG, Yingjun, YAN, Guanghua, GOLDMANN, Siegfried
Year of Publication 15.12.2022

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Patent

DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE

DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE

by LIU, Xinchang, REN, Qingyun, ZHANG, Yingjun, YAN, Guanghua, GOLDMANN, Siegfried
Year of Publication 30.11.2022

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Patent

Dihydropyrimidine compounds and uses thereof in medicine

Dihydropyrimidine compounds and uses thereof in medicine

by Ren, Qingyun, Liu, Xinchang, Yan, Guanghua, Goldmann, Siegfried, Zhang, Yingjun
Year of Publication 01.03.2022

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Patent

Dihydropyrimidine compounds and uses thereof in medicine

Dihydropyrimidine compounds and uses thereof in medicine

by HUANG, Jianzhou, LIU, Xinchang, REN, Qingyun, ZHANG, Yingjun, GOLDMANN, Siegfried
Year of Publication 27.01.2022

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Patent

Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarboxylate

Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarboxylate

by OIKONOMAKOS, NIKOS G., TSITSANOU, KATERINA E., ZOGRAPHOS, SPYROS E., SKAMNAKI, VICKY T., GOLDMANN, SIEGFRIED, BISCHOFF, HILMAR
Published in Protein science (01.10.1999)

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